Skip to Content
Bo Liu, PhD

Contact Dr. Liu

E-mail:
liub@surgery.wisc.edu

Phone:
(608) 263-5931

Mail:
Wisconsin Institutes for Medical Research (WIMR) BLDG. 1485
1111 Highland Avenue
Madison, WI 53705-2275

Bo Liu, PhD

Associate Professor
Division of Vascular Surgery

Education

  • MS, Biology, Beijing University, Beijing, China, 1986
  • PhD, Biochemistry, SUNY Downstate, New York, NY, 1993
  • Postdoctoral fellow, Signal transduction; protein degradation, Columbia University, New York, NY, 1994-1996
  • Postdoctoral fellow, Transcription regulation; signal transduction, Memorial Sloan-Kettering Cancer Center, New York, NY, 1996-1999

Research Interests

A major research goal of Dr. Liu’s lab is to understand the pathophysiology of vascular disease including atherosclerosis, restenosis (intimal hyperplasia) and abdominal aortic aneurysms. Using a combination of molecular, biochemical and genetic approaches, Dr. Liu and her coinvestigators identified several intracellular signaling proteins that are critical in regulation of vascular smooth muscle cells, endothelial cells, fibroblasts and progenitor cells. Current research topics include interaction between smooth muscle cell apoptosis and vascular inflammation, progenitor cell recruitment and differentiation, signaling pathways underlying apoptosis, migration, cytokine expression and other functions of smooth muscle cells. Additional research interests are gene therapy and nanotechnology. To effectively study human disease, Dr. Liu has established productive collaborations with basic scientists and clinicians from a wide range of scientific and medical disciplines. Dr. Liu is also a devoted mentor, who has created a lab environment that fosters creative thinking, multidisciplinary approaches, independence, and collaboration.

Dr. Bo Liu's Lab

Funding/Grants
  • Molecular mechanisms of abdominal aortic aneurysms
    Funding Agency: National Institutes of Health
    Principal Investigator(s): Bo Liu, PhD
    More Information
  • Multifunctional polymer nanoparticules for targeted drug delivery: new approaches to treat aneurysm
    Funding Agency: The UW Graduate School
    Principal Investigator(s): Bo Liu, PhD
    More Information
  • Surgery Summer Research Experience for Medical Students
    Funding Agency: National Institutes of Health
    Principal Investigator(s): Herbert Chen, MD, Bo Liu, PhD
    More Information

Recent Publications
  • Local drug delivery to prevent restenosis.
    Seedial SM, Ghosh S, Saunders RS, Suwanabol PA, Shi X, Liu B, Kent KC
    J. Vasc. Surg. 2013 May; 57(5):1403-14.
    [PubMed ID: 23601595, PMC ID: 3635112]
    More Information
  • Preferential secretion of collagen type 3 versus type 1 from adventitial fibroblasts stimulated by TGF-β/Smad3-treated medial smooth muscle cells.
    Goel SA, Guo LW, Shi XD, Kundi R, Sovinski G, Seedial S, Liu B, Kent KC
    Cell. Signal. 2013 Apr; 25(4):955-60.
    [PubMed ID: 23280188, PMC ID: 3595331]
    More Information
  • Prenatal exposure to pesticide ingredient piperonyl butoxide and childhood cough in an urban cohort.
    Liu B, Jung KH, Horton MK, Camann DE, Liu X, Reardon AM, Perzanowski MS, Zhang H, Perera FP, Whyatt RM, Miller RL
    Environ Int 2012 Nov 1; 48():156-61.
    [PubMed ID: 22935766, PMC ID: 3440511]
    More Information
  • Accelerated aneurysmal dilation associated with apoptosis and inflammation in a newly developed calcium phosphate rodent abdominal aortic aneurysm model.
    Yamanouchi D, Morgan S, Stair C, Seedial S, Lengfeld J, Kent KC, Liu B
    J. Vasc. Surg. 2012 Aug; 56(2):455-61.
    [PubMed ID: 22560311, PMC ID: 3408782]
    More Information
  • Transforming growth factor-β increases vascular smooth muscle cell proliferation through the Smad3 and extracellular signal-regulated kinase mitogen-activated protein kinases pathways.
    Suwanabol PA, Seedial SM, Shi X, Zhang F, Yamanouchi D, Roenneburg D, Liu B, Kent KC
    J. Vasc. Surg. 2012 Aug; 56(2):446-54.
    [PubMed ID: 22521802, PMC ID: 3408812]
    More Information
  • Protein kinase C δ regulates the release of collagen type I from vascular smooth muscle cells via regulation of Cdc42.
    Lengfeld J, Wang Q, Zohlman A, Salvarezza S, Morgan S, Ren J, Kato K, Rodriguez-Boulan E, Liu B
    Mol. Biol. Cell 2012 May; 23(10):1955-63.
    [PubMed ID: 22456512, PMC ID: 3350558]
    More Information
  • TGF-β and Smad3 modulate PI3K/Akt signaling pathway in vascular smooth muscle cells.
    Suwanabol PA, Seedial SM, Zhang F, Shi X, Si Y, Liu B, Kent KC
    Am. J. Physiol. Heart Circ. Physiol. 2012 Jun 1; 302(11):H2211-9.
    [PubMed ID: 22447946, PMC ID: 3378292]
    More Information
  • Protein kinase C-delta mediates adventitial cell migration through regulation of monocyte chemoattractant protein-1 expression in a rat angioplasty model.
    Si Y, Ren J, Wang P, Rateri DL, Daugherty A, Shi XD, Kent KC, Liu B
    Arterioscler. Thromb. Vasc. Biol. 2012 Apr; 32(4):943-54.
    [PubMed ID: 22328773, PMC ID: 3311123]
    More Information
  • The novel function of advanced glycation end products in regulation of MMP-9 production.
    Zhang F, Banker G, Liu X, Suwanabol PA, Lengfeld J, Yamanouchi D, Kent KC, Liu B
    J. Surg. Res. 2011 Dec; 171(2):871-6.
    [PubMed ID: 20638679, PMC ID: 3623272]
    More Information
  • The serotonin1A receptor gene as a genetic and prenatal maternal environmental factor in anxiety.
    Gleason G, Liu B, Bruening S, Zupan B, Auerbach A, Mark W, Oh JE, Gal-Toth J, Lee F, Toth M
    Proc. Natl. Acad. Sci. U.S.A. 2010 Apr 20; 107(16):7592-7.
    [PubMed ID: 20368423, PMC ID: 2867748]
    More Information

webmaster@surgery.wisc.edu Copyright © 2013 The Board of Regents of the University of Wisconsin System