A Quantitive Animal Model of Tumor-Induced Immunosuppression
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Project Summary:
The failure of many cancer immunotherapy strategies to consistently and reliably inhibit tumor growth is motivating inquiry into the mechanisms by which the interface between tumor cells and the immune system may be uniquely altered. Indeed, disparities in efficacy of these strategies between in vitro and in vivo conditions have led to the study of what is presumed to be an immunosuppressive environment induced by the presence of tumor.1,2 Elucidation of this putative inhibitory influence may be likely to provide a means to optimize tumor-directed immunotherapy.
Any effort to clarify this phenomenon would be greatly facilitated by a reproducible animal model that could (1) confirm a demonstrably immunosuppressive influence created by the presence of tumor; (2) provide a means of quantifying this immunosuppressive influence, and; (3) test the impact of various tumor-directed interventions on the magnitude of this influence. In the present research proposal, we outline a series of experiments that will take advantage of a planned collaborative initiative with three established immunology laboratories (PIs: Paul M. Sondel, MD, Marulasiddappa Suresh, PhD, and Christine M. Seroogy, MD) with complementary areas of experience and expertise who will work with the principal investigator in an effort to demonstrate and investigate an animal model with which the phenomenon of tumor-induced immunosuppression may be confirmed and dissected.
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First published: 07/15/02 Last updated: 11/23/09 webmaster@surgery.wisc.edu
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