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1.  Mohammed TA, Holen KD, Jaskula-Sztul R, Mulkerin D, Lubner SJ, Schelman WR, Eickhoff J, Chen H, LoConte NK. A Pilot Phase II Study of Valproic Acid for Treatment of Low-Grade Neuroendocrine Carcinoma. The Oncologist (in press). NIHMS290131

1. Phan T, Yu XM, Kunnimalaiyaan M, Chen H. Antiproliferative effect of chrysin on anaplastic thyroid cancer. J. Surg. Res. 2011 Sep; 170(1):84-8.
[PubMed ID: 21571321, PMCID: 3154442]
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2. Jaskula-Sztul R, Pisarnturakit P, Landowski M, Chen H, Kunnimalaiyaan M. Expression of the active Notch1 decreases MTC tumor growth in vivo. J. Surg. Res. 2011 Nov; 171(1):23-7.
[PubMed ID: 21571316, PMCID: 3157562]
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3. Lubner SJ, Kunnimalaiyaan M, Holen KD, Ning L, Ndiaye M, Loconte NK, Mulkerin DL, Schelman WR, Chen H. A preclinical and clinical study of lithium in low-grade neuroendocrine tumors. Oncologist 2011; 16(4):452-7.
[PubMed ID: 21393344, PMCID: 3119207]
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4. Zarebczan B, Pinchot SN, Kunnimalaiyaan M, Chen H. Hesperetin, a potential therapy for carcinoid cancer. Am. J. Surg. 2011 Mar; 201(3):329-32; discussion 333.
[PubMed ID: 21367373, PMCID: 3073682]
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5. Truong M, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H. Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer. Ann. Surg. Oncol. 2011 May; 18(5):1506-11.
[PubMed ID: 21184191, PMCID: 3078954]
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6. Zarebczan B, Chen H. Signaling mechanisms in neuroendocrine tumors as targets for therapy. Endocrinol. Metab. Clin. North Am. 2010 Dec; 39(4):801-10.
[PubMed ID: 21095546, PMCID: 3011942]
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7. Pinchot SN, Jaskula-Sztul R, Ning L, Peters NR, Cook MR, Kunnimalaiyaan M, Chen H. Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method. Cancer 2011 Apr 1; 117(7):1386-98.
[PubMed ID: 21425138, PMCID: 3117093]
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8. Meyer-Rochow GY, Jackson NE, Conaglen JV, Whittle DE, Kunnimalaiyaan M, Chen H, Westin G, Sandgren J, Stålberg P, Khanafshar E, Shibru D, Duh QY, Clark OH, Kebebew E, Gill AJ, Clifton-Bligh R, Robinson BG, Benn DE, Sidhu SB. MicroRNA profiling of benign and malignant pheochromocytomas identifies novel diagnostic and therapeutic targets. Endocr. Relat. Cancer 2010 Sep; 17(3):835-46.
[PubMed ID: 20621999]
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9. Chen H, Sippel RS, O'Dorisio MS, Vinik AI, Lloyd RV, Pacak K, . The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas 2010 Aug; 39(6):775-83.
[PubMed ID: 20664475]
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10. Greenblatt DY, Ndiaye M, Chen H, Kunnimalaiyaan M. Lithium inhibits carcinoid cell growth in vitro. Am J Transl Res 2010; 2(3):248-53.
[PubMed ID: 20589165, PMCID: 2892410]
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11. Ning L, Chen H, Kunnimalaiyaan M. Focal adhesion kinase, a downstream mediator of Raf-1 signaling, suppresses cellular adhesion, migration, and neuroendocrine markers in BON carcinoid cells. Mol. Cancer Res. 2010 May; 8(5):775-82.
[PubMed ID: 20407018, PMCID: 2872724]
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12. Alexander VM, Roy M, Steffens KA, Kunnimalaiyaan M, Chen H. Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoids. Int J Clin Exp Med 2010; 3(2):95-102.
