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Related Publications

Recent UW Thyroid Publications
  1. Chen H, Nicol TL, Udelsman R. Follicular lesions of the thyroid. Does frozen section evaluation alter operative management? Ann Surg. 1995; 222:101-106.
  2. Chen H, Carson-Walter EB, Baylin SB, Nelkin BD, Ball DW. Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1. Surgery. 1996; 120:168-173.
  3. Chen H, Zeiger MA, Clark DP, Westra WH, Udelsman R. Papillary carcinoma of the thyroid: can operative management be based solely on fine needle aspiration? J Am Coll Surg. 1997; 184:605-610.
  4. Saji M, Westra WH, Chen H, Umbricht C, Tuttle RM, Box MF, Udelsman R, Sukumar S, Zeiger MA. Telomerase activity in the differential diagnosis of papillary carcinoma of the thyroid. Surgery. 1997; 122:1137-1140.
  5. Chen H, Udelsman R. Papillary thyroid carcinoma: justification for total thyroidectomy and the management of lymph node metastases. Surg Oncol Clin N Am. 1998; 7:645-663.
  6. Chen H, Nicol TL, Zeiger MA, Dooley WC, Ladenson PW, Cooper DS, Ringel M, Parkerson S, Allo M, Udelsman R. Hurthle cell neoplasms of the thyroid: are there factors predictive of malignancy? Ann Surg. 1998; 227:542-546.
  7. Chen H, Roberts JR, Ball DW, Eisele DW, Baylin SB, Udelsman R, Bulkley GB. Effective long-term palliation of symptomatic, incurable metastatic medullary thyroid cancer by operative resection. Ann Surg. 1998; 227:887-895.
  8. Chen H, Nicol TL, Udelsman R. Clinically significant metastatic disease to the thyroid gland. World J Surg. 1999; 23:177-181.
  9. Cha C, Chen H, Westra WH, Udelsman R. Primary Thyroid Lymphoma: Can the Diagnosis Be Made Solely by Fine-Needle Aspiration? Annals of Surgical Oncology. 2002; 9:298-302.
  10. Sippel RS, Gauger PG, Angelos P, Thompson NW, Mack E, Chen H. Palliative Thyroidectomy for Malignant Lymphoma of the Thyroid. Annals of Surgical Oncology. 2002; 9:907-911.
  11. Chen H, Dudley NE, Westra WH, Sadler GP, Udelsman R. The Utilization of Fine-Needle Aspiration in Patients Undergoing Thyroidectomy at Two Academic Centers Across the Atlantic. World J Surg. 2003; 27:208-211.
  12. Sippel RS, Carpenter JE, Kunnimalaiyaan M, Chen H. The Role of Human Achaete-Scute Homolog-1 in Medullary Thyroid Cancer Cells. Surgery. 2003; 134:866-73.
  13. Callcut R, Selvaggi SM, Mack E, Ozgul O, Warner TF, Chen H. The Utility of Frozen Section Evaluation for Follicular Thyroid Lesions. Annals of Surgical Oncology. 2004; 11:94-98.
  14. Chen H, Udelsman R. Hurthle cell adenoma and carcinoma. In: Clark OH, Duh QY, eds. Textbook of Endocrine Surgery. Philadelphia, PA: W.B. Saunders Company; 1997.
  15. Chen H, Nicol TL, Rosenthal DL, Udelsman R. The role of fine needle aspiration in the evaluation of thyroid nodules. In: Norton JA, ed. Problems in General Surgery: Surgery of the Thyroid Gland. New York, NY: Lippincott-Raven Publishers; 1997.
  16. Udelsman R, Chen H. The current management of thyroid cancer. In: Cameron JL, ed. Advances in Surgery. St. Louis, Mo: Mosby, Inc.; 1999; No. 33.
  17. Chen H, Udelsman R. Follicular, Hurthle Cell, and Anaplastic Thyroid Cancer. In: Bland KI, ed. The Practice of General Surgery. Philadelphia, PA: W.B. Saunders Co., 2001.
  18. Chen H, Udelsman R. Hurthle cell adenoma and carcinoma. In: Clark OH, Duh QY, eds. Textbook of Endocrine Surgery 2nd ed. Philadelphia, PA: W.B. Saunders Company, 2005; 123-128.
  19. Sippel RS, Chen H. Multiple Endocrine Neoplasia. In: Goldin SB, Zervos EE, eds. Pocket Surgical Oncology. Philadelphia, PA: PocketMedicine.com, Inc. 2003.
  20. Sippel RS, Chen H. Reoperative Endocrine Surgery. In: Callery M, ed. Handbook of Reoperative General Surgery. Maiden, MA: Blackwell Publishing, Inc., 2006; 135-150.
  21. Sippel RS, Chen H. Thyroid and Parathyroid Disorders. In: Makary M, ed. General Surgery Review. New York, NY: Springer, 2004; 9-22.
  22. Sippel RD, Chen H. Thyroid Lymphoma and other Metastatic Lesions. In: Oertli D, Udelsman R, eds. Surgery of the Thyroid and Parathyroid Glands. Heidelberg, Germany: Springer-Verlag. 2007; 171-177.
  23. Chen H, Kunnimalaiyaan M, Van Gompel JJ. Medullary Thyroid Cancer: the functions of raf-1 and human achaete-scute homolog-1. Thyroid. 2005; 15(6):515-525.
  24. Greenblatt DY, Woltman T, Harter J, Starling J, Mack E, Chen H. Fine-Needle Aspiration Optimizes Surgical Management in Patients with Thryoid Cancer. Annals of Surgical Oncology. 2006; 31:9-12.
  25. Chen H. Fine Needle Aspiration of the Thyroid. In: Moley JF, ed. Surgery of the Thyroid Gland. American College of Surgeons postgraduate course syllabus, 2005; 21-23.
