Kartik Gupta, MS
Vascular interventions leading to denuded endothelium are a major cause for intimal hyperplasia. The reformation of the plaque that causes narrowing of the vessel — called restenosis — involves proliferation of the smooth muscle cells (SMCs); however, the denuded endothelium and the pro-inflammatory environment also cause cell-death via apoptosis and necroptosis.
Based on recent findings from the Liu lab, Kartik strives to understand the mechanism by which circulating cells help “seal” the denuded endothelium. Towards this, he is using in-vivo and ex-vivo approaches. In addition, he wants to understand whether the kinases pertinent to cell death and stress-response facilitate a phenotypic-switch in vascular SMCs that are activated pathologically.
When he is not studying murine-vasculature, you can find him reading papers over a coffee or running on the Lakeshore Path along Mendota, putting to practical use the principles of a healthy cardiovascular system.