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The Thyroid Gland

Recent UW Publications

  1. Chen H, Nicol TL, Udelsman R. Follicular lesions of the thyroid. Does frozen section evaluation alter operative management? Ann Surg. 1995; 222:101-106.
  2. Chen H, Carson-Walter EB, Baylin SB, Nelkin BD, Ball DW. Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1. Surgery 1996; 120:168-173.
  3. Chen H, Zeiger MA, Clark DP, Westra WH, Udelsman R. Papillary carcinoma of the thyroid: can operative management be based solely on fine needle aspiration? J Am Coll Surg. 1997; 184:605-610.
  4. Saji M, Westra WH, Chen H, Umbricht C, Tuttle RM, Box MF, Udelsman R, Sukumar S, Zeiger MA. Telomerase activity in the differential diagnosis of papillary carcinoma of the thyroid. Surgery. 1997; 122:1137-1140.
  5. Chen H, Udelsman R. Papillary thyroid carcinoma: justification for total thyroidectomy and the management of lymph node metastases. Surg Oncol Clin N Am. 1998; 7:645-663.
  6. Chen H, Nicol TL, Zeiger MA, Dooley WC, Ladenson PW, Cooper DS, Ringel M, Parkerson S, Allo M, Udelsman R. Hurthle cell neoplasms of the thyroid: are there factors predictive of malignancy? Ann Surg. 1998; 227:542-546.
  7. Chen H, Roberts JR, Ball DW, Eisele DW, Baylin SB, Udelsman R, Bulkley GB. Effective long-term palliation of symptomatic, incurable metastatic medullary thyroid cancer by operative resection. Ann Surg. 1998; 227:887-895.
  8. Chen H, Nicol TL, Udelsman R. Clinically significant metastatic disease to the thyroid gland. World J Surg. 1999; 23:177-181.
  9. Cha C, Chen H, Westra WH, Udelsman R. Primary Thyroid Lymphoma: Can the Diagnosis Be Made Solely by Fine-Needle Aspiration? Annals of Surgical Oncology 2002; 9:298-302.
  10. Sippel RS, Gauger PG, Angelos P, Thompson NW, Mack E, Chen H. Palliative Thyroidectomy for Malignant Lymphoma of the Thyroid. Annals of Surgical Oncology 2002; 9:907-911.
  11. Chen H, Dudley NE, Westra WH, Sadler GP, Udelsman R. The Utilization of Fine-Needle Aspiration in Patients Undergoing Thyroidectomy at Two Academic Centers Across the Atlantic. World J Surg 2003; 27:208-211.
  12. Sippel RS, Carpenter JE, Kunnimalaiyaan M, Chen H. The Role of Human Achaete-Scute Homolog-1 in Medullary Thyroid Cancer Cells. Surgery. 2003; 134:866-73.
  13. Callcut R, Selvaggi SM, Mack E, Ozgul O, Warner TF, Chen H. The Utility of Frozen Section Evaluation for Follicular Thyroid Lesions. Annals of Surgical Oncology 2004; 11:94-98.
  14. Chen H, Udelsman R. Hurthle cell adenoma and carcinoma. In: Clark OH, Duh QY, eds. Textbook of Endocrine Surgery. Philadelphia, PA: W.B. Saunders Company; 1997.
  15. Chen H, Nicol TL, Rosenthal DL, Udelsman R. The role of fine needle aspiration in the evaluation of thyroid nodules. In: Norton JA, ed. Problems in General Surgery: Surgery of the Thyroid Gland. New York, NY: Lippincott-Raven Publishers; 1997.
  16. Udelsman R, Chen H. The current management of thyroid cancer. In: Cameron JL, ed. Advances in Surgery. St. Louis, Mo: Mosby, Inc.; 1999; No. 33.
  17. Chen H, Udelsman R. Follicular, Hurthle Cell, and Anaplastic Thyroid Cancer. In: Bland KI, ed. The Practice of General Surgery. Philadelphia, PA: W.B. Saunders Co., 2001.
  18. Chen H, Udelsman R. Hurthle cell adenoma and carcinoma. In: Clark OH, Duh QY, eds. Textbook of Endocrine Surgery 2nd ed. Philadelphia, PA: W.B. Saunders Company, 2005; 123-128.
  19. Sippel RS, Chen H. Multiple Endocrine Neoplasia. In: Goldin SB, Zervos EE, eds. Pocket Surgical Oncology. Philadelphia, PA: PocketMedicine.com, Inc. 2003.
  20. Sippel RS, Chen H. Reoperative Endocrine Surgery. In: Callery M, ed. Handbook of Reoperative General Surgery. Maiden, MA: Blackwell Publishing, Inc., 2006; 135-150.
  21. Sippel RS, Chen H. Thyroid and Parathyroid Disorders. In: Makary M, ed. General Surgery Review. New York, NY: Springer, 2004; 9-22.
  22. Sippel RD, Chen H. Thyroid Lymphoma and other Metastatic Lesions. In: Oertli D, Udelsman R, eds. Surgery of the Thyroid and Parathyroid Glands. Heidelberg, Germany: Springer-Verlag. 2007; 171-177.