  26. Schussler-Fiorenza C, Bruns C, Chen H. The Surgical Management of Graves' Disease. Journal of Surgical Research. 2006; 133:207-214.
  27. Cheema Y, Olson S, Elson D, Chen H. What is the Biology and Optimal Treatment for Papillary Microcarcinoma of the Thyroid. Journal of Surgical Research. 2006; 134:160-162.
  28. Sippel RS, Ozgul O, Hartig GK, Mack E, Chen H. The Risk and Consequences of Incidental Parathyroidectomy during Thyroid Resection. ANZ Journal of Surgery. 2007; 77:33-36.
  29. Cheema Y, Repplinger D, Elson D, Chen H. Is Tumor Size the Best Predictor of Outcome for Papillary Thyroid Cancer. Annals of Surgical Oncology. 2006; 13:1524-1528.
  30. Greenblatt DY, Chen H. Palliation of Advanced Thyroid Malignancies. Surgical Oncology. 2007; 16:237-247.
  31. Greenblatt DY, Elson D, Mack E, Chen H. Initial Lymph Node Dissection Increases Cure Rates in Patients with Medullary Thyroid Cancer. Asian Journal of Surgery. 2007; 30:108-112.
  32. Olson S, Cheema Y, Harter J, Starling J, Chen H. Does Frozen Section Alter Surgical Management of Multinodular Thyroid Disease? Journal of Surgical Research. 2006; 136:179-181.
  33. Chen H. Voice Changes after Thyroid Surgery: How Often Do They Occur and Can They Be Prevented? Contemporary Surgery. 2006; 62:410-413.
  34. Sippel RS, Chen H. Thyroid and Parathyroid Disorders. In: Makary M, ed. General Surgery Review, 2nd ed.. Washington DC: Lander-Drysfale. 2008; 165-180.
  35. Kunnimalaiyaan M, Ndiaye M, Chen H. Apoptosis mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. Surgery. 2006; 140:1009-1015.
  36. Kunnimalayaan M, Vaccaro AM, Ndiaye MA, Chen H. Overexpression of the Notch1 Intracellular Domain (NICD) inhibs cellular proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. Journal of Biological Chemistry. 2006; 281:39819-39830.
  37. Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H. Inactivation of glycogen synthase kinase-3, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cell. Molecular Cancer Therapeutics. 2007; 6:1151-1158.
  38. Kunnimalaiyaan M, Haymart MR. Chen H. Tumor Suppressor Role of Notch1 and Raf-1 Signaling in Medullary Thyroid Cancer Cells. Translational Oncogenomics. 2007; 2:43-47.
  39. Olson S. Starling JR, Chen H. Symptomatic Benign Multinodular Goiter: Unilateral or Bilateral Thyroidectomy? Surgery. 2007; 142:458-462.
  40. Repplinger D, Bargren A, Zhang Y, Adler JT, Haymart M, Chen H. Is Hashimoto's thyroiditis a risk factor for papillary thyroid cancer? Journal of Surgical Research. 2008; 150: 49-52.
  41. Chen H. Pre-operative management of patients with Graves' disease. Surgery. 2008; 143:292-293.
  42. Haymart MR, Greenblatt DY, Elson DF, Chen H. The Role of Intraoperative Frozen Section if Suspicious for Papillary Thyroid Cancer. Thyroid. 2008; 18:419-423.
  43. Haymart MR, Repplinger DJ, Leverson GE, Elson DF, Sippel RS, Jaume JC, Chen H. Higher Serum TSH Level in Thyroid Nodule Patients is Associated with Greater Risks of Differentiated Thyroid Cancer and Advanced Tumor Stage. Journal of Clinical Endocrinology and Metabolism. 2008; 93:809-814.
  44. Greenblatt DY, Cayo M, Adler JT, Ning L, Haymart M, Kunnimalaiyaan M, Chen H. Valproic Acid Activates Notch1 Signaling and Induces Apoptosis in Medullary Thyroid Cancer Cells. Ann Surg. 2008; 247:1036-1040.
  45. Sippel RS, Kunnimalaiyaan M, Chen H. Current Management of Medullary Thyroid Cancer.  The Oncologist. 2008; 13:539-547.
  46. Ning L, Jaskula-Sztul R, Kunnimalaiyaan M, Chen H. Suberoyl bishydroxamic acid activates Notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma.  Annals of Surgical Oncology. 2008; 15:2600-2605.
  47. Ning L, Kunnimalaiyaan M, Chen H. Regulation of cell-cell contact molecules and the metastatic phenotype of medullary thyroid carcinoma by the Raf-1/MEK/ERK pathway. Surgery. 2008; 144:920-925.
  48. Pinchot SN, Chen H, Sippel RS. Incisions and Exposure of the Neck for Thyroidectomy and Parathyroidectomy. Operative Techniques in General Surgery. 2008; 10:63-76.
  49. Sippel RS, and Chen H. Medullary Thyroid Cancer. In: Loh, and Inabnet, eds. Endocrine Surgery. New York, NY:Springer. 2009; 149-162.
  50. Pinchot SN, Sippel RS, Chen H. Multi-targeted approach in the treatment of thyroid cancer. Therapeutics and Clinical Risk Management. 2008; 4:1-13.
  51. Musunuru S, Schaefer S, Chen H.  The Use of the Ligasure for Hemostasis During Thyroid Lobectomy. Am. J. Surg. 2008; 195:382-385.
  52. Ning L, Greenblatt DY, Kunnimalaiyaan M, Chen H. Suberoyl Bis-Hydroxamic Acid Activates Notch1 Signaling and Induces Apoptosis in Medullary Thyroid Carcinoma Cells. The Oncologist 2008; 13:98-104.
  53. Zhang Y, Greenblatt DY, Repplinger DJ, Bargren A, Adler JT, Sippel RS, Chen H. Older Age and Larger Tumor Size Predict Malignancy in Hürthle Cell Neoplasms of the Thyroid. Annals of Surgical Oncology. 2008; 15:2842-2846.
