NIH, NIDCD, R01 DC014358 (Ciucci/Connor, Co-PI’s) 08/01/2015-07/31/2020
Influence of Neuromuscular Pathology on Parkinsonian Communication Deficits
The proposed research examines how muscles and nerves involved in communication and swallowing may be affected by Parkinson disease. Experiments will determine how pathologies in muscles and nerves contribute to communication and swallowing deficits and when in the disease process these deficits emerge. Further, this work will examine how exercise-based voice and swallow therapies prevent or reverse muscle and nerve pathologies using a novel genetic rat model.
Role: Co-Principal Investigator
NIH, NIDCD, R01 DC008149 (Connor, PI) 12/05/2006-06/30/2018
Lingual and Laryngeal Muscle Plasticity (Formerly, Aging, Exercise and Mechanisms of Altered Tongue Function)
The aims of this project are to quantify mechanisms of lingual and laryngeal muscle plasticity, microvascular geometry and red blood cell velocity with aging and exercise and to determine how aging and tongue exercise affect vocalization and deglutition behavior.
NIH, NIDCD, R33DC011130-03 (McCulloch, PI) 03/12/2013-02/28/2016
High Resolution Manometry: A Novel Pattern Recognition Method for Dysphagia
This study integrates high resolution pressure data and non-linear systems analysis to elucidate the salient features of normal and dysfunctional swallowing with the goal of immediate translation to clinical use.
NIH, NIDCD, 2R01DC005935-06 (Connor, PI) 06/01/2010-05/31/2015
Exercise as a Treatment for Tongue Weakness
The main hypothesis tested is that age-related alterations in tongue function are based upon naturally occurring denervation-reinnervation processes and that these processes can be reversed or prevented via electrical stimulation of the hypoglossal nerves to model exercise.
American Speech-Language-Hearing Association (Ciucci, PI) 11/30/2013/12/31/2014
Time Course and Pathology of Cranial Sensorimotor Deficits in Parkinson Disease
This grant tests the hypothesis that fine and cranial sensorimotor deficits emerge early in rats that have both homozygous knock-out of the DJ-11 gene that leads to early and progressive forms of Parkinson disease.
Role: Principal Investigator