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David P. Al-Adra, MD, PhD

Contact Dr. Al-Adra

E-mail:
aladra@surgery.wisc.edu

Phone:
(608) 265-6471

Mail:
600 HIGHLAND AVE
MADISON, WI 53792-0001

David P. Al-Adra, MD, PhD

Assistant Professor
Division of Transplantation

Education

  • MD, University of Alberta, 2007
  • PhD, Clinical Investigator Program in the Department of Surgery, University of Alberta, 2012
  • Residency, General Surgery, University of Alberta, 2015
  • Abdominal Organ Transplant Fellowship, University of Toronto, 2017

Clinical Specialties

Dr. Al-Adra is certified by the American Board of Surgery (ABS), the American Society of Transplant Surgeons (ASTS), the Royal College of Surgeons of Canada, and the Americas Hepato-Pancreato-Biliary Association (AHPBA). He specializes in liver, kidney, pancreas and pediatric transplantation, live donor liver transplantation (LDLT), and hepatobiliary surgery.

Dr. Al-Adra provides a wide range of services including Kidney Transplant, Laparoscopic Donor Nephrectomy, Liver Resection, Liver Transplant, Pancreas Transplant, Pediatric Liver Transplant, and Wedge Resection of the Liver.

Research Interests

Dr. Al-Adra aims to investigate the mechanisms of immunological tolerance and attempt to induce tolerance to transplanted organs through organ pre-treatment and recipient preconditioning. The overall goal is to decrease immunity and promote tolerance towards solid organ transplants in order to decrease the need for immunosuppressive therapy. Specifically, this would involve investigating the cell surface expression of co-inhibitory and co-stimulatory structures of hepatocytes using flow cytometry. Modification of the expression of these surface molecules will then be done to promote co-inhibition and enhance immunological regulation. Ex-vivo perfusion technologies will allow investigation of different reagents and delivery systems used for whole organ modification. Further investigation would include evaluating the effect on the vascular microenvironment and local immune infiltration using cellular imaging.

Recent Publications
  • Single-donor islet transplantation and long-term insulin independence in select patients with type 1 diabetes mellitus.
    Al-Adra DP, Gill RS, Imes S, O'Gorman D, Kin T, Axford SJ, Shi X, Senior PA, Shapiro AM
    Transplantation 2014 Nov 15; 98(9):1007-12.
    [PubMed ID: 24911037]
    More Information
  • Treatment of unresectable intrahepatic cholangiocarcinoma with yttrium-90 radioembolization: a systematic review and pooled analysis.
    Al-Adra DP, Gill RS, Axford SJ, Shi X, Kneteman N, Liau SS
    Eur J Surg Oncol 2015 Jan; 41(1):120-7.
    [PubMed ID: 25449754, PMC ID: 4316196]
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  • Targeting cells causing split tolerance allows fully allogeneic islet survival with minimal conditioning in NOD mixed chimeras.
    Al-Adra DP, Pawlick R, Shapiro AM, Anderson CC
    Am. J. Transplant. 2012 Dec; 12(12):3235-45.
    [PubMed ID: 22974315]
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  • Single-incision appendectomy is comparable to conventional laparoscopic appendectomy: a systematic review and pooled analysis.
    Gill RS, Shi X, Al-Adra DP, Birch DW, Karmali S
    Surg Laparosc Endosc Percutan Tech 2012 Aug; 22(4):319-27.
    [PubMed ID: 22874680]
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  • Predictors of attrition in a multidisciplinary adult weight management clinic.
    Gill RS, Karmali S, Hadi G, Al-Adra DP, Shi X, Birch DW
    Can J Surg 2012 Aug; 55(4):239-43.
    [PubMed ID: 22617538, PMC ID: 3404143]
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  • Nonobese diabetic natural killer cells: a barrier to allogeneic chimerism that can be reduced by rapamycin.
    Al-Adra DP, Chan WF, Anderson CC
    Transplantation 2011 Nov 15; 92(9):977-84.
    [PubMed ID: 21956197]
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  • The use of bovine pericardial buttress on linear stapler fails to reduce pancreatic fistula incidence in a porcine pancreatic transection model.
    Maciver A, McCall M, Mihalicz D, Al-Adra D, Pawlick R, Shapiro AM
    HPB Surg 2011; 2011():624060.
    [PubMed ID: 22114365, PMC ID: 3202096]
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  • Mixed chimerism and split tolerance: mechanisms and clinical correlations.
    Al-Adra DP, Anderson CC
    Chimerism 2011 Oct-Dec; 2(4):89-101.
    [PubMed ID: 22509425, PMC ID: 3321885]
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  • The benefits of bariatric surgery in obese patients with hip and knee osteoarthritis: a systematic review.
    Gill RS, Al-Adra DP, Shi X, Sharma AM, Birch DW, Karmali S
    Obes Rev 2011 Dec; 12(12):1083-9.
    [PubMed ID: 21883871]
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  • Treatment of gastric cancer with peritoneal carcinomatosis by cytoreductive surgery and HIPEC: a systematic review of survival, mortality, and morbidity.
    Gill RS, Al-Adra DP, Nagendran J, Campbell S, Shi X, Haase E, Schiller D
    J Surg Oncol 2011 Nov 01; 104(6):692-8.
    [PubMed ID: 21713780]
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