  54. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitors and lithium chloride. Journal of Surgical Research 2010; 159:640-644.
  55. Adler JT, Chen H. Preserving function and quality of life after thyroid and parathyroid surgery. Lancet Oncology. 2008; 9:1069-1075.
  56. Pitt SC, Sippel RS, Chen H. Contralateral papillary thyroid cancer: Does size matter? Am. J. Surg. 2009; 197:342-347.
  57. Greenblatt DY, Sippel RS, Leverson G, Frydman J, Schaefer S, Chen H.  Thyroid Resection Improves Perception of Swallowing Function in Patients with Thyroid Disease. World Journal of Surgery. 2009; 33:255-260.
  58. Haymart MR, Glinberg SL, Liu JL, Sippel RS, Jaume JC, Chen H. Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extension. Clinical Endocrinology. 2009; 71:434-439.
  59. Haymart MR, Cayo MA, Chen H. Thyroid Hormone Replacement in Women: Is Surgeon Knowledge Related to Operative Volume? Thyroid. 2010; 20:627-631.
  60. Pitt SC, Chen H. The phosphatidylinositol 3-kinase/akt signaling pathway in medullary thyroid cancer. Surgery 2008; 144:721-724.
  61. Chen H. Laryngeal morbidity following thyroidectomy: Is it always the surgeon-Invited Critique. Archives of Surgery. 2009; 144:153.
  62. Xiao X, Ning L, Chen H. Notch1 Mediates Growth Suppression of Papillary and Follicular Thyroid Cancer Cells by HDAC Inhibitors. Molecular Cancer Therapeutics. 2009; 8: 350-356.
  63. Pinchot SN, Al-Wagih H, Schaefer S, Sippel RS, Chen H. Accuracy of fine needle aspiration biopsy for predicting neoplasm or carcinoma in thyroid nodules > 4cm. Archives of Surgery. 2009; 914-920.
  64. Adler JT, Cook M, Luo Y, Pitt SC, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of GSK-3ß. Molecular Cancer Therapeutics. 2009; 8:914-920.
  65. Pinchot SN, Sippel RS, Chen H. Multi-targeted approach in the treatment of thyroid cancer. Therapeutics and Clinical Risk Management. 2008; 4:1-13.
  66. Bargren AE Meyer-Rochow GY, Delbridge LW, Sidhu SB, Chen H. Outcomes of surgically managed pediatric thyroid cancer. Journal of Surgical Research. 2009; 156:70-73.
  67. Stoll SJ, Pitt SC, Liu J, Schaefer S, Sippel RS, Chen H. Thyroid hormone replacement after thyroid lobectomy. Surgery. 2009; 146:554-558.
  68. Stoll SJ, Pitt SC, Chen H. Follicular Thyroid Cancer Growth Inhibition by Proteosome Inhibitor MG132. Journal of Surgical Research. 2009; 156:39-44.
  69. Haymart MR, Cayo MA, Chen H. Papillary Thyroid Microcarcinomas: Big Decisions for a Small Tumor. Annals of Surgical Oncology . 2009; 16:2936-2942.
  70. Cook MR, Luo J, Ndiaye M, Chen H, Kunnimalaiyaan M. Xanthohumol Inhibits the Neuroendocrine Transcription Factor Achaete-Scute Complex-Like 1, Suppresses Proliferation and Induces Phosphorylated ERK1/2 in Medullary Thyroid Cancer. Am. J. Surg. 2010; 199:315-318.
  71. Schiro AJ, Pinchot SN, Chen H, Sippel RS. Clinical Efficacy of Fine-Needle Aspiration Biopsy of Thyroid Nodules in Males. Journal of Surgical Research. 2010; 159:1127-30.
  72. Sippel RS, Elaraj DM, Poder L, Duh QY, Kebebew E, Clark OH. Localization of recurrent thyroid cancer using intraoperative ultrasound-guided dye injection. World J Surg. 2009 Mar; 33(3):434-9.
  73. Sippel RS, Elaraj DM, Khanafshar E, Zarnegar R, Kebebew E, Duh QY, Clark OH. Tumor size predicts malignant potential in Hürthle cell neoplasms of the thyroid. World J Surg. 2008 May; 32(5):702-7.
  74. Sippel RS, Elaraj DM, Khanafshar E, Kebebew E, Duh QY, Clark OH. Does the presence of additional thyroid nodules on ultrasound alter the risk of malignancy in patients with a follicular neoplasm of the thyroid? Surgery. 2007 Dec; 142(6):851-7; discussion 857.e1-2. Epub 2007 Oct 26. Erratum in: Surgery. 2008 Feb; 143(2):302.
  75. Sippel RS, Caron NR, Clark OH. An evidence-based approach to familial nonmedullary thyroid cancer: screening, clinical management, and follow-up. World J Surg. 2007 May; 31(5):924-33. Review.
  76. Sippel RS, Chen H. Controversies in the surgical management of newly diagnosed and recurrent/residual thyroid cancer. Thyroid. 2009; 19:1373-1380.
  77. Cook MR, Yu XM, Chen H. Notch in the Development of Thyroid C-cells and the Treatment of Medullary Thyroid Cancer. Am J Transl Res. 2010; 2: 119–125. PMCID: PMC2826828
  78. Ning L, Chen H, Sippel RS. Thyroid Cancer. In: Harari PM, Connor NP, Grau C, eds. Functional Preservation and Quality of Life in Head and Neck Radiotherapy. Berlin, Germany: Springer-Verlag. 2009; pp117-124.
  79. Pinchot SN, Kunnimalaiyaan M, Sippel RS, Chen H. Medullary Thyroid Carcinoma: Targeted Therapies and Future Directions. Journal of Oncology. Vol. 2009; Article ID 183031; doi:10.1155/2009/183031.