[PubMed ID: 20607034, PMCID: 2894643]
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13. Cook MR, Luo J, Ndiaye M, Chen H, Kunnimalaiyaan M. Xanthohumol inhibits the neuroendocrine transcription factor achaete-scute complex-like 1, suppresses proliferation, and induces phosphorylated ERK1/2 in medullary thyroid cancer. Am. J. Surg. 2010 Mar; 199(3):315-8; discussion 318.
[PubMed ID: 20226902, PMCID: 2841322]
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14. Adler JT, Chen H. Is endocrine surgery research dying? Am J Transl Res 2010; 2(2):129-34.
[PubMed ID: 20407602, PMCID: 2855631]
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15. Cook M, Yu XM, Chen H. Notch in the development of thyroid C-cells and the treatment of medullary thyroid cancer. Am J Transl Res 2010; 2(1):119-25.
[PubMed ID: 20182588, PMCID: 2826828]
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16. Zarebczan B, Chen H. Multi-targeted approach in the treatment of thyroid cancer. Minerva Chir 2010 Feb; 65(1):59-69.
[PubMed ID: 20212418, PMCID: 2901507]
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17. Cook MR, Pinchot SN, Jaskula-Sztul R, Luo J, Kunnimalaiyaan M, Chen H. Identification of a novel Raf-1 pathway activator that inhibits gastrointestinal carcinoid cell growth. Mol. Cancer Ther. 2010 Feb; 9(2):429-37.
[PubMed ID: 20103603, PMCID: 2820603]
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18. Chen JY, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H. MG-132 inhibits carcinoid growth and alters the neuroendocrine phenotype. J. Surg. Res. 2010 Jan; 158(1):15-9.
[PubMed ID: 19765735, PMCID: 2795050]
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19. Pinchot SN, Kunnimalaiyaan M, Sippel RS, Chen H. Medullary thyroid carcinoma: targeted therapies and future directions. J Oncol 2009; 2009():183031.
[PubMed ID: 20069043, PMCID: 2798103]
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20. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Inhibition of the PI3K pathway suppresses hormonal secretion and limits growth in pheochromocytoma cells. World J Surg 2009 Nov; 33(11):2452-7.
[PubMed ID: 19669229, PMCID: 3088764]
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21. Deming D, Geiger P, Chen H, Kunnimalaiyaan M, Holen K. ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. J. Surg. Res. 2010 Jun 1; 161(1):28-32.
[PubMed ID: 20031160]
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22. Ning L, Wentworth L, Chen H, Weber SM. Down-regulation of Notch1 signaling inhibits tumor growth in human hepatocellular carcinoma. Am J Transl Res 2009; 1(4):358-66.
[PubMed ID: 19956448, PMCID: 2780034]
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23. Pitt SC, Chen H, Kunnimalaiyaan M. Inhibition of phosphatidylinositol 3-kinase/Akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors. Ann. Surg. Oncol. 2009 Oct; 16(10):2936-42.
[PubMed ID: 19588205, PMCID: 2917194]
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24. Stoll SJ, Pitt SC, Chen H. Follicular thyroid cancer cell growth inhibition by proteosome inhibitor MG132. J. Surg. Res. 2009 Sep; 156(1):39-44.
[PubMed ID: 19552924, PMCID: 2730430]
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25. Pitt SC, Chen H, Kunnimalaiyaan M. Phosphatidylinositol 3-kinase-Akt signaling in pulmonary carcinoid cells. J. Am. Coll. Surg. 2009 Jul; 209(1):82-8.
[PubMed ID: 19651067, PMCID: 2910111]
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26. Adler JT, Cook M, Luo Y, Pitt SC, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. Mol. Cancer Ther. 2009 Apr; 8(4):914-20.
[PubMed ID: 19372564, PMCID: 2670470]
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27. Pinchot SN, Adler JT, Luo Y, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H. Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway. Am. J. Surg. 2009 Mar; 197(3):313-9.
[PubMed ID: 19245907, PMCID: 2664746]
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28. Pitt SC, Davis R, Kunnimalaiyaan M, Chen H. AKT and PTEN expression in human gastrointestinal carcinoid tumors. Am J Transl Res 2009; 1(3):291-9.
