Gregory Sewall ‘06

Sewall GK, Robertson KM, Connor NP, Heisey DM, Hartig GK. Effect of topical Mitomycin-C on skin wound contraction. Archives of Facial Plastic Surg 2003;5(1):59-62

Objective : To evaluate the effect of different dosing regimens of Mitomycin-C on skin wound contraction.

Methods: Full thickness skin wounds were created in 5 groups of hairless mice, which represented different dosing regimens or a sterile water control: (A) control, (B) Mitomycin-C (0.5 mg/mL) applied immediately following creation of the lesion (day 1), (C) Mitomycin-C (1.0 mg/mL) applied on day 1, (D) Mitomycin-C (0.5 mg/mL) applied on days 1 and 3, and (E) Mitomycin-C (1.0 mg/mL) applied on days 1 and 3. Measurements of wound surface area were made immediately following drug application (day 1), and thereafter every 3 to 5 days until day 29 using computer-assisted image analysis.

Results: All dosing regimens of Mitomycin-C application resulted in an initially exponential rate of wound contraction that was significantly slower than the sterile water control, with a significantly larger wound surface area on day 29. Wound area in the control group contracted approximately 9 times more rapidly than the treatments. No difference was observed among the different dosing regimens.

Conclusions: Application of Mitomycin-C, at the lowest dose and frequency of application used in this study resulted in improved outcomes with regard to contraction of full-thickness skin wounds.

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First published: 07/15/02 Last updated: 11/24/09 webmaster@surgery.wisc.edu
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