Skip repetitive links and go to content
University of Wisconsin - Madison -- Chen Lab
Introduction
Lab Staff
Active Grants
Publications
Library
Journals
Honors and Awards
Contact Information
Additional Links of Interest
General Surgery Home

Publications

  1. Borges MW, Linnoila RI, van de Velde HJ, Chen H, Nelkin BD, Mabry M, Baylin SB, Ball DW. An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature. 1997; 386:852-855.
  2. Chen H, Boyle TJ, Malim M, Cullen BR, Lyerly HK. Derivation of a biologically contained replication system for human immunodeficiency virus type 1. Proc Natl Acad Sci USA. 1992; 89: 7678-7682.
  3. Chen H, Carson-Walter EB, Baylin SB, Nelkin BD, Ball DW. Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1. Surgery 1996; 120:168-173
  4. Chen H, Thiagalingam A, Chopra H, Borges MW, Feder JN, Nelkin BD, Baylin SB, Ball DW. Conservation of the lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc Natl Acad Sci USA. 1997; 94:5355-5360.
  5. Chen H, Udelsman R, Zeiger MA, Ball DW. Human achaete-scute homolog-1 is highly expressed in a subset of neuroendocrine tumors. Oncol Rep. 1997; 4:775-778.
  6. Chen H, Biel MA , Borges MW, Thiagalingam A, Nelkin BD, Baylin SB, Ball DW. Tissue-specific expression of human achaete-scute homolog-1 in neuroendocrine tumors: transcriptional regulation by dual inhibitory regions. Cell Growth Differ. 1997; 8:677-686.
  7. Mansour JC, Chen H. Pancreatic Neuroendocrine Tumors. Journal of Surgical Research 2004; 120: 139-161.
  8. Musunuru S, Carpenter JE, Sippel RS, Kunnimalaiyaan M, Chen H. A Mouse Model of Carcinoid Syndrome and Heart Disease. Journal of Surgical Research. 2005; 126:102-105.
  9. Schneeberger B, Sippel R, Chen H. Activation of the Ras/Raf-1 Pathway in Medullary Thyroid Cancer Cells Induces a Biochemical Differentiation. Surg Forum 2001; 52: 270-271.
  10. Sippel R, Schneeberger B, Chen H. Activation of the Ras/Raf-1 Signal Transduction Pathway Inhibits Growth of Gastrointestinal (GI) Carcinoid Tumor Cells. Surg Forum 2001; 52: 209-210.
  11. Sippel RS, Chen H. Activation of the RAS/RAF-1 Signal transduction pathway in carcinoid tumor cells results in morphologic transdifferentiation. Surgery. 2002; 132:1035-1039.
  12. Sippel RS, Carpenter JE, Kunnimalaiyaan M, Lagerholm S, Chen H. Raf-1 Activation Suppresses Neuroendocrine Marker and Hormone Levels in Human Gastrointestinal Carcinoid Cells. American Journal of Physiology-GI and Liver 2003; 285: G245-G254.
  13. Sippel RS, Carpenter JE, Kunnimalaiyaan M, Chen H. The Role of Human Achaete-Scute Homolog-1 in Medullary Thyroid Cancer Cells. Surgery. 2003; 134: 866-73.
  14. Van Gompel JJ, Chen H. Insulin-like Growth Factor-1 Signaling in Human Gastointestinal Carcinoid Tumor Cells. Surgery. 2004; 136:1297-302.
  15. Van Gompel JJ, Sippel RS, Warner TF, Chen H. Gastrointestinal Carcinoid Tumors: Factors that Predict Outcome. World Journal of Surgery; 28:387-392
  16. Kunnimalaiyaan M, Yan S, Wong F, Zhang Y, Chen H. Hairy Enhancer-of-Split (HES-1), a Notch1 Effector, Inhibits the Growth of Carcinoid Tumor Cells. Surgery. 2005; 138:1137-1142.
  17. Van Gompel JJ, Kunnimalaiyaan M, Holen K, Chen H. ZM336372, a Raf-1 Activator, Suppresses Growth and Neuroendocrine Hormone Levels in Carcinoid Tumor Cells. Molecular Cancer Therapeutics. 2005;4:910-917.
