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Authors Aslan IR, Campos GM, Calton MA, Evans DS, Merriman RB, Vaisse C
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Journal Obes Surg Volume: 21 Issue: 7 Pages: 930-4
Publish Date 2011 Jul
PubMed ID 20957447
PMC ID 3119798

Heterozygous mutations in melanocortin-4 receptor (MC4R) are the most frequent genetic cause of obesity. Bariatric surgery is a successful treatment for severe obesity. The mechanisms of weight loss after bariatric surgery are not well understood.Ninety-two patients who had Roux-en-Y gastric bypass (RYGB) surgery were screened for MC4R mutations. We compared percent excess weight loss (%EWL) in the four MC4R mutation carriers with that of two control groups: 8 matched controls and with the remaining 80 patients who underwent RYGB.Four patients were heterozygous for functionally significant MC4R mutations. In patients with MC4R mutations, the EWL after RYGB (66 EWL) was not significantly different compared to matched controls (70% EWL) and non-matched controls (60% EWL) after 1 year of follow-up.This study suggests that patients with heterozygous MC4R mutations also benefit from RYGB and that weight loss may be independent of the presence of such mutations.

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