[PubMed ID: 19956439, PMCID: 2776321]
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29. Cayo MA, Cayo AK, Jarjour SM, Chen H. Sodium butyrate activates Notch1 signaling, reduces tumor markers, and induces cell cycle arrest and apoptosis in pheochromocytoma. Am J Transl Res 2009; 1(2):178-83.
[PubMed ID: 19956429, PMCID: 2776315]
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30. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Histone deacetylase inhibitors upregulate Notch-1 and inhibit growth in pheochromocytoma cells. Surgery 2008 Dec; 144(6):956-61; discussion 961-2.
[PubMed ID: 19041003, PMCID: 2638099]
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31. Ning L, Kunnimalaiyaan M, Chen H. Regulation of cell-cell contact molecules and the metastatic phenotype of medullary thyroid carcinoma by the Raf-1/MEK/ERK pathway. Surgery 2008 Dec; 144(6):920-4; discussion 924-5.
[PubMed ID: 19040998, PMCID: 2639554]
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32. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Combination therapy with histone deacetylase inhibitors and lithium chloride: a novel treatment for carcinoid tumors. Ann. Surg. Oncol. 2009 Feb; 16(2):481-6.
[PubMed ID: 19030935, PMCID: 2740795]
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33. Adler JT, Sippel RS, Schaefer S, Chen H. Preserving function and quality of life after thyroid and parathyroid surgery. Lancet Oncol. 2008 Nov; 9(11):1069-75.
[PubMed ID: 19012855]
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34. Pinchot SN, Sippel RS, Chen H. Multi-targeted approach in the treatment of thyroid cancer. Ther Clin Risk Manag 2008 Oct; 4(5):935-47.
[PubMed ID: 19209276, PMCID: 2621417]
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35. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitors and lithium chloride. J. Surg. Res. 2010 Apr; 159(2):640-4.
[PubMed ID: 19394967, PMCID: 2858235]
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36. Pitt SC, Chen H. The phosphatidylinositol 3-kinase/akt signaling pathway in medullary thyroid cancer. Surgery 2008 Nov; 144(5):721-4.
[PubMed ID: 19081012, PMCID: 3245622]
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37. Zhang YW, Greenblatt DY, Repplinger D, Bargren A, Adler JT, Sippel RS, Chen H. Older age and larger tumor size predict malignancy in hürthle cell neoplasms of the thyroid. Ann. Surg. Oncol. 2008 Oct; 15(10):2842-6.
[PubMed ID: 18665423]
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38. Adler JT, Meyer-Rochow GY, Chen H, Benn DE, Robinson BG, Sippel RS, Sidhu SB. Pheochromocytoma: current approaches and future directions. Oncologist 2008 Jul; 13(7):779-93.
[PubMed ID: 18617683]
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39. Ning L, Jaskula-Sztul R, Kunnimalaiyaan M, Chen H. Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma. Ann. Surg. Oncol. 2008 Sep; 15(9):2600-5.
[PubMed ID: 18563491, PMCID: 2737668]
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40. Greenblatt DY, Cayo MA, Adler JT, Ning L, Haymart MR, Kunnimalaiyaan M, Chen H. Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells. Ann. Surg. 2008 Jun; 247(6):1036-40.
[PubMed ID: 18520232, PMCID: 2904809]
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41. Pinchot SN, Pitt SC, Sippel RS, Kunnimalaiyaan M, Chen H. Novel targets for the treatment and palliation of gastrointestinal neuroendocrine tumors. Curr Opin Investig Drugs 2008 Jun; 9(6):576-82.
[PubMed ID: 18516757, PMCID: 2905744]
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42. Deming D, Geiger P, Chen H, Vaccaro A, Kunnimalaiyaan M, Holen K. ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line. J. Gastrointest. Surg. 2008 May; 12(5):852-7.
[PubMed ID: 18299943]
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43. Platta CS, Greenblatt DY, Kunnimalaiyaan M, Chen H. Valproic acid induces Notch1 signaling in small cell lung cancer cells. J. Surg. Res. 2008 Jul; 148(1):31-7.
