Skip to Content
Authors Fraser JD, Aguayo P, Leys CM, Keckler SJ, Newland JG, Sharp SW, Murphy JP, Snyder CL, Sharp RJ, Andrews WS, Holcomb GW, Ostlie DJ, St Peter SD
Author Profile(s)
Journal J. Pediatr. Surg. Volume: 45 Issue: 6 Pages: 1198-202
Publish Date 2010 Jun
PubMed ID 20620320

In a previous prospective randomized trial, we found a once-a-day regimen of ceftriaxone and metronidazole to be an efficient, cost-effective treatment for children with perforated appendicitis. In this study, we evaluated the safety of discharging patients to complete an oral course of antibiotics.Children found to have perforated appendicitis at the time of laparoscopic appendectomy were enrolled in the study. Perforation was defined as a hole in the appendix or fecalith in the abdomen. Patients were randomized to antibiotic treatment with either once daily dosing of ceftriaxone and metronidazole for a minimum of 5 days (intravenous [IV] arm) or discharge to home on oral amoxicillin/clavulanate when tolerating a regular diet (IV/PO arm) to complete 7 days.One hundred two patients underwent laparoscopic appendectomy for perforated appendicitis. On presentation, there were no differences in age, weight, sex distribution, days of symptoms, maximum temperature, or leukocyte count between the 2 groups. There was no difference in the postoperative abscess rate between the two treatment groups. Discharge was possible before day 5 in 42% of the patients in the IV/PO arm.When patients are able to tolerate a regular diet, completing the course of antibiotics orally decreases hospitalization with no effect on the risk of postoperative abscess formation. Copyright © 2016 The Board of Regents of the University of Wisconsin System