  23. Chen H, Kunnimalaiyaan M, Van Gompel JJ. Medullary Thyroid Cancer: the functions of raf-1 and human achaete-scute homolog-1. Thyroid. 2005; 15(6):515-525.
  24. Greenblatt DY, Woltman T, Harter J, Starling J, Mack E, Chen H. Fine-Needle Aspiration Optimizes Surgical Management in Patients with Thryoid Cancer. Annals of Surgical Oncology. 2006; 31:9-12.
  25. Chen H. Fine Needle Aspiration of the Thyroid. In: Moley JF, ed. Surgery of the Thyroid Gland. American College of Surgeons postgraduate course syllabus, 2005; 21-23.
  26. Schussler-Fiorenza C, Bruns C, Chen H. The Surgical Management of Graves' Disease. Journal of Surgical Research. 2006; 133:207-214.
  27. Cheema Y, Olson S, Elson D, Chen H. What is the Biology and Optimal Treatment for Papillary Microcarcinoma of the Thyroid. Journal of Surgical Research. 2006; 134:160-162.
  28. Sippel RS, Ozgul O, Hartig GK, Mack E, Chen H. The Risk and Consequences of Incidental Parathyroidectomy during Thyroid Resection. ANZ Journal of Surgery. 2007; 77:33-36.
  29. Cheema Y, Repplinger D, Elson D, Chen H. Is Tumor Size the Best Predictor of Outcome for Papillary Thyroid Cancer. Annals of Surgical Oncology. 2006; 13:1524-1528.
  30. Greenblatt DY, Chen H. Palliation of Advanced Thyroid Malignancies. Surgical Oncology. 2007; 16:237-247.
  31. Greenblatt DY, Elson D, Mack E, Chen H. Initial Lymph Node Dissection Increases Cure Rates in Patients with Medullary Thyroid Cancer. Asian Journal of Surgery. 2007; 30:108-112.
  32. Olson S, Cheema Y, Harter J, Starling J, Chen H. Does Frozen Section Alter Surgical Management of Multinodular Thyroid Disease? Journal of Surgical Research. 2006; 136:179-181.
  33. Chen H. Voice Changes after Thyroid Surgery: How Often Do They Occur and Can They Be Prevented? Contemporary Surgery. 2006; 62:410-413.
  34. Sippel RS, Chen H. Thyroid and Parathyroid Disorders. In: Makary M, ed. General Surgery Review, 2nd ed.. Washington DC: Lander-Drysfale. 2008; 165-180.
  35. Kunnimalaiyaan M, Ndiaye M, Chen H. Apoptosis mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. Surgery. 2006; 140:1009-1015.
  36. Kunnimalayaan M, Vaccaro AM, Ndiaye MA, Chen H. Overexpression of the Notch1 Intracellular Domain (NICD) inhibs cellular proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. Journal of Biological Chemistry. 2006; 281:39819-39830.
  37. Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H. Inactivation of glycogen synthase kinase-3, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cell. Molecular Cancer Therapeutics. 2007; 6:1151-1158.
  38. Kunnimalaiyaan M, Haymart MR. Chen H. Tumor Suppressor Role of Notch1 and Raf-1 Signaling in Medullary Thyroid Cancer Cells. Translational Oncogenomics. 2007; 2:43-47.
  39. Olson S. Starling JR, Chen H. Symptomatic Benign Multinodular Goiter: Unilateral or Bilateral Thyroidectomy? Surgery. 2007; 142:458-462.
  40. Repplinger D, Bargren A, Zhang Y, Adler JT, Haymart M, Chen H. Is Hashimoto's thyroiditis a risk factor for papillary thyroid cancer? Journal of Surgical Research. 2008; 150: 49-52.
  41. Chen H. Pre-operative management of patients with Graves' disease. Surgery.2008; 143:292-293.
  42. Haymart MR, Greenblatt DY, Elson DF, Chen H. The Role of Intraoperative Frozen Section if Suspicious for Papillary Thyroid Cancer. Thyroid. 2008; 18:419-423.
  43. Haymart MR, Repplinger DJ, Leverson GE, Elson DF, Sippel RS, Jaume JC, Chen H. Higher Serum TSH Level in Thyroid Nodule Patients is Associated with Greater Risks of Differentiated Thyroid Cancer and Advanced Tumor Stage. Journal of Clinical Endocrinology and Metabolism. 2008; 93:809-814
  44. Greenblatt DY, Cayo M, Adler JT, Ning L, Haymart M, Kunnimalaiyaan M, Chen H. Valproic Acid Activates Notch1 Signaling and Induces Apoptosis in Medullary Thyroid Cancer Cells. Ann Surg. 2008; 247:1036-1040.
  45. Sippel RS, Kunnimalaiyaan M, Chen H. Current Management of Medullary Thyroid Cancer.  The Oncologist. 2008; 13:539-547.
  46. Ning L, Jaskula-Sztul R, Kunnimalaiyaan M, Chen H. Suberoyl bishydroxamic acid activates Notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma.  Annals of Surgical Oncology. 2008; 15:2600-2605.