[PubMed ID: 18570928, PMCID: 2900385]
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44. Chen H. Therapeutic options for patients with metastatic gastrointestinal carcinoid. J Surg Oncol 2008 Mar 1; 97(3):203-4.
[PubMed ID: 18264978]
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45. Ning L, Greenblatt DY, Kunnimalaiyaan M, Chen H. Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells. Oncologist 2008 Feb; 13(2):98-104.
[PubMed ID: 18305053]
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46. Kunnimalaiyaan M, Ndiaye M, Chen H. Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways. Surgery 2007 Dec; 142(6):959-64; discussion 959-64.
[PubMed ID: 18063082, PMCID: 2180346]
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47. Greenblatt DY, Cayo M, Ning L, Jaskula-Sztul R, Haymart M, Kunnimalaiyaan M, Chen H. Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells. J. Gastrointest. Surg. 2007 Nov; 11(11):1515-20; discussion 1520.
[PubMed ID: 17874277]
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48. Greenblatt DY, Vaccaro AM, Jaskula-Sztul R, Ning L, Haymart M, Kunnimalaiyaan M, Chen H. Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells. Oncologist 2007 Aug; 12(8):942-51.
[PubMed ID: 17766653]
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49. Platta CS, Greenblatt DY, Kunnimalaiyaan M, Chen H. The HDAC inhibitor trichostatin A inhibits growth of small cell lung cancer cells. J. Surg. Res. 2007 Oct; 142(2):219-26.
[PubMed ID: 17612559]
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50. Kunnimalaiyaan M, Chen H. Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors. Oncologist 2007 May; 12(5):535-42.
[PubMed ID: 17522241]
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51. Greenblatt DY, Kunnimalaiyaan M, Chen H. Raf-1 activation in gastrointestinal carcinoid cells decreases tumor cell adhesion. Am. J. Surg. 2007 Mar; 193(3):331-5; discussion 335.
[PubMed ID: 17320529, PMCID: 1838566]
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52. Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H. Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells. Mol. Cancer Ther. 2007 Mar; 6(3):1151-8.
[PubMed ID: 17363508]
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53. Kappes A, Vaccaro A, Kunnimalaiyaan M, Chen H. Lithium ions: a novel treatment for pheochromocytomas and paragangliomas. Surgery 2007 Feb; 141(2):161-5; discussion 165.
[PubMed ID: 17263970, PMCID: 1945109]
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54. Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H. Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. J. Biol. Chem. 2006 Dec 29; 281(52):39819-30.
[PubMed ID: 17090547]
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55. Kunnimalaiyaan M, Ndiaye M, Chen H. Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. Surgery 2006 Dec; 140(6):1009-14; discussion 1014-5.
[PubMed ID: 17188151]
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56. Musunuru S, Chen H, Rajpal S, Stephani N, McDermott JC, Holen K, Rikkers LF, Weber SM. Metastatic neuroendocrine hepatic tumors: resection improves survival. Arch Surg 2006 Oct; 141(10):1000-4; discussion 1005.
[PubMed ID: 17043278]
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57. Vaccaro A, Chen H, Kunnimalaiyaan M. In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer. Anticancer Drugs 2006 Aug; 17(7):849-53.
[PubMed ID: 16926634]
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58. Sippel RS, Chen H. Carcinoid tumors. Surg. Oncol. Clin. N. Am. 2006 Jul; 15(3):463-78.
[PubMed ID: 16882492]
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59. Kappes A, Vaccaro A, Kunnimalaiyaan M, Chen H. ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells. J. Surg. Res. 2006 Jun 1; 133(1):42-5.
[PubMed ID: 16603190]
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60. Kunnimalaiyaan M, Chen H. The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors? Anticancer Drugs 2006 Feb; 17(2):139-42.
[PubMed ID: 16428931]
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61. Lal A, Chen H. Treatment of advanced carcinoid tumors. Curr Opin Oncol 2006 Jan; 18(1):9-15.
