Contact Dr. Al-Adra
David P. Al-Adra, MD, PhD
Dr. Al-Adra is certified by the American Board of Surgery (ABS), the American Society of Transplant Surgeons (ASTS), the Royal College of Surgeons of Canada, and the Americas Hepato-Pancreato-Biliary Association (AHPBA). He specializes in liver, kidney, pancreas and pediatric transplantation, live donor liver transplantation (LDLT), and hepatobiliary surgery.
Dr. Al-Adra provides a wide range of services including Kidney Transplant, Laparoscopic Donor Nephrectomy, Liver Resection, Liver Transplant, Pancreas Transplant, Pediatric Liver Transplant, and Wedge Resection of the Liver.
Dr. Al-Adra aims to investigate the mechanisms of immunological tolerance and attempt to induce tolerance to transplanted organs through organ pre-treatment and recipient preconditioning. The overall goal is to decrease immunity and promote tolerance towards solid organ transplants in order to decrease the need for immunosuppressive therapy. Specifically, this would involve investigating the cell surface expression of co-inhibitory and co-stimulatory structures of hepatocytes using flow cytometry. Modification of the expression of these surface molecules will then be done to promote co-inhibition and enhance immunological regulation. Ex-vivo perfusion technologies will allow investigation of different reagents and delivery systems used for whole organ modification. Further investigation would include evaluating the effect on the vascular microenvironment and local immune infiltration using cellular imaging.