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Authors Sullivan JA, Adams AB, Burlingham WJ
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Journal Transplantation Volume: 97 Issue: 5 Pages: 483-9
Publish Date 2014 Mar 15
PubMed ID 24212502

While transplantation research continues to focus on the development of Treg-sparing and plasma cell/B-cell-targeting strategies to improve long-term outcomes, little attention has been paid to the emerging role of the TH17 cell in mediating chronic rejection. This review aimed to summarize the recent emergence of the TH17 and the newly described TH1/17 cell as major players in transplantation and to suggest ways of improving graft outcome through TH17-targeted immunosuppression. Copyright © 2017 The Board of Regents of the University of Wisconsin System