[PubMed ID: 16357558]
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62. Kunnimalaiyaan M, Yan S, Wong F, Zhang YW, Chen H. Hairy Enhancer of Split-1 (HES-1), a Notch1 effector, inhibits the growth of carcinoid tumor cells. Surgery 2005 Dec; 138(6):1137-42; discussion 1142.
[PubMed ID: 16360401]
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63. Kunnimalaiyaan M, Traeger K, Chen H. Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2005 Oct; 289(4):G636-42.
[PubMed ID: 16160079]
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64. Musunuru S, Carpenter JE, Sippel RS, Kunnimalaiyaan M, Chen H. A mouse model of carcinoid syndrome and heart disease. J. Surg. Res. 2005 Jun 1; 126(1):102-5.
[PubMed ID: 15916982]
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65. Van Gompel JJ, Kunnimalaiyaan M, Holen K, Chen H. ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells. Mol. Cancer Ther. 2005 Jun; 4(6):910-7.
[PubMed ID: 15956248]
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66. Chen H, Kunnimalaiyaan M, Van Gompel JJ. Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1. Thyroid 2005 Jun; 15(6):511-21.
[PubMed ID: 16029117]
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67. Nakakura EK, Sriuranpong VR, Kunnimalaiyaan M, Hsiao EC, Schuebel KE, Borges MW, Jin N, Collins BJ, Nelkin BD, Chen H, Ball DW. Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling. J. Clin. Endocrinol. Metab. 2005 Jul; 90(7):4350-6.
[PubMed ID: 15870121]
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68. Van Gompel JJ, Chen H. Insulin-like growth factor 1 signaling in human gastrointestinal carcinoid tumor cells. Surgery 2004 Dec; 136(6):1297-302.
[PubMed ID: 15657590]
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69. Mansour JC, Chen H. Pancreatic endocrine tumors. J. Surg. Res. 2004 Jul; 120(1):139-61.
[PubMed ID: 15172200]
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70. Van Gompel JJ, Sippel RS, Warner TF, Chen H. Gastrointestinal carcinoid tumors: factors that predict outcome. World J Surg 2004 Apr; 28(4):387-92.
[PubMed ID: 14994141]
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71. Sippel RS, Carpenter JE, Kunnimalaiyaan M, Chen H. The role of human achaete-scute homolog-1 in medullary thyroid cancer cells. Surgery 2003 Dec; 134(6):866-71; discussion 871-3.
[PubMed ID: 14668716]
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72. Sippel RS, Carpenter JE, Kunnimalaiyaan M, Lagerholm S, Chen H. Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2003 Aug; 285(2):G245-54.
[PubMed ID: 12851216]
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73. Sippel RS, Chen H. Activation of the ras/raf-1 signal transduction pathway in carcinoid tumor cells results in morphologic transdifferentiation. Surgery 2002 Dec; 132(6):1035-9; discussion 1039.
[PubMed ID: 12490852]
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74. Chen H, Biel MA, Borges MW, Thiagalingam A, Nelkin BD, Baylin SB, Ball DW. Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: transcriptional regulation by dual inhibitory regions. Cell Growth Differ. 1997 Jun; 8(6):677-86.
[PubMed ID: 9186001]
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75. Chen H, Thiagalingam A, Chopra H, Borges MW, Feder JN, Nelkin BD, Baylin SB, Ball DW. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc. Natl. Acad. Sci. U.S.A. 1997 May 13; 94(10):5355-60.
[PubMed ID: 9144241, PMCID: 24682]
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76. Borges M, Linnoila RI, van de Velde HJ, Chen H, Nelkin BD, Mabry M, Baylin SB, Ball DW. An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature 1997 Apr 24; 386(6627):852-5.
[PubMed ID: 9126746]
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77. Chen H, Carson-Walter EB, Baylin SB, Nelkin BD, Ball DW. Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1. Surgery 1996 Aug; 120(2):168-72; discussion 173.
[PubMed ID: 8751579]
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78. Chen H, Boyle TJ, Malim MH, Cullen BR, Lyerly HK. Derivation of a biologically contained replication system for human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. U.S.A. 1992 Aug 15; 89(16):7678-82.
[PubMed ID: 1502183, PMCID: 49774]
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