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Full Title CARA 4172
Protocol Number
Principal Investigator(s)
Division General Surgery
Status New
Description

Primary Objective:
• To characterize and confirm the analgesic efficacy of different dose levels of CR845 versus placebo in reducing post-operative pain following abdominal surgery.
Secondary Objectives:
• To compare the incidence of post-operative vomiting between CR845 and placebo-treated patients.
• To compare the impact of post-operative nausea and vomiting between CR845 and placebo-treated patients.
• To compare the use of analgesic rescue medications between CR845 and placebo-treated patients.
• To characterize the plasma concentration profile of CR845 at the doses and dose regimens evaluated in this study.
Exploratory Objective:
• To evaluate the effect of CR845 on serum levels of cytokines and other inflammatory biomarkers.

Other Clinical Trials in the Department of Surgery
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