  18. Nakakura EK, Sriuranpong VR, Kunnimalaiyaan M, Hsiao EC, Schuebel KE, Borges MW, Jin N, Collins BJ, Nelkin BD, Chen H*, Ball DW* (co-senior authors*). Regulation of Neuroendocrine Differentiation in Gastrointestinal Carcinoid Tumor Cells by Notch Signaling. Journal of Clinical Endocrinology and Metabolism. 2005; 90:4350-56.
  19. Chen H, Kunnimalaiyaan M, Van Gompel JJ. Medullary Thyroid Cancer: the functions of raf-1 and human achaete-scute homolog-1. Thyroid 2005; 15(6): 515-525.
  20. Kunnimalaiyaan M, Traeger K, Chen H. Conservation of the Notch1 Signaling Pathway in Gastrointestinal Carcinoid Cells. American Journal of Physiology-GI and Liver. 289: G636-642.
  21. Lal A, Chen H. Treatment of Advanced Carcinoid Tumors. Current Opinion in Oncology. 2006; 18:9-15.
  22. Kunnimalaiyaan, M, Chen H. Raf-1 pathway: A molecular target for treatment of select neuroendocrine tumors? Anti-cancer Drugs. 2006; 31:9-12.
  23. Chen H. SSAT/AGA/ASGE State of the Art Conference on Pancreatic Neuroendocrine Tumors: Consensus Statement. J Gastrointest Surg. 2006; 10:321-323.
  24. Musunuru S, Chen H, Rajpal S, Stephani N, McDermott J, Holen K, Rikkers LF, Weber SM. Metastatic Neuroendocrine Hepatic Tumors: Resection Improves Survival. Archives of Surgery. 2006; 141:1000-1004.
  25. Sippel RS, Chen H. Carcinoid Tumors. Surgical Oncology Clinics of North America. 2006; 15:463-478.
  26. Kappes A, Vaccaro A, Kunnimalaiyaan M, Chen H. ZM336372, a Raf-1 Activator, Inhibits Growth of Pheochromocytoma Cells. Journal of Surgical Research. 2006; 133:42-45.
  27. Vaccaro A, Chen H, Kummimalaiyann M. In vivo Activation of Raf-1 Inhibits Tumor Growth and Development in a Xenograft Model of Human Medullary Thyroid Cancer. Anti-Cancer Drugs. 2006; 17:849-853.
  28. Chen H. Management of Pancreatic Islet Cell Tumors Excluding Gastrinoma. In: Cameron JL, ed. Current Surgical Therapy, 9th ed. St. Louis, MO: Elsevier. 2008; 535-539.
  29. Zhao Y, Shen S, Guo J, Chen H, Greenblatt D, Kleeff J, Liao Q, Chen G, Friess H, Leung P. Mitogen-Activated Protein Kinases and Chemoresistance in Pancreatic Cancer Cells. Journal of Surgical Research. (2006; 136:187-191).
  30. Greenblatt DY, Chen H. Imaging and Staging of Gastrointestinal Neuroendocrine Tumors. In: Jankowski, Sampliner, Kerr, Fong, eds. Gastrointestinal Oncology Multidisciplinary Team Approach. (in press).
  31. Kunnimalaiyaan M, Ndiaye M, Chen H. Apoptosis mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. Surgery. 2006; 140:1009-15.
  32. Kappes A, Vaccaro A, Kunnimalaiyaan M, Chen H. Lithium ions: A novel treatment for pheochromocytomas and paragangliomas. Surgery. 2007; 141: 161-165.
  33. Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H. Overexpression of the Notch1 Intracellular Domain (NICD) inhibits cellular proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. Journal of Biological Chemistry. 2006; 281:39819-39830.
  34. Platta CS, Greenblatt DY, Kunnimalaiyaan M, Chen H. The HDAC Inhibitor Trichostatin A Inhibits Growth of Small Cell Lung Cancer Cells. Journal of Surgical Research. 2007; 142:219-226.
  35. Kunnimalaiyaan M, Chen H. Tumor suppressor role of Notch1 signaling in neuroendocrine tumors. The Oncologist. 2007; 12: 535-542.
  36. Greenblatt DY, Kunnimalaiyaan M, Chen H. Raf-1 Activation in Gastrointestinal Carcinoid Cells Reduces Tumor Cell Adhesion. Am. J. Surg. 2007; 193: 331-335.
  37. Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H. Inactivation of glycogen synthase kinase-3, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cell. Molecular Cancer Therapeutics 2007; 6: 1151-1158.
