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Bo Liu, PhD

Contact Dr. Liu

E-mail:
liub@surgery.wisc.edu

Phone:
(608) 263-5931

Mail:
Wisconsin Institutes for Medical Research (WIMR) BLDG. 1485
1111 Highland Avenue
Madison, WI 53705-2275

Bo Liu, PhD

Associate Professor
Division of Vascular Surgery

Education

  • MS, Biology, Beijing University, Beijing, China, 1986
  • PhD, Biochemistry, SUNY Downstate, New York, NY, 1993
  • Postdoctoral fellow, Signal transduction; protein degradation, Columbia University, New York, NY, 1994-1996
  • Postdoctoral fellow, Transcription regulation; signal transduction, Memorial Sloan-Kettering Cancer Center, New York, NY, 1996-1999

Research Interests

A major research goal of Dr. Liu’s lab is to understand the pathophysiology of vascular disease including atherosclerosis, restenosis (intimal hyperplasia) and abdominal aortic aneurysms. Using a combination of molecular, biochemical and genetic approaches, Dr. Liu and her coinvestigators identified several intracellular signaling proteins that are critical in regulation of vascular smooth muscle cells, endothelial cells, fibroblasts and progenitor cells. Current research topics include interaction between smooth muscle cell apoptosis, necrosis, and vascular inflammation; progenitor cell recruitment and differentiation; and signaling pathways underlying apoptosis, necrosis, migration, cytokine expression, and other functions of smooth muscle cells. Additional research interests are gene therapy and nanotechnology. To effectively study human disease, Dr. Liu has established productive collaborations with basic scientists and clinicians from a wide range of scientific and medical disciplines. Dr. Liu is also a devoted mentor, who has created a lab environment that fosters creative thinking, multidisciplinary approaches, independence, and collaboration.

Dr. Bo Liu's Lab

Funding/Grants

Recent Publications
  • TGF-β/Smad3 inhibit vascular smooth muscle cell apoptosis through an autocrine signaling mechanism involving VEGF-A.
    Shi X, Guo LW, Seedial SM, Si Y, Wang B, Takayama T, Suwanabol PA, Ghosh S, DiRenzo D, Liu B, Kent KC
    Cell Death Dis 2014; 5():e1317.
    [PubMed ID: 25010983]
    More Information
  • Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage cytotoxicity in abdominal aortic aneurysm.
    Wang Q, Ren J, Morgan S, Liu Z, Dou C, Liu B
    PLoS ONE 2014; 9(3):e92053.
    [PubMed ID: 24632850, PMC ID: 3954911]
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  • Periadventitial application of rapamycin-loaded nanoparticles produces sustained inhibition of vascular restenosis.
    Shi X, Chen G, Guo LW, Si Y, Zhu M, Pilla S, Liu B, Gong S, Kent KC
    PLoS ONE 2014; 9(2):e89227.
    [PubMed ID: 24586612, PMC ID: 3931710]
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  • Protein kinase C-δ (PKCδ) regulates proinflammatory chemokine expression through cytosolic interaction with the NF-κB subunit p65 in vascular smooth muscle cells.
    Ren J, Wang Q, Morgan S, Si Y, Ravichander A, Dou C, Kent KC, Liu B
    J. Biol. Chem. 2014 Mar 28; 289(13):9013-26.
    [PubMed ID: 24519937, PMC ID: 3979373]
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  • Local drug delivery to prevent restenosis.
    Seedial SM, Ghosh S, Saunders RS, Suwanabol PA, Shi X, Liu B, Kent KC
    J. Vasc. Surg. 2013 May; 57(5):1403-14.
    [PubMed ID: 23601595, PMC ID: 3635112]
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  • Preferential secretion of collagen type 3 versus type 1 from adventitial fibroblasts stimulated by TGF-β/Smad3-treated medial smooth muscle cells.
    Goel SA, Guo LW, Shi XD, Kundi R, Sovinski G, Seedial S, Liu B, Kent KC
    Cell. Signal. 2013 Apr; 25(4):955-60.
    [PubMed ID: 23280188, PMC ID: 3595331]
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  • Reduction of intimal hyperplasia in injured rat arteries promoted by catheter balloons coated with polyelectrolyte multilayers that contain plasmid DNA encoding PKCδ.
    Bechler SL, Si Y, Yu Y, Ren J, Liu B, Lynn DM
    Biomaterials 2013 Jan; 34(1):226-36.
    [PubMed ID: 23069712, PMC ID: 3483441]
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  • Prenatal exposure to pesticide ingredient piperonyl butoxide and childhood cough in an urban cohort.
    Liu B, Jung KH, Horton MK, Camann DE, Liu X, Reardon AM, Perzanowski MS, Zhang H, Perera FP, Whyatt RM, Miller RL
    Environ Int 2012 Nov 1; 48():156-61.
    [PubMed ID: 22935766, PMC ID: 3440511]
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  • Mechanisms of post-intervention arterial remodelling.
    Goel SA, Guo LW, Liu B, Kent KC
    Cardiovasc. Res. 2012 Dec 1; 96(3):363-71.
    [PubMed ID: 22918976, PMC ID: 3500049]
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  • Elevated protein kinase C-δ contributes to aneurysm pathogenesis through stimulation of apoptosis and inflammatory signaling.
    Morgan S, Yamanouchi D, Harberg C, Wang Q, Keller M, Si Y, Burlingham W, Seedial S, Lengfeld J, Liu B
    Arterioscler. Thromb. Vasc. Biol. 2012 Oct; 32(10):2493-502.
    [PubMed ID: 22879584, PMC ID: 3442600]
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