  80. Youngwirth L, Benavidez J, Sippel RS, Chen H. Parathyroid Hormone Deficiency after Total Thyroidectomy: Incidence and Time to Resolution. Journal of Surgical Research. 2010; 163:69-71.
  81. Youngwirth L, Benavidez J, Sippel RS, Chen H. Post-Operative Parathyroid Hormone Testing Reduces Symptomatic Hypocalcemia and Associated Emergency Room Visits after Total Thyroidectomy. Surgery. 2010; 148:841-846.
  82. Bargren AE, Meyer-Rochow GY, Sywak MS, Delbridge LW, Chen H, Sidhu SB. Diagnostic Utility of Fine-Needle Aspiration Cytology in Pediatric Differentiated Thyroid Cancer. World J Surg. 2010; 34:1254-1260.
  83. Zarebczan B, Chen H. Multi-targeted approach in the treatment of thyroid cancer. Minerva Chir. 2010;65(1):59-69. PMCID:PMC2901507
  84. Chen H, Sippel RS, O’Dorisio MS, Vinik AI, Lloyd RV, Pacak K. The NANETS Consensus Guideline for the Diagnosis and Management of Neuroendocrine Tumors: Pheochromocytoma, Paraganglioma, and Medullary Thyroid Cancer. Pancreas. 2010; 39:775-783.
  85. Zarebczan B, Rajamanickam V, Leverson G, Chen H, Sippel RS. Training our Future Endocrine Surgeons: A Look at the Endocrine Surgery Operative Experience of U.S. Surgical Residents. Surgery. 2010; 148:1075-1081.
  86. Roy M, Rajamanickam V, Chen H, Sippel RS. Is DVT Prophylaxis Necessary for Thyroidectomy and Parathyroidectomy? Surgery. 2010; 148:1163-1169.
  87. Zarebczan B, Mohanty D, Chen H. A Comparison of the LigaSure and Harmonic Scalpel in Thyroid Surgery: A Single Institution Review. Annals of Surgical Oncology. 2011; 18:214-218.
  88. Sippel RS, Chen H. Thyroid Lymphoma and Other Metastatic Lesions. In: Oertli D, Udelsman R, eds. Surgery of the Thyroid and Parathyroid Glands, 2nd ed. Heidelberg, Germany: Springer-Verlag. 2011; 74-77.
  89. Truong M, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H. Resveratrol Induces Notch2-mediated Apoptosis and Suppression of Neuroendocrine Markers in Medullary Thyroid Cancer. Annals of Surgical Oncology. 2011; 18:1506-1511. NIHMS249400
  90. Liu J, Bargren A, Schaefer S, Chen H, and Sippel RS. Total thyroidectomy: a safe and effective treatment for Graves’Disease. Journal of Surgical Research. 2011; 168:1-4.
  91. McManus C, Luo J, Sippel RS, Chen H. Should Patients with Symptomatic Hashimoto’s Thyroiditis Pursue Surgery? Journal of Surgical Research. 2011; 170:52-55.
  92. Jaume J, Chen H. Inadequate Cytology of Thyroid Nodules. Repeat it or Live With it. Annals of Surgical Oncology. 2011; 18:1222-1223.
  93. Coorough N, Hudak K, Buehler D, Selvaggi S, Sippel RS, Chen H. Fine Needle Aspiration of the Thyroid: a Contemporary Experience of 3,981 Cases. Journal of Surgical Research. 2011; 170:48-51.
  94. Smith CT, Zarebczan B, Alhefdhi A, Chen H. Infrared Thermographic Profiles Of Vessel Sealing Devices On Thyroid Parenchyma. Journal of Surgical Research. 2011; 170:64-68.
  95. Jaskula-Sztul R, Pisarnturakit P, Landowski M, Chen H, Kunnimalaiyaan M. Expression of the active Notch1 decreases MTC tumor growth in vivo. Journal of Surgical Research. 2011; 171:23-27.
  96. Phan T, Yu X, Kunnimalaiyaan M, Chen H. Antiproliferative Effect of Chrysin on Anaplastic Thyroid Cancer. Journal of Surgical Research. 2011; 170:84-88.
  97. Yu X, Wan Y, Sippel RS, Chen H. Should All Papillary Thyroid Microcarcinomas Be Aggressively Treated? An Analysis of 18,445 Cases. Annals of Surgery. 2011; 254:653-660.
  98. Mazeh H, Chen H. Advances in surgical therapy of thyroid cancer. Nature Reviews Endocrinology. 2011; 7:581-588.
  99. Mazeh H, Benavidez J, Poehls JL, Youngwirth L, Chen H, Sippel, RS. A Family History of Non-medullary Thyroid Cancer in One First Degree Relative is Associated with More Aggressive Disease. Thyroid. 2012; 22:3-8.
  100. Hudak K, Mazeh H, Sippel RS, Chen H. Hurthle Cell metaplasia on fine needle aspiration biopsy is not by itself an indication for thyroid surgery. Am. J. Surg. 2012; 203:287-291.
  101. Yu X, Patel P, Chen H, Sippel RS. False-negative Fine Needle Aspiration of Thyroid Nodules Cannot be Attributed to Sampling Error Alone. Am. J. Surg. 2012; 203:331-334.
  102. Luo J, McManus C, Chen H, Sippel RS. Are there predictors of malignancy in patients with multinodular goiter? Journal of Surgical Research. 2012; 174:207-210.
  103. Mazeh H, Chen H. Outpatient thyroidectomy – methods to predict hypocalcemia. What’s New in ACS Surgery. April 2011.
  104. Poehls JL, Chen H, Sippel RS Pre-operative Ultrasound Findings Predict the Need for Repeat Surgery in Papillary Thyroid Cancer. Endocrine Practice. 2012; 19:2958-2962.