  38. Cayo M, Greenblatt DY, Kunnimalaiyaan M, Chen H. The Raf-1 Gene. Atlas Genet Cytogenet Oncol Haematol. March 2007.
  39. Kunnimalaiyaan M, Haymart MR. Chen H. Tumor Suppressor Role of Notch1 and Raf-1 Signaling in Medullary Thyroid Cancer Cells. Translational Oncogenomics. 2007; 2:43-47.
  40. Greenblatt DY, Vaccaro AM, Jaskula-Sztul, Li N, Haymart M, Kunnimalaiyaan M, Chen H. Valproic Acid Activates Notch1 Signaling and Regulates the Neuroendocrine Phenotype in Carcinoid Cancer Cells. The Oncologist. 2007; 12: 942-951.
  41. Greenblatt DY, Cayo M, Ning L, Jaskula-Sztul, Ndiaye M, Haymart M, Kunnimalaiyaan M, Chen H. Suberoyl Bis-Hydroxamic Acid (SBHA) Inhibits Proliferation by Inducing Cell Cycle Arrest in Carcinoid Cancer Cells. J Gastrointest Surg. 2007; 11:1515-1520.
  42. Kunnimalaiyaan M, Ndiaye MA, Chen H. Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways. Surgery. 2007; 142:959-964.
  43. Chen H. Therapeutic options for patients with metastatic gastrointestinal carcinoid. Journal of Surgical Oncology. 2008; 97:203-204.
  44. Ning L, Greenblatt DY, Kunnimalaiyaan M, Chen H. Suberoyl Bis-Hydroxamic Acid Activates Notch 1 Signaling and Induces Apoptosis in Medullary Thyroid Carcinoma Cells. The Oncologist. 2008; 13:98-104.
  45. Greenblatt DY, Cayo M, Adler JT, Ning L, Haymart M, Kunnimalaiyaan M, Chen H. Valproic Acid Activates Notch1 Signaling and Induces Apoptosis in Medullary Thyroid Cancer Cells.  Ann Surg. 2008; 247:1036-1040.
  46. Deming D, Geiger P, Chen H, Vaccaro A, Kunnimalaiyaan M, and Holen K.  ZM336372, A Raf-1 Activator, Causes Suppression of Proliferation in a Human Hepatocellular Carcinoma Cell Line. J Gastrointest Surg. 2008; 12:852-857.
  47. Lairmore TC, Chen H. The Role of Menin in Neuroendocrine Tumorigenesis. In:  Balogh K, Patócs A, eds. Molecular mechanisms of MEN 1 syndrome (in press).
  48. Platta CS, Greenblatt DY, Kunnimalaiyaan M, Chen H.  Valproic Acid Induces Notch1 Signaling in Small Cell Lung Cancer Cells. Journal of Surgical Research. 2008; 148:31-37.
  49. Ning L, Jaskula-Sztul R, Kunnimalaiyaan M, Chen H. Suberoyl bishydroxamic acid activates Notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma. Annals of Surgical Oncology. 2008; 15:2600-2605.
  50. Pinchot SN, Pitt SC, Sippel RS, Kunnimalaiyaan M, Chen H. Novel targets for the treatment and palliation of gastrointestinal neuroendocrine tumors. Current Opinion in Investigational Drugs 2008;  9:576-82.
  51. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Histone deacetylase inhibitors upregulate Notch1 and inhibit growth in pheochromocytoma cells. Surgery. 2008; 144:956-961.
  52. Ning L, Kunnimalaiyaan M, Chen H. Regulation of cell-cell contact molecules and the metastatic phenotype of medullary thyroid carcinoma by the Raf-1/MEK/ERK pathway. Surgery. 2008; 144: 920-925.
    53.
  53. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitors and lithium chloride. Journal of Surgical Research (in press).
  54. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Combination therapy with histone deacetylase inhibitors and lithium chloride: a novel treatment for carcinoid tumors. Annals of Surgical Oncology. 2009; 16:481-486.
  55. Pinchot SN, Adler JT, Luo Y, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H. Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway. Am. J. Surg. 2009; 197:313-319.
