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Herb Chen, MD
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M. Kunnimalaiyaan, Ph.D.
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Muthusamy Kunnimalaiyaan, PhD

Senior Scientist, Director,
Endocrine Surgery Research Lab,
Division of General Surgery

K4/643 Clinical Science Center
600 Highland Avenue
Madison, WI 53792-7375

Office: (608) 265-4111

 kunni@surgery.wisc.edu

Education

  • PhD, Indian Agricultural Research Institute, New Delhi, India, 1992

Research Interests

Dr. Kunnimalaiyaan has twelve years of postdoctoral experience in the fields of Biotechnology, microbiology, molecular biology, and Plant biology with eight years of research on DNA replication of both plant and bacteria. His current focus is on the Role of Notch-1 and Ras/raf-1 signaling pathways in Gastrointestinal Neuroendocrine tumors. He has worked on cancer biology/signaling pathways (Notch-1 and Ras/raf-1) since 2001.

Grants

  • Regulating neuroendocrine phenotype in cancer, National Institute of Health R01, Co-investigator, 2006-2011
  • Molecular targeting therapy for pancreatic cancer, University of Wisconsin Foundation, 2006
  • Role of lithium chloride in tumor suppression of neuroendocrine, Robert Draper Technology Innovation Award, 2005
  • Construction of Stable but Inducible Notch-1 and its Role in Medullary Thyroid Cancer, Medical School Research Committee, 2003-2004

Recent Publications

  • Platta CS, Greenblatt DY, Kunnimalaiyaan M, Chen H. Valproic acid induces Notch1 signaling in small cell lung cancer cells., J. Surg. Res. 2008 Jul;148(1):31-7.
    [PubMed ID: 18570928]
  • Greenblatt DY, Cayo MA, Adler JT, Ning L, Haymart MR, Kunnimalaiyaan M, Chen H. Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells., Ann. Surg. 2008 Jun;247(6):1036-40.
    [PubMed ID: 18520232]
  • Pinchot SN, Pitt SC, Sippel RS, Kunnimalaiyaan M, Chen H. Novel targets for the treatment and palliation of gastrointestinal neuroendocrine tumors., Current opinion in investigational drugs (London, England : 2000). 2008 Jun;9(6):576-82.
    [PubMed ID: 18516757]
  • Ning L, Jaskula-Sztul R, Kunnimalaiyaan M, Chen H. Suberoyl Bishydroxamic Acid Activates Notch1 Signaling and Suppresses Tumor Progression in an Animal Model of Medullary Thyroid Carcinoma., Ann. Surg. Oncol. 2008 Jun 18;():.
    [PubMed ID: 18563491]
  • Deming D, Geiger P, Chen H, Vaccaro A, Kunnimalaiyaan M, Holen K. ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line., J. Gastrointest. Surg. 2008 May;12(5):852-7.
    [PubMed ID: 18299943]
  • All Publications

Awards

Rising Star 1st place award for the best research presentation (Poster), North American Neuroendocrine Tumor Society and Carcinoid Cancer Foundation, Portland, OR, 2006

 

 

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General Surgery University of Wisconsin Department of Surgery
First published: 07/15/02 Last updated: 08/19/08 webmaster@surgery.wisc.edu
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