Education

• MS, Biology, Beijing University, Beijing, China, 1986
• PhD, Biochemistry, SUNY Downstate, New York, NY, 1993
• Postdoctoral fellow, Signal transduction; protein degradation, Columbia University, New York, NY, 1994-1996
• Postdoctoral fellow, Transcription regulation; signal transduction, Memorial Sloan-Kettering Cancer Center, New York, NY, 1996-1999

Research Interests

Dr. Liu and her long-term research partner, Department of Surgery Chair Dr. Craig Kent, have built a multi-disciplinary vascular research team that focuses on investigations that are basic, translational and clinical. Their basic research efforts involve three broad areas: Molecular mechanism underlying vascular inflammation, molecular mechanism underlying occlusive vascular diseases, and development of new materials for biomedical applications (gene delivery and vascular grafts). Specifically, Dr. Liu’s group has identified an intracellular signaling protein called protein kinase C-delta (PKCδ) as a key regulator for apoptosis of vascular smooth muscle cells. The potential role of PKCδ in the pathogenesis of intimal hyperplasia or abdominal aortic aneurysms are being investigated.

Dr. Bo Liu's Lab

Recent Publications

• High-throughput illumina strand-specific RNA sequencing library preparation.
  Zhong S, Joung JG, Zheng Y, Chen YR, Liu B, Shao Y, Xiang JZ, Fei Z, Giovannoni JJ
  Cold Spring Harb Protoc 2011 Aug; 2011(8):940-9.
  [PubMed ID: 21807852]
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• Interleukin-15:Interleukin-15 receptor α scaffold for creation of multivalent targeted immune molecules.
  Wong RL, Liu B, Zhu X, You L, Kong L, Han KP, Lee HI, Chavaillaz PA, Jin M, Wang Y, Rhode PR, Wong HC
  Protein Eng. Des. Sel. 2011 Apr; 24(4):373-83.
  [PubMed ID: 21177283, PMC ID: 3049345]
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• The serotonin1A receptor gene as a genetic and prenatal maternal environmental factor in anxiety.
  Gleason G, Liu B, Bruening S, Zupan B, Auerbach A, Mark W, Oh JE, Gal-Toth J, Lee F, Toth M
  Proc. Natl. Acad. Sci. U.S.A. 2010 Apr 20; 107(16):7592-7.
  [PubMed ID: 20368423, PMC ID: 2867748]
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• Arterial gene transfer of the TGF-beta signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGF.
  Kundi R, Hollenbeck ST, Yamanouchi D, Herman BC, Edlin R, Ryer EJ, Wang C, Tsai S, Liu B, Kent KC
  Cardiovasc. Res. 2009 Nov 1; 84(2):326-35.
  [PubMed ID: 19570811, PMC ID: 2761202]
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• TGF-beta through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation.
  Tsai S, Hollenbeck ST, Ryer EJ, Edlin R, Yamanouchi D, Kundi R, Wang C, Liu B, Kent KC
  Am. J. Physiol. Heart Circ. Physiol. 2009 Aug; 297(2):H540-9.
  [PubMed ID: 19525370, PMC ID: 2724222]
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