|Authors||Cullins MJ, Connor NP|
|Publish Date||2017 Feb 09|
Age-related decline in the intrinsic lingual musculature could contribute to swallowing disorders, yet the effects of age on these muscles is unknown. We hypothesized reduced muscle fiber size and shifts to slower MyHC fiber types with age.Intrinsic lingual muscles were sampled from 8 young-adult (9 months) and 8 old (32 months) Fischer 344/Brown Norway rats. Fiber size and MyHC were determined by fluorescent immunohistochemistry.Age was associated with a reduced abundance of rapidly-contracting muscle fibers, and more slowly-contracting fibers. Decreased fiber size was found only in the transverse and verticalis muscles.Shifts in muscle composition from faster to slower MyHC fiber types may contribute to age-related changes in swallowing duration. Decreasing muscle fiber size in the protrusive transverse and verticalis muscles may contribute to reductions in maximum isometric tongue pressure found with age. Differences among regions and muscles may be associated with different functional demands. This article is protected by copyright. All rights reserved.