  56. Pinchot SN, Holen KD, Sippel RS, Chen H. Carcinoid Tumors. The Oncologist. 2008; 13: 1255-1269.
  57. Cayo M, Greenblatt DY, Kunnimalaiyaan M, Chen H. Carcinoid Tumors. Atlas Genet Cytogenet Oncol Haematol. May 2008.
  58. Pitt SC, Chen H. Book review: The ABSITE Review, Second Edition. Journal of Surgical Research 2008; 150: 153-154.
  59. Pitt SC, Chen H. Carcinoid Tumors. In Morita SY, Dackiw AB, Zeiger MA, eds. Manual of Endocrine Surgery. (in press).
  60. Xiao X, Ning L, Ndiaye MA, Chen H.  Notch1 Mediates Growth Suppression of Papillary and Follicular Thyroid Cancer Cells by HDAC Inhibitors. Molecular Cancer Therapeutics 2009; 8:350-356.
  61. Cayo MA, Cayo AK, Jarjour SM, Chen H. Sodium butyrate activates Notch1 signaling, reduces tumor markers, and induces cell cycle arrest and apoptosis in pheochromocytoma.  American Journal of Translational Research. 2009; 1:178-183.
  62. Pitt SC, Davis R, Kunnimalaiyaan M, Chen H. AKT and PTEN expression in human gastrointestinal carcinoid tumors. American Journal of Translational Research. 2009; 1:291-299.
  63. Adler JT, Cook M, Luo Y, Pitt SC, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of GSK-3ß. Molecular Cancer Therapeutics 2009; 8:914-920.
  64. Pitt SC, Chen H. The phosphatidylinositol 3-kinase/akt signaling pathway in medullary thyroid cancer. Surgery. 2008; 144:721-724.
  65. Pinchot SN, Sippel RS, Chen H. Multi-targeted approach in the treatment of thyroid cancer. Therapeutics and Clinical Risk Management. 2008; 4:1-13.
  66. Stoll SJ, Pitt SC, Chen H. Follicular Thyroid Cancer Growth Inhibition by Proteosome Inhibitor MG132. Journal of Surgical Research (in press).
  67. Chen JY, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H. MG-132 Inhibits Carcinoid Growth and Alters the Neuroendocrine Phenotype. Journal of Surgical Research (in press).
  68. Lairmore TC, Chen H. The Role of Menin in Neuroendocrine Tumorigenesis. In: Balogh K, Patócs A, eds. Molecular mechanisms of MEN 1 syndrome (in press).
  69. Pitt SC, Chen H. Carcinoid Tumors. In Morita SY, Dackiw AB, Zeiger MA, eds. Manual of Endocrine Surgery. (in press).
  70. Pitt SC, Chen H, Kunnimalaiyaan M. Phosphatidylinositol 3-Kinase-Akt Signaling in Pulmonary Carcinoid Cells. Journal of the American College of Surgeons. 2009; 209:82-88.
  71. Chen JY, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H. MG-132 Inhibits Carcinoid Growth and Alters the Neuroendocrine Phenotype. Journal of Surgical Research (in press).
  72. Pitt SC, Chen H, Kunnimalaiyaan M. Inhibition of Phosphatidylinositol 3-Kinase/Akt Signaling Suppresses Tumor Cell Proliferation and Neuroendocrine Marker Expression in GI Carcinoid Tumors. Annals of Surgical Oncology. 2009; 16:2936-2942.
  73. Ning L, Wentworth L, Chen H, Weber SM. Down-Regulation of Notch1 Signaling Inhibits Tumor Growth in Human Hepatocellular Carcinoma. American Journal of Translational Research. 2009; 1:358-366.
  74. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Inhibition of the PI3K pathway suppresses hormonal secretion and limits growth in pheochromocytoma cells. World Journal of Surgery (in press).
  75. Cook MR, Luo J, Ndiaye M, Chen H, Kunnimalaiyaan M. Xanthohumol Inhibits the Neuroendocrine Transcription Factor Achaete-Scute Complex-Like 1, Suppresses Proliferation and Induces Phosphorylated ERK1/2 in Medullary Thyroid Cancer. Am. J. Surg. (in press).
  76. Cook MR, Chen H. Notch in Normal and Malignant Endocrine Growth and Development. In Bocchetta M, Osipio C, eds. Notch and Cancer (in press).

jvg

 

First published: 10/03/03 Last updated: 11/23/09 webmaster@surgery.wisc.edu
Copyright © 2007 The Board of Regents of the University of Wisconsin System