  105. Chen H. Fine Needle Aspiration Biopsy of the Thyroid: Thyroid Lobectomy and Subtotal and Total Thyroidectomy. In Fischer J, Jones D, Pomposelli F, Upchurch G, Limberg S, Schwaitzber S, Bland K, eds. Mastery of Surgery, 6th Edition. 2012; pp 468-478.
  106. Schneider D, Chen H. Doctor, My Thyroid is Choking Me. Archives of Surgery. 2012; 147:626.
  107. Reiher AE, Mazeh H, Schaefer S, Chen H, Sippel RS. Thyroidectomy decreases snoring and sleep apnea symptoms. Thyroid. 2012; 11:1160-1164.
  108. Mazeh H, Khan Q, Schneider DF, Schaefer S, Sippel RS, Chen H. Same day thyroidectomy program: Eligibility and safety evaluation. Surgery. 2012; 6:1133-1141.
  109. Yu X, Phan T, Patel PN, Jaskula-Sztul R, Chen H. Chrysin Activates Notch1 Signaling and Suppresses Tumor Growth of Anaplastic Thyroid Carcinoma In vitro and In vivo. Cancer. 2013; 119:774-781. NIHMSID#388207
  110. Burke JB, Sippel RS, Chen H. Evolution of Pediatric Thyroid Surgery at a Tertiary Medical Center. Journal of Surgical Research. 2012; 177:268-274.
  111. Hong BW, Mazeh H, Chen H, Sippel RS. Routine chest x-ray prior to thyroid surgery – is it always necessary? World J Surg. 2012; 36:2584-2589.
  112. Buehler D, Hardin H, Shan W, Montemayor-Garcia C, Rush P, Asioli S, Chen H, Lloyd RV. Expression of Epithelial-Mesenchymal Transition Regulators SNAI2 and TWIST1 in Thyroid Carcinomas. Modern Pathology. 2013; 26:54-61.
  113. Chen H. Fine Needle Aspiration Biopsy of the Thyroid: Thyroid Lobectomy and Subtotal and Total Thyroidectomy. In: Fischer J, Jones D, Pomposelli F, Upchurch G, Limberg S, Schwaitzber S, Bland K, eds. Mastery of Surgery, 6th edition. 2012; 468-478.
  114. Zarebczan B, Chen H. Medullary Thyroid Cancer. In: Dimick JB, Upchurch Jr. GR, Sonnenday, CJ. Clinical Scenarios in Surgery: Decision Making and Operative Technique. Philadelphia, PA: Lippincott Williams & Wilkins. 2012; 293-296.
  115. Yu X, Lloyd R, Chen H. Current Treatment of Papillary Thyroid Microcarcinoma. Advances in Surgery. 2012; 46:192-203.
  116. McManus C, Liu J, Sippel, Chen H. Is Thyroidectomy in Patients with Hashimoto's Thyroiditis More Risky? Journal of Surgical Research. 2012; 178:529-532.
  117. Schneider DF, Mazeh H, Chen H, Sippel RS. Lymph node ratio predicts recurrence in papillary thyroid cancer. The Oncologist. 2013; 18:157-162.
  118. Shepet K, Alhefdhi A, Lai N, Mazeh H, Sippel RS, Chen H. Hereditary Medullary Thyroid Cancer: Age-Appropriate Thyroidectomy Improves Disease-Free Survival. Annals of Surgical Oncology. 2012; 172:195-198.
  119. Schneider DF, Chen H, Sippel RS. The Impact of Lymph Node Ratio on Survival in Papillary Thyroid Cancer. Annals of Surgical Oncology (in press).
  120. Ojomo KA, Schneider DF, Reiher AE, Lai N, Schaefer S, Chen H, Sippel RS. Using BMI to Predict Optimal Thyroid Dosing Following Thyroidectomy. Journal of the American College of Surgeons. 2013; 216:454-460.
  121. Alhefdhi A, Mazeh H. Chen H. Role of Post-operative Vitamin D and/or Calcium Routine Supplementation in Preventing Hypocalcemia Post-thyroidectomy-Meta-analysis Review. The Oncologist. 2013; 18:533-542.
  122. Coorough N, Hudak K, Jaume JC, Buehler D, Selvaggi S, Rivas J, Sippel RS, Chen H. Non-Diagnostic Fine Needle Aspirations of the Thyroid: Is the Risk of Malignancy Higher? Journal of Surgical Research. 2013; 184:746-750. PMID:23490138
  123. Murray SE, Schneider DF, Bauer PS, Sippel RS, Chen H. Synchronous and Antecedent Non-Thyroidal Malignancies in Patients with Papillary Thyroid Carcinoma. Journal of the American College of Surgeons. 2013; 216:1174-1180. NIHMSID#446805
  124. Yu X, Schneider DF, Leverson G, Yan Y, Chen H, Sippel RS. Follicular Variant of Papillary Thyroid Carcinoma is a Unique Clinical Entity: A Population-Based Study of 10,740 Cases. Thyroid. 2013; 10:1263-1268.
  125. Panneerselvan R, Schneider DF, Sippel RS, Chen H. Radioactive iodine scanning is not beneficial but its use persists for euthyroid patients. Journal of Surgical Research. 2013; 184:269-273.
  126. Bessey L, Lai N, Coorough N, Chen H, Sippel RS. The incidence of thyroid cancer by FNA varies by age and gender. Journal of Surgical Research. 2013; 184:761-765.
  127. Yu X, Jaskula-Sztul R, Ahmed K, Harrison AD, Kunnimalaiyaan M, Chen H. Resveratrol Induces Differentiation Markers Expression in Anaplastic Thyroid Carcinoma via Activation of Notch1 Signaling and Suppresses Cell Growth. Molecular Cancer Therapeutics. 2013; 12:1276-1287.
