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Publications

1. Zens TJ, Danobeitia JS, Chlebeck PJ, Zitur LJ, Odorico S, Brunner K, Coonen J, Capuano S, D'Alessandro AM, Matkowskyj K, Zhong W, Torrealba J, Fernandez L. Guidelines for the management of a brain death donor in the rhesus macaque: A translational transplant model. PLoS ONE 2017; 12(9):e0182552.
[PubMed ID: 28926566, PMCID: 5604963]
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2. Danobeitia JS, Ziemelis M, Ma X, Zitur LJ, Zens T, Chlebeck PJ, Van Amersfoort ES, Fernandez LA. Complement inhibition attenuates acute kidney injury after ischemia-reperfusion and limits progression to renal fibrosis in mice. PLoS ONE 2017; 12(8):e0183701.
[PubMed ID: 28832655, PMCID: 5568291]
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3. Ansari IH, Longacre MJ, Stoker SW, Kendrick MA, O'Neill LM, Zitur LJ, Fernandez LA, Ntambi JM, MacDonald MJ. Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion. Arch. Biochem. Biophys. 2017 Mar 15; 618():32-43.
[PubMed ID: 28193492, PMCID: 5445904]
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4. Scalea JR, Redfield RR, Arpali E, Leverson GE, Bennett RJ, Anderson ME, Kaufman DB, Fernandez LA, D'Alessandro AM, Foley DP, Mezrich JD. Does DCD Donor Time-to-Death Affect Recipient Outcomes? Implications of Time-to-Death at a High-Volume Center in the United States. Am. J. Transplant. 2017 Jan; 17(1):191-200.
[PubMed ID: 27375072]
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5. Scalea JR, D'Alessandro AM, Fernandez LA. Predicting Donor Death: Early Changes in Oxygen Saturation After Withdrawal of Support Predict Successful Donation During Donation After Circulatory Death. Transplant. Proc. 2016 Jul-Aug; 48(6):1887-92.
[PubMed ID: 27569916]
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6. Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ. Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity. Diabetes 2016 Sep; 65(9):2700-10.
[PubMed ID: 27284112, PMCID: 5001174]
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7. Vásquez-Montoya GA, Danobeitia JS, Fernández LA, Hernández-Ortiz JP. Computational immuno-biology for organ transplantation and regenerative medicine. Transplant Rev (Orlando) 2016 Oct; 30(4):235-46.
[PubMed ID: 27296889]
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8. Wang LJ, Kin T, O'Gorman D, Shapiro AMJ, Naziruddin B, Takita M, Levy MF, Posselt AM, Szot GL, Savari O, Barbaro B, McGarrigle J, Yeh CC, Oberholzer J, Lei J, Chen T, Lian M, Markmann JF, Alvarez A, Linetsky E, Ricordi C, Balamurugan AN, Loganathan G, Wilhelm JJ, Hering BJ, Bottino R, Trucco M, Liu C, Min Z, Li Y, Naji A, Fernandez LA, Ziemelis M, Danobeitia JS, Millis JM, Witkowski P. A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation. Cell Transplant 2016; 25(8):1515-1523.
[PubMed ID: 26922947, PMCID: 5167495]
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9. Yankol Y, Fernandez LA, Kanmaz T, Leverson GE, Mezrich JD, Foley D, Mecit N, D'Alessandro AM, Acarli K, Kalayoglu M. Results of pediatric living donor compared to deceased donor liver transplantation in the PELD/MELD era: Experience from two centers on two different continents. Pediatr Transplant 2016 Feb; 20(1):72-82.
[PubMed ID: 26861217]
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10. Scalea JR, Redfield RR, Rizzari MD, Bennett R, Anderson ME, Anderson JE, Kaufman DB, Sollinger HW, Fernandez LA, D'Alessandro AM, Mezrich J. When Do DCD Donors Die?: Outcomes and Implications of DCD at a High-volume, Single-center OPO in the United States. Ann. Surg. 2016 Feb; 263(2):211-6.
[PubMed ID: 26181480]
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11. Messenger SW, Thomas DD, Cooley MM, Jones EK, Falkowski MA, August BK, Fernandez LA, Gorelick FS, Groblewski GE. Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells. Cell Mol Gastroenterol Hepatol 2015 Nov 01; 1(6):695-709.
