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William J Burlingham, PhD

Contact Dr. Burlingham

E-mail:
burlingham@surgery.wisc.edu

Phone:
(608) 263-0388

Mail:
600 HIGHLAND AVE
BX7375 CLINICAL SCIENCE CNTR-G4
MADISON, WI 53792-3284

William J Burlingham, PhD

Professor
Division of Transplantation

Education

  • PhD, Biology, Syracuse University, Syracuse, NY, 1979
  • Postdoctoral Research Fellowship, National Cancer Institute, Mayo Clinic and Mayo Medical School, Rochester, MN, 1980-1983

Professional Activities

Dr. Burlingham serves on the editorial board of Transplantation. He is also the chairman of the University of Wisconsin Spring Immunology Seminar Series.

Research Interests

Dr. Burlingham has developed a highly respected transplant basic research program that focuses on acquired immunologic tolerance. His laboratory hopes to gain insight into graft acceptance by studying transplant recipients who have survived after stopping immunosuppressive drugs.

Specifically, his research focuses on the natural exchange of soluble antigens and low numbers of white blood cells that occurs between mother and child during pregnancy and nursing. The lab’s working hypothesis is that this exchange, which leads to persistence of bone marrow-derived maternal blood cells within the offspring (“microchimerism”) may induce a “natural” form of tolerance. This tolerance, if harnessed, may allow for drug-free acceptance of transplanted grafts. The other major focus of Dr. Burlingham’s lab is the phenomenon of autoimmunity that develops after lung transplantation. A novel type of T Cells, called Th-17, react to collagen type V and cause inflammation and over-production of collagens causing airway blockage and graft loss. His lab is working on ways to inhibit this process by new forms of immune suppressive drugs and by increasing T regulatory cells that normally prevent autoimmune disease.

View Dr. Burlingham’s Google Scholar Citations Profile.

Dr. Burlingham's Lab

Funding/Grants

Active Clinical Trials

Recent Publications
  • Mucosal administration of collagen V ameliorates atherosclerotic plaque burden by inducing IL-35-dependent tolerance.
    Park AC, Huang G, Jankowska-Gan E, Massoudi D, Kernien JF, Vignali DA, Sullivan JA, Wilkes DS, Burlingham WJ, Greenspan DS
    J. Biol. Chem. 2015 Dec 31.
    [PubMed ID: 26721885]
    More Information
  • Exosomes: The missing link between microchimerism and acquired tolerance?
    Burlingham WJ
    Chimerism 2014 Oct 2; 5(3-4):63-7.
    [PubMed ID: 26679558]
    More Information
  • Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft.
    Kwun J, Farris AB, Song H, Mahle WT, Burlingham WJ, Knechtle SJ
    Transplantation 2015 Dec; 99(12):2485-93.
    [PubMed ID: 26102611]
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  • Bioengineered vocal fold mucosa for voice restoration.
    Ling C, Li Q, Brown ME, Kishimoto Y, Toya Y, Devine EE, Choi KO, Nishimoto K, Norman IG, Tsegyal T, Jiang JJ, Burlingham WJ, Gunasekaran S, Smith LM, Frey BL, Welham NV
    Sci Transl Med 2015 Nov 18; 7(314):314ra187.
    [PubMed ID: 26582902, PMC ID: 4669060]
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  • Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.
    Newell KA, Asare A, Sanz I, Wei C, Rosenberg A, Gao Z, Kanaparthi S, Asare S, Lim N, Stahly M, Howell M, Knechtle S, Kirk A, Marks WH, Kawai T, Spitzer T, Tolkoff-Rubin N, Sykes M, Sachs DH, Cosimi AB, Burlingham WJ, Phippard D, Turka LA
    Am. J. Transplant. 2015 Nov; 15(11):2908-20.
    [PubMed ID: 26461968]
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