  128. Vrabec S, Clark N, Oltmann SC, Chen H, Sippel RS. A Short-Stay Unit for Thyroidectomy Patients Increases Discharge Efficiency. Journal of Surgical Research. 2013; 184:204-208.
  129. Bauer PS, Murray SE, Clark N, Pontes DS, Sippel RS, Chen H. Unilateral thyroidectomy for the treatment of benign multinodular goiter. Journal of Surgical Research. 2013; 184:514-518.
  130. Schneider DF, Chen H. New Developments in the Treatment of Thyroid Cancer. CA: A Cancer Journal for Clinicians. 2013; 63:373-994. NIHMSID #474096
  131. Alhefdhi A, Burke JF, Redlich A, Kunnimalaiyaan M, Chen H. Leflunomide Supresses Growth in Human Medullary Thyroid Cancer Cells. Journal of Surgical Research. 2013; 185:212-216. NIHMSID#487868
  132. Burke JF, Schlosser L, Harrison AD, Kunnimalaiyaan M, Chen H. MK-2206 Causes Growth Suppression and Reduces Neuroendocrine Tumor Marker Production in Medullary Thyroid Cancer through Akt Inhibition. Annals of Surgical Oncology. 2013; 20:3862-3868.
  133. Roy M, Chen H, Sippel RS. Current Understanding and Management of Medullary Thyroid Cancer. The Oncologist. 2013; 18:1093-1100.
  134. Xu W, Burke JF, Pillaa S, Chen H, Jaskula-Sztul R, Gong S. Octreotide-functionalized and resveratrol-loaded unimolecular micelles for targeted neuroendocrine cancer therapy. Nanoscale. 2013; 5:9924-9933.
  135. Tesfazghi S, Eide J, Dammalapati A; Korlesky C, Wyche T, Bugni T, Chen H, Jaskula-Sztul R. Thiocoraline Alters Neuroendocrine Phenotype and Activates the Notch Pathway in MTC-TT Cell Line. Cancer Medicine. 2013.
  136. Pozo K, Castro-Rivera E, Tan C, Plattner F, Schwach G, Siegl V, Meyer D, Guo A, Gundara J, Mettlach G, Richer E, Guevara LA, Ning L, Tsai L, Antich P, Sidhu S, Robinson BG, Chen H, Nwariaku FE, Pfragner R, Richardson JA, Bibb JA. The Role of Cdk5 in Neuroendocrine Thyroid Cancer. Cancer Cell. 2013; 24:499-511.
  137. Carter Y, Sippel RS, Chen H. Hypothyroidism in Cancer Patients. The Oncologist. 2014; 19:34-43.
  138. Sippel RS, Chen H. Thyroid and Parathyroid. In: Makary M, ed. General Surgery Review, 3rd ed. Baltimore, MD: Wolter Kluwer Health. 2014; pp 209-224.
  139. Carter Y, Chen H, Sippel RS. An iPTH based protocol for the prevention and treatment of symptomatic hypocalcemia after thyroidectomy. Journal of Surgical Research 2014; 186: 23-28. NIHMSID#526886.
  140. Coorough NE, Schneider DF, Woll ML, Sippel RS, Chen H, Schwarze ML, Mazeh H. A Survey of Preferences Regarding Surgical Approach to Thyroid Surgery. World J Surg. 2014; 38:696-703.
  141. Patel PN, Yu X, Jaskula-Sztul R, Chen H. Hesperetin Activates the Notch1 Signaling Cascade, Causes Apoptosis, and Induces Cellular Differentiation in Anaplastic Thyroid Cancer. Annals of Surgical Oncology (in press).
  142. Oltmann SC, Schneider DF, Sivashanmugam T, Chen H, Sippel RS. Radioactive iodine remnant uptake after completion thyroidectomy – Not such a complete cancer operation. Annals of Surgical Oncology. 2014; 21:1379-1383. NIHMSID#555709
  143. Oltmann SC, Schneider DF, Chen H, Sippel RS. Markedly elevated thyroglobulin levels in the pre-operative thyroidectomy patient correlates with metastatic burden. Journal of Surgical Research. 2014; 187:1-5.
  144. Schneider DF, Mazeh H, Lubner S, Jaume JC, Chen H. Cancer of the Endocrine System. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE eds. Abeloff’s Clinical Oncology. Philadelphia, PA: Elsevier 2014. pp 1112-1142.
  145. Schneider DF, Nookala R, Jaraczewski TJ, Chen H, Solorzano CC, Sippel RS. Thyroidectomy as Primary Treatment Optimizes BMI in Patients with Hyperthyroidism. Annals of Surgical Oncology. 2014; 21: 2303-2309.
  146. Schneider DF, Mazeh H, Oltmann SC, Chen H, Sippel RS. A Novel Thyroidectomy Difficulty Scale Correlates with Operative Times. World J Surg. 2014; 38:1984-1989.
  147. Weinlander E, Somnay Y, Harrison AD, Wang C, Cheng YQ, Jaskula-Sztul R, Yu X, Chen H. The Novel Histone Deacetylase Inhibitor Thailandepsin A Inhibits Anaplastic Thyroid Cancer Growth. Journal of Surgical Research. 2014; 190:191-197. NIHMSID#570187
  148. Mok VM, Oltmann SC, Chen H, Sippel RS, Schneider DF. Identifying Predictors of a Difficult Thyroidectomy. Journal of Surgical Research. 2014; 190:157-163. NIHMSID#575946
  149. Singhal S, Sippel RS, Chen H, Schneider DF. Distinguishing Classical Papillary Thyroid Microcancers From Follicular-Variant Microcancers. Journal of Surgical Research. 2014; 190:151-156. NIHMSID#575289
  150. Elfenbein DM, Schneider DF, Chen H, Sippel RS. Surgical Site Infection after Thyroidectomy: Rare but Significant. Journal of Surgical Research. 2014; 190:170-176.