[PubMed ID: 26618189, PMCID: 4657148]
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12. Bannas P, Kramer H, Hernando D, Agni R, Cunningham AM, Mandal R, Motosugi U, Sharma SD, Munoz del Rio A, Fernandez L, Reeder SB. Quantitative magnetic resonance imaging of hepatic steatosis: Validation in ex vivo human livers. Hepatology 2015 Nov; 62(5):1444-55.
[PubMed ID: 26224591, PMCID: 4652324]
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13. Khoraki J, Katz MG, Funk LM, Greenberg JA, Fernandez LA, Campos GM. Feasibility and outcomes of laparoscopic sleeve gastrectomy after solid organ transplantation. Surg Obes Relat Dis 2016 Jan; 12(1):75-83.
[PubMed ID: 26048513]
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14. Danobeitia JS, Djamali A, Fernandez LA. The role of complement in the pathogenesis of renal ischemia-reperfusion injury and fibrosis. Fibrogenesis Tissue Repair 2014; 7():16.
[PubMed ID: 25383094, PMCID: 4224961]
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15. Danobeitia JS, Hanson MS, Chlebeck P, Park E, Sperger JM, Schwarznau A, Fernandez LA. Donor Pretreatment With IL-1 Receptor Antagonist Attenuates Inflammation and Improves Functional Potency in Islets From Brain-Dead Nonhuman Primates. Cell Transplant 2015; 24(9):1863-77.
[PubMed ID: 24759633]
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16. Brokhof MM, Sollinger HW, Hager DR, Muth BL, Pirsch JD, Fernandez LA, Bellingham JM, Mezrich JD, Foley DP, D'Alessandro AM, Odorico JS, Mohamed MA, Vidyasagar V, Ellis TM, Kaufman DB, Djamali A. Antithymocyte globulin is associated with a lower incidence of de novo donor-specific antibodies in moderately sensitized renal transplant recipients. Transplantation 2014 Mar 27; 97(6):612-7.
[PubMed ID: 24531846, PMCID: 4106033]
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17. Djamali A, Muth BL, Ellis TM, Mohamed M, Fernandez LA, Miller KM, Bellingham JM, Odorico JS, Mezrich JD, Pirsch JD, D'Alessandro TM, Vidyasagar V, Hofmann RM, Torrealba JR, Kaufman DB, Foley DP. Increased C4d in post-reperfusion biopsies and increased donor specific antibodies at one-week post transplant are risk factors for acute rejection in mild to moderately sensitized kidney transplant recipients. Kidney Int. 2013 Jun; 83(6):1185-92.
[PubMed ID: 23447068, PMCID: 3672254]
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18. LaMattina JC, Mezrich JD, Fernandez LA, D'Alessandro AM, Djamali A, Musat AI, Pirsch JD, Foley DP. Native kidney function following liver transplantation using calcineurin inhibitors: single-center analysis with 20 years of follow-up. Clin Transplant 2013 Mar-Apr; 27(2):193-202.
[PubMed ID: 23294013, PMCID: 3622762]
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19. Kaddis JS, Hanson MS, Cravens J, Qian D, Olack B, Antler M, Papas KK, Iglesias I, Barbaro B, Fernandez L, Powers AC, Niland JC. Standardized transportation of human islets: an islet cell resource center study of more than 2,000 shipments. Cell Transplant 2013; 22(7):1101-11.
[PubMed ID: 22889479, PMCID: 3745279]
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20. Barton FB, Rickels MR, Alejandro R, Hering BJ, Wease S, Naziruddin B, Oberholzer J, Odorico JS, Garfinkel MR, Levy M, Pattou F, Berney T, Secchi A, Messinger S, Senior PA, Maffi P, Posselt A, Stock PG, Kaufman DB, Luo X, Kandeel F, Cagliero E, Turgeon NA, Witkowski P, Naji A, O'Connell PJ, Greenbaum C, Kudva YC, Brayman KL, Aull MJ, Larsen C, Kay TW, Fernandez LA, Vantyghem MC, Bellin M, Shapiro AM. Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care 2012 Jul; 35(7):1436-45.
[PubMed ID: 22723582, PMCID: 3379615]
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21. LaMattina JC, Foley DP, Fernandez LA, Pirsch JD, Musat AI, D'Alessandro AM, Mezrich JD. Complications associated with liver transplantation in the obese recipient. Clin Transplant 2012 Nov-Dec; 26(6):910-8.
[PubMed ID: 22694047, PMCID: 3518672]
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22. Mezrich JD, Pirsch JD, Fernandez LA, Foley DP, Bellingham JM, Odorico JS, Leverson GE, Munoz-Del-Rio A, Sollinger HW, Kaufman DB, D'Alessandro AM. Differential outcomes of expanded-criteria donor renal allografts according to recipient age. Clin J Am Soc Nephrol 2012 Jul; 7(7):1163-71.
[PubMed ID: 22653256, PMCID: 3386667]
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23. Hirsch D, Odorico J, Danobeitia JS, Alejandro R, Rickels MR, Hanson M, Radke N, Baidal D, Hullett D, Naji A, Ricordi C, Kaufman D, Fernandez L. Early metabolic markers that anticipate loss of insulin independence in type 1 diabetic islet allograft recipients. Am. J. Transplant. 2012 May; 12(5):1275-89.
[PubMed ID: 22300172, PMCID: 4569145]
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24. Danobeitia JS, Fernandez LA. Clinical islet transplantation: recent advances in the field. Clin Transpl 2012; ():193-200.
[PubMed ID: 23721022]
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25. Danobeitia JS, Sperger JM, Hanson MS, Park EE, Chlebeck PJ, Roenneburg DA, Sears ML, Connor JX, Schwarznau A, Fernandez LA. Early activation of the inflammatory response in the liver of brain-dead non-human primates. J. Surg. Res. 2012 Aug; 176(2):639-48.
[PubMed ID: 22440934]
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26. Bellingham JM, Santhanakrishnan C, Neidlinger N, Wai P, Kim J, Niederhaus S, Leverson GE, Fernandez LA, Foley DP, Mezrich JD, Odorico JS, Love RB, De Oliveira N, Sollinger HW, D'Alessandro AM. Donation after cardiac death: a 29-year experience. Surgery 2011 Oct; 150(4):692-702.
[PubMed ID: 22000181, PMCID: 3357118]
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27. LaMattina JC, Mezrich JD, Fernandez LA, D'Alessandro AM, Bellingham JM, Musat AI, Foley DP. Simultaneous liver and kidney transplantation using donation after cardiac death donors: a brief report. Liver Transpl. 2011 May; 17(5):591-5.
[PubMed ID: 21506247, PMCID: 3088423]
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28. Foley DP, Fernandez LA, Leverson G, Anderson M, Mezrich J, Sollinger HW, D'Alessandro A. Biliary complications after liver transplantation from donation after cardiac death donors: an analysis of risk factors and long-term outcomes from a single center. Ann. Surg. 2011 Apr; 253(4):817-25.
[PubMed ID: 21475025, PMCID: 3103075]
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29. MacDonald MJ, Longacre MJ, Stoker SW, Kendrick M, Thonpho A, Brown LJ, Hasan NM, Jitrapakdee S, Fukao T, Hanson MS, Fernandez LA, Odorico J. Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets. J. Biol. Chem. 2011 May 27; 286(21):18383-96.
[PubMed ID: 21454710, PMCID: 3099655]
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30. Musat AI, Agni RM, Wai PY, Pirsch JD, Lorentzen DF, Powell A, Leverson GE, Bellingham JM, Fernandez LA, Foley DP, Mezrich JD, D'Alessandro AM, Lucey MR. The significance of donor-specific HLA antibodies in rejection and ductopenia development in ABO compatible liver transplantation. Am. J. Transplant. 2011 Mar; 11(3):500-10.
[PubMed ID: 21342448, PMCID: 3357120]
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31. Singh N, Djamali A, Lorentzen D, Pirsch JD, Leverson G, Neidlinger N, Voss B, Torrealba JR, Hofmann RM, Odorico J, Fernandez LA, Sollinger HW, Samaniego M. Pretransplant donor-specific antibodies detected by single-antigen bead flow cytometry are associated with inferior kidney transplant outcomes. Transplantation 2010 Nov 27; 90(10):1079-84.
[PubMed ID: 21293194]
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32. Hirsch D, Odorico J, Radke N, Hanson M, Danobeitia JS, Hullett D, Alejandro R, Ricordi C, Fernandez LA. Correction of insulin sensitivity and glucose disposal after pancreatic islet transplantation: preliminary results. Diabetes Obes Metab 2010 Nov; 12(11):994-1003.
[PubMed ID: 20880346]
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33. Davis DB, Lavine JA, Suhonen JI, Krautkramer KA, Rabaglia ME, Sperger JM, Fernandez LA, Yandell BS, Keller MP, Wang IM, Schadt EE, Attie AD. FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. Mol. Endocrinol. 2010 Sep; 24(9):1822-34.
