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Jinhee Choi '10

Dexamethasone vs. Ibupofen for acute sore throat pain

Background: Studies in adults have shown the benefit of corticosteroid or nonsteroidal anti-inflammatory drugs (NSAID) on the reduction of severity and duration of acute pharyngitis pain. However, despite these clinical insights, there has been no comparative study between corticosteroid medications and NSAIDs.

Methods: A prospective, randomized, double blind, 2-arm controlled study will be employed to evaluate the difference of 3 daily doses of dexamethasone versus 600 mg of ibuprofen three times a day in the treatment of 18-40 year old patients with acute pharyngitis. The primary endpoint will be the reduction in severity of pain. Scheduled pain assessments will be performed at day 2 following drug onset, at 1 week, and 2 weeks following.

Significance: The results of this study may influence the clinical use of corticosteroids or NSAIDs for the treatment of pharyngitis pain. For instance, the use of dexamethasone may be unnecessary if NSAIDs have a similar clinical effect on pain reduction.

 

 


 

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Otolaryngology Surgery University of Wisconsin Department of Surgery
First published: 07/15/02 Last updated: 11/24/09 webmaster@surgery.wisc.edu
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