  151. Schneider DF, Sonderman PE, Jones MF, Ojomo KA, Chen H, Jaume JC, Elson DF, Perlman SB, Sippel RS. Failure of Radioactive Iodine in Treatment of Hyperthyroidism. Annals of Surgical Oncology (in press).
  152. Oltmann SC, Schneider DF, Chen H, Sippel RS. All thyroid ultrasound evaluations are not equal: Sonographers specialized in thyroid cancer correctly label clinical N0 disease in well differentiated thyroid cancer. Annals of Surgical Oncology (in press).
  153. Schneider DF, Elfenbein D, Lloyd RV, Chen H, Sippel RS. Lymph Node Metastases Do Not Impact Survival In Follicular Variant Papillary Thyroid Cancer. Annals of Surgical Oncology (in press). NIHMSID# 603596.
  154. Hsu KT, Yu X, Audhya A, Jaume JC, Lloyd R, Miyamoto S, Prolla T, Chen H. Novel Approaches in Anaplastic Thyroid Cancer Therapy. The Oncologist (in press).
  155. Oltmann SC, Brekke AV, Schneider DF, Schaefer SC, Chen H, Sippel RS. Preventing post-operative hypocalcemia in Graves’ patients: A prospective study. Annals of Surgical Oncology (in press).
Recent UW Parathyroid Surgery Publications
  1. Chen H, Zeiger MA, Gordon TA, Udelsman R. Parathyroidectomy in Maryland: effects of an endocrine center. Surgery. 1996; 120:948-953.
  2. Chen H, Parkerson S, Udelsman R. Parathyroidectomy in the elderly: do the benefits outweigh the risks? World J Surg. 1998; 22:531-536.
  3. Chen H, Sokoll L, Udelsman R. Outpatient minimally invasive parathyroidectomy: a combination of sestamibi-SPECT localization, cervical block anesthesia, and intraoperative PTH assay. Surgery. 1999; 126:14-18.
  4. Chen H, Cilvelek C, Westra WH, Scheel P, Udelsman R. The Use of Technetium-99m Sestamibi Scintigraphy for Recurrent Tertiary Hyperparathyroidism from an Implanted Forearm Graft. Southern Med J. 2000; 93:215-217.
  5. Girotto JA, Harmon JW, Ratner LE, Nicol TL, Wong L, Chen H. Parathyroidectomy Promotes Wound Healing and Prolongs Survival in Patients with Calciphylaxis From Secondary Hyperparathyroidism. Surgery. 2001; 130:645-651.
  6. Nichol PF, Starling JR, Mack E, Klovning JJ, Becker BN, Chen H. Long-term Follow-up of Patients with Tertiary Hyperparathyroidism Treated by Resection of a Single or Double Adenoma. Ann Surg. 2002; 235:673-680.
  7. O’Herrin JK, Weigel T, Wilson M, Chen H. Radioguided Parathyroidectomy via VATS Combined with Intraoperative Parathyroid Hormone Testing: the Surgical Approach of Choice for Patients with Mediastinal Parathyroid Adenomas? Journal of Bone and Mineral Research. 2002; 17:1368-1371.
  8. Chen H. Surgery for Primary Hyperparathyroidism: What is the Best Approach? Ann Surg. 2002; 236:552-553.
  9. Sippel RS, Bianco J, Chen H. Radioguided Parathyroidectomy for Recurrent Hyperparathyroidism due to Forearm Graft Hyperplasia. Journal of Bone and Mineral Research. 2003;18:939-942.
  10. Nichol PF, Mack E, Bianco J, Hayman A, Starling JR, Chen H. Radioguided Parathyroidectomy in Patients with Secondary and Tertiary Hyperparathyroidism. Surgery. 2003; 238:332-338.
  11. Chen H, Mack E, Starling JR. Radioguided Parathyroidectomy is Equally Effective for Both Adenomatous and Hyperplastic Glands. Ann Surg. 2003; 238:332-338.
  12. Sippel RS, Bianco JA, Wilson M, Perlman S, Ozgul O, Mack E, Starling JR, Chen H. Can Thallium-Pertechnetate Subtraction Scanning Play a Role in the Pre-Operative Imaging for Minimally Invasive Parathyroidectomy? Clinical Nuclear Medicine. 2004; 29:21-26.
  13. Sippel RS, Chen H. Multiple Endocrine Neoplasia. In: Goldin SB, Zervos EE, eds. Pocket Surgical Oncology. Philadelphia, PA: PocketMedicine.com, Inc. 2003.
  14. Frydman J, Bianco J, Drezner M, Chen H. Thallium-Pertechnetate Subtraction Scanning in the Preoperative Localization of an Ectopic Undescended Parathyroid Gland. Clinical Nuclear Medicine. 2004; 29:542-44.
  15. Satchie BN, Chen H. Radioguided Techniques for Parathyroid Surgery. Asian Journal of Surgery. 2005; 28:77-81.
  16. Sippel RS, Becker YT, Odorico JS, Springman S, Chen H. Does Propofol Anesthesia Affect Intraoperative Parathyroid Hormone Levels: A Randomized, Prospective Trial. Surgery. 2004; 136:1138-42.
  17. Chen H. Radioguided Parathyroid Surgery. In: Cameron JL, ed. Advances in Surgery. Philadelphia, PA: Elsevier, Inc., 2004; pp 377-392.
  18. Weigel TL, Murphy J, Kabbani L, Ibele A, Chen H. Radioguided Thoracoscopic Mediastinal Parathroidectomy with Intraoperative Parathyroid Hormone Testing. Annals of Thoracic Surgery. 2005; 80:1262-1265.
  19. Haustein SV, Mack E, Starling JR, Chen H. The Role of Intraoperative Parathyroid Hormone Testing in Patients with Tertiary Hyperparathyroidism after Renal Transplantation. Surgery. 2005; 138:1066-1071.