[PubMed ID: 20660304, PMCID: 2940473]
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34. Hanson MS, Park EE, Sears ML, Greenwood KK, Danobeitia JS, Hullett DA, Fernandez LA. A simplified approach to human islet quality assessment. Transplantation 2010 May 27; 89(10):1178-88.
[PubMed ID: 20182409, PMCID: 2948961]
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35. Kaddis JS, Danobeitia JS, Niland JC, Stiller T, Fernandez LA. Multicenter analysis of novel and established variables associated with successful human islet isolation outcomes. Am. J. Transplant. 2010 Mar; 10(3):646-56.
[PubMed ID: 20055802, PMCID: 2860018]
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36. Kissler HJ, Niland JC, Olack B, Ricordi C, Hering BJ, Naji A, Kandeel F, Oberholzer J, Fernandez L, Contreras J, Stiller T, Sowinski J, Kaufman DB. Validation of methodologies for quantifying isolated human islets: an Islet Cell Resources study. Clin Transplant 2010 Mar-Apr; 24(2):236-42.
[PubMed ID: 19719726, PMCID: 3166241]
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37. Schwarznau A, Hanson MS, Sperger JM, Schram BR, Danobeitia JS, Greenwood KK, Vijayan A, Fernandez LA. IL-1beta receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis. J. Cell. Physiol. 2009 Aug; 220(2):341-7.
[PubMed ID: 19334038, PMCID: 2890273]
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38. Hanson MS, Steffen A, Danobeitia JS, Ludwig B, Fernandez LA. Flow Cytometric Quantification of Glucose-Stimulated β-Cell Metabolic Flux Can Reveal Impaired Islet Functional Potency. Cell Transplant 2008 Dec; 17(12):1337-1347.
[PubMed ID: 28876094]
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39. Chan MR, Thomas CP, Torrealba JR, Djamali A, Fernandez LA, Nishimura CJ, Smith RJ, Samaniego MD. Recurrent atypical hemolytic uremic syndrome associated with factor I mutation in a living related renal transplant recipient. Am. J. Kidney Dis. 2009 Feb; 53(2):321-6.
[PubMed ID: 18805611, PMCID: 2879708]
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40. Neidlinger NA, Odorico JS, Sollinger HW, Fernandez LA. Can 'extreme' pancreas donors expand the donor pool? Curr Opin Organ Transplant 2008 Feb; 13(1):67-71.
[PubMed ID: 18660709]
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41. Hanson MS, Steffen A, Danobeitia JS, Ludwig B, Fernandez LA. Flow cytometric quantification of glucose-stimulated beta-cell metabolic flux can reveal impaired islet functional potency. Cell Transplant 2008; 17(12):1337-47.
[PubMed ID: 19364071]
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42. Yagci G, Fernandez LA, Knechtle SJ, D'Alessandro AM, Chin LT, Musat AI, Lucey MR, Said A, Pirsch JD, Leverson G, Kalayoglu M. The impact of donor variables on the outcome of orthotopic liver transplantation for hepatitis C. Transplant. Proc. 2008 Jan-Feb; 40(1):219-23.
[PubMed ID: 18261591]
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43. D'Alessandro AM, Knechtle SJ, Chin LT, Fernandez LA, Yagci G, Leverson G, Kalayoglu M. Liver transplantation in pediatric patients: twenty years of experience at the University of Wisconsin. Pediatr Transplant 2007 Sep; 11(6):661-70.
[PubMed ID: 17663691]
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44. Couto FM, Minn AH, Pise-Masison CA, Radonovich M, Brady JN, Hanson M, Fernandez LA, Wang P, Kendziorski C, Shalev A. Exenatide blocks JAK1-STAT1 in pancreatic beta cells. Metab. Clin. Exp. 2007 Jul; 56(7):915-8.
[PubMed ID: 17570252]
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45. Sollinger HW, Becker YT, Burlingham W, D'Alessandro AM, Fernandez LA, Hullett D, Knechtle SJ, Odorico JS, O'Loughlin S, Pirsch JD, Rieselbach RE, Sundberg A, Voss B. The history of the University of Wisconsin transplant program. Clin Transpl 2007; ():271-87.
[PubMed ID: 18637475]
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46. Armann B, Hanson MS, Hatch E, Steffen A, Fernandez LA. Quantification of basal and stimulated ROS levels as predictors of islet potency and function. Am. J. Transplant. 2007 Jan; 7(1):38-47.
[PubMed ID: 17227556, PMCID: 2752033]
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47. Barth RN, Janus CA, Lillesand CA, Radke NA, Pirsch JD, Becker BN, Fernandez LA, Thomas Chin L, Becker YT, Odorico JS, D'Alessandro AM, Sollinger HW, Knechtle SJ. Outcomes at 3 years of a prospective pilot study of Campath-1H and sirolimus immunosuppression for renal transplantation. Transpl. Int. 2006 Nov; 19(11):885-92.
[PubMed ID: 17018123]
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48. Foley DP, Fernandez LA, Leverson G, Chin LT, Krieger N, Cooper JT, Shames BD, Becker YT, Odorico JS, Knechtle SJ, Sollinger HW, Kalayoglu M, D'Alessandro AM. Donation after cardiac death: the University of Wisconsin experience with liver transplantation. Ann. Surg. 2005 Nov; 242(5):724-31.
[PubMed ID: 16244547, PMCID: 1409855]
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49. Fernandez LA, Di Carlo A, Odorico JS, Leverson GE, Shames BD, Becker YT, Chin LT, Pirsch JD, Knechtle SJ, Foley DP, Sollinger HW, D'Alessandro AM. Simultaneous pancreas-kidney transplantation from donation after cardiac death: successful long-term outcomes. Ann. Surg. 2005 Nov; 242(5):716-23.
[PubMed ID: 16244546, PMCID: 1409854]
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50. Fernandez LA, Hatch EW, Armann B, Odorico JS, Hullett DA, Sollinger HW, Hanson MS. Validation of large particle flow cytometry for the analysis and sorting of intact pancreatic islets. Transplantation 2005 Sep 27; 80(6):729-37.
[PubMed ID: 16210958]
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51. Fernandez LA, Tsuchida M, Manthei E, Fechner JH, Oberley TD, Leverson GE, Knechtle SJ, Hamawy MM. Immune status assay (ISA): a noninvasive procedure for studying allograft rejection. Transpl. Immunol. 2004 Sep-Oct; 13(2):147-54.
[PubMed ID: 15380545]
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52. Di Carlo A, Odorico JS, Leverson GE, Fernandez LA, Chin LT, Becker YT, Knechtle SJ, Pirsch JD, D'Alessandro AM, Sollinger HW. Long-term outcomes in simultaneous pancreas-kidney transplantation: lessons relearned. Clin Transpl 2003; ():215-20.
[PubMed ID: 15387113]
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Published Abstracts


American Transplant Congress, 2005
American Journal of Transplantation, Supplement 11, Vol (5), 2005:

  • Abstract #1397 – Large Particle Flow Cytometry as a New Automated Method of Islet Yield Determination
  • Abstract #1398 – Rapid and Sensitive Assessment of Islet Viability by Multiparameter Flow Cytometry on Intact and Dissociated Islets.
  • Abstract #787 (2005) – Kinetic Flow Cytometry-Based Glucose Response Assays for the Assessment of Human Islet Cell Potency

World Transplant Congress, 2006
American Journal of Transplantation and Transplantation, Supplement 2006:

  • Abstract #1526 – Preliminary Assessment of the University of Wisconsin-Madison Islet Isolation and Transplantation Program
  • Abstract #2836 – Improving Clinical Outcomes of Islet Transplantation by Expanded Pre-transplant Quality Control Assessment
  • Abstract #2843 – Human Islets from Donation After Cardiac Death are Equivalent to Islets from Donation After Brain Death

International Xenotransplantation Association and International Pancreas and Islet Transplantation Association Joint Meeting, 2007
Xenotransplantation, Vol. 14(5), September 2007:

  • Abstract #108.5 – Preliminary Assessment of the University of Wisconsin-Madison Islet Isolation and Transplantation Program
  • Abstract #307.4 – Evaluation of Islet Quality from Donation After Cardiac Death Using a Novel Extended Quality Control Assessment Program
  • Abstract #307.1 – Quantitative and Qualitative Comparison of the Performance of Serva NB1 Collagenase & Neutral Protease with Liberase HI in the Isolation of Human Pancreatic Islets
  • Abstract #PJ1048 – Extended Quality Control Assessment of Human Islet isolation with Serva NB1 Collagenase & Neutral Protease – University of Wisconsin-Madison Experience

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