  47. Ning L, Kunnimalaiyaan M, Chen H. Regulation of cell-cell contact molecules and the metastatic phenotype of medullary thyroid carcinoma by the Raf-1/MEK/ERK pathway. Surgery. 2008; 144:920-925.
  48. Pinchot SN, Chen H, Sippel RS. Incisions and Exposure of the Neck for Thyroidectomy and Parathyroidectomy. Operative Techniques in General Surgery. 2008; 10:63-76.
  49. Sippel RS, and Chen H. Medullary Thyroid Cancer. In: Loh, and Inabnet, eds. Endocrine Surgery. (in press)
  50. Pinchot SN, Sippel RS, Chen H. Multi-targeted approach in the treatment of thyroid cancer. Therapeutics and Clinical Risk Management. 2008; 4:1-13.
  51. Musunuru S, Schaefer S, Chen H.  The Use of the Ligasure for Hemostasis During Thyroid Lobectomy. Am. J. Surg. 2008; 195:382-385.
  52. Ning L, Greenblatt DY, Kunnimalaiyaan M, Chen H. Suberoyl Bis-Hydroxamic Acid Activates Notch1 Signaling and Induces Apoptosis in Medullary Thyroid Carcinoma Cells. The Oncologist 2008; 13:98-104.
  53. Zhang Y, Greenblatt DY, Repplinger DJ, Bargren A, Adler JT, Sippel RS, Chen H. Older Age and Larger Tumor Size Predict Malignancy in Hürthle Cell Neoplasms of the Thyroid. Annals of Surgical Oncology. 2008; 15:2842-2846.
  54. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitors and lithium chloride. Journal of Surgical Research (in press).
  55. Adler JT, Chen H. Preserving function and quality of life after thyroid and parathyroid surgery. Lancet Oncology. 2008; 9:1069-1075.
  56. Pitt SC, Sippel RS, Chen H. Contralateral papillary thyroid cancer: Does size matter? Am. J. Surg. 2009; 197:342-347.
  57. Greenblatt DY, Sippel RS, Leverson G, Frydman J, Schaefer S, Chen H.  Thyroid Resection Improves Perception of Swallowing Function in Patients with Thyroid Disease. World Journal of Surgery. 2009; 33:255-260.
  58. Haymart MR, Glinberg SL, Liu JL, Sippel RS, Jaume JC, Chen H. Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extension. Clinical Endocrinology. 2009; 71:434-439.
  59. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitors and lithium chloride. Journal of Surgical Research (in press).
  60. Pitt SC, Chen H. The phosphatidylinositol 3-kinase/akt signaling pathway in medullary thyroid cancer. Surgery 2008; 144:721-724.
  61. Chen H. Laryngeal morbidity following thyroidectomy: is it always the surgeon-Invited Critique. Archives of Surgery. 2009; 144:153.
  62. Xiao X, Ning L, Chen H. Notch1 Mediates Growth Suppression of Papillary and Follicular Thyroid Cancer Cells by HDAC Inhibitors. Molecular Cancer Therapeutics. 2009; 8: 350-356.
  63. Pinchot SN, Al-Wagih H, Schaefer S, Sippel RS, Chen H. Accuracy of fine needle aspiration biopsy for predicting neoplasm or carcinoma in thyroid nodules> 4cm. Archives of Surgery. 2009; 914-920.
  64. Adler JT, Cook M, Luo Y, Pitt SC, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of GSK-3ß. Molecular Cancer Therapeutics. 2009; 8:914-920.
  65. Pinchot SN, Sippel RS, Chen H. Multi-targeted approach in the treatment of thyroid cancer. Therapeutics and Clinical Risk Management. 2008; 4:1-13.
  66. Bargren AE Meyer-Rochow GY, Delbridge LW, Sidhu SB, Chen H. Outcomes of surgically managed pediatric thyroid cancer. Journal of Surgical Research. 2009; 156:70-73.
  67. Stoll SJ, Pitt SC, Liu J, Schaefer S, Sippel RS, Chen H. Thyroid hormone replacement after thyroid lobectomy. Surgery. 2009; 146:554-558.
  68. Stoll SJ, Pitt SC, Chen H. Follicular Thyroid Cancer Growth Inhibition by Proteosome Inhibitor MG132. Journal of Surgical Research. 2009; 156:39-44.
  69. Haymart MR, Cayo MA, Chen H. Papillary thyroid microcarcinomas: Big decisions for a small tumor. Annals of Surgical Oncology (in press).
  70. Cook MR, Luo J, Ndiaye M, Chen H, Kunnimalaiyaan M. Xanthohumol Inhibits the Neuroendocrine Transcription Factor Achaete-Scute Complex-Like 1, Suppresses Proliferation and Induces Phosphorylated ERK1/2 in Medullary Thyroid Cancer. Am. J. Surg. (in press).
  71. Schiro AJ, Pinchot SN, Chen H, Sippel RS. Clinical Efficacy of Fine-Needle Aspiration Biopsy of Thyroid Nodules in Males. Journal of Surgical Research (in press).

 

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