  20. Pruhs ZM, Starling JR, Mack E, Chen H. Changing Trends for Surgery in Elderly Patients with Hyperparathyroidism at a Single Institution. Journal of Surgical Research. 2005; 127:59-62.
  21. Chen H, Pruhs ZM, Starling JR, Mack E. Intraoperative Parathyroid Hormone Testing Improves Cure Rates in Patients Undergoing Minimally Invasive Parathyroidectomy. Surgery. 2005; 138:583-590.
  22. Chen H, Mack E, Starling JR. A Comprehensive Evaluation of Peri-operative Adjuncts during Minimally Invasive Parathyroidectomy: Which is Most Reliable? Ann Surg. 2005; 242:375-383.
  23. Couto MF, Blank R, Chen H, Drezner M. Calciphylaxis in the Absence of End Stage Renal Disease. Endocrine Practice. 2006; 12:406-410.
  24. Duffy A, Schurr M, Warner T, Chen H. Long-term Outcomes in Patients with Calciphylaxis from Hyperparathyroidism. Annals of Surgical Oncology. 2006; 13:96-102.
  25. Wild JL, Weigel T, Chen H. The need for intraoperative parathyroid hormone monitoring during radioguided parathyroidectomy via video-assisted thoracoscopy (VATS). Clinical Nuclear Medicine. 2006; 31:9-12.
  26. Chen H. A novel PTH (1-84) assay as basis for PTH monitoring in renal hyperparathyroidism-invited critique. Archives of Surgery. 2006; 141:134.
  27. Conrad DN, Olson JE, Hartwig HM, Mack E, Chen H. A Prospective Evaluation of Novel Methods to Intraoperatively Distinguish Parathyroid Tissue Utilizing a Parathyroid Hormone Assay. Journal of Surgical Research. 2006; 133:38-41.
  28. Sippel RS, Chen H. Primary Hyperparathyroidism. In: Pollack RE, Curley SA, Ross MI, Perrier ND, eds. Advanced Therapy in Surgical Oncology. Ontario, Canada: BC Decker Inc. 2008; 371-377.
  29. Chen H. Hyperparathyroidism: Primary and Secondary. In: Bland KI, Buchler MW, Csendes A, Garden OJ, Sarr MG, Wong J, eds. General Surgery: Principles and International Practice. Guilford, UK: Springer-Verlag. 2009; 1676-1686.
  30. Olson JE, Repplinger D, Bianco J, Chen H. Ex-vivo Radioactive Counts and Decay Rates of Tissues Resected During Radioguided Parathyroidectomy. Journal of Surgical Research. 2006; 136:187-191.
  31. Sippel RS, Chen H. Reoperative Endocrine Surgery. In: Callery M, ed. Handbook of Reoperative General Surgery. Maiden, MA: Blackwell Publishing, Inc., 2006; 135-150.
  32. Black MJ, Ruscher AE, Lederman J, Chen H. Local/Cervical Block Anesthesia versus General Anesthesia for Minimally Invasive Parathyroidectomy: What are the Advantages? Annals of Surgical Oncology. 2007; 14:744-749.
  33. Lal A, Bianco J, Chen H. Radioguided parathyroidectomy in patients with familial hyperparathyroidism. Annals of Surgical Oncology. 2007; 14:739-743.
  34. Ito F, Sippel RS, Lederman J, Chen H. The Utility of Intraoperative Bilateral Internal Jugular Venous Sampling with Rapid Parathyroid Hormone Testing. Ann Surg. 2007; 245:959-963.
  35. Placzkowski K, Christian R, Chen H. Radioguided parathyroidectomy for recurrent parathyroid cancer. Clinical Nuclear Medicine. 2007; 32:358-360
  36. Egan KR, Adler JT, Olson JE, Chen H. Parathyroidectomy for primary hyperparathyroidism in octogenarians and nonagenarians: a risk-benefit analysis. Journal of Surgical Research. 2007; 140:194-198.
  37. Lal A, Chen H. The Negative Sestamibi Scan: Is a Minimally Invasive Parathyroidectomy Still Possible? Annals of Surgical Oncology. 2007; 14:2362-2366.
  38. Carneiro-Pla DM, Irvin GL, Chen H. Consequences of parathyroidectomy in patients with "mild" sporadic primary hyperparathyroidism. Surgery. 2007; 142:795-799.
  39. Adler JT, Sippel RS, Chen H. The influence of surgical approach on quality of life after parathyroid surgery. Annals of Surgical Oncology. 2008; 15:1559-1565.
  40. Adler JT, Sippel RS, Chen H. Quality of Life in Primary Hyperparathyroidism.  Review of Endocrinology. 2008; 1-4.
  41. Pitt SC, Chen H. Minimally Invasive Parathyroidectomy: Gamma Probe Guided. In: Clark OH, Duh QY, Kebebew E, eds. Atlas of Endocrine Surgery Techniques Saunders Elsevier. 2010; pp 165-179.
  42. Cayo AK, Chen H. Radioguided Reoperative Parathyroidectomy for Persistent Primary Hyperparathyroidism. Clinical Nuclear Medicine. 2008; 33:668-670.
  43. Pinchot SN, Chen H, Sippel RS. Incisions and Exposure of the Neck for Thyroidectomy and Parathyroidectomy. Operative Techniques in General Surgery. 2008; 10:63-76.
  44. Adler JT, Chen H. Preserving function and quality of life after thyroid and parathyroid surgery. Lancet Oncology. 2008; 9:1069-1075.
  45. Adler JT, Sippel RS, Schaefer S, Chen H. Surgery improves quality of life in patients with "mild" hyperparathyroidism. Am. J. Surg. 2009; 197:284-290.
  46. Adler JT, Pinchot SN, Sippel RS, Chen H. Principles of minimally invasive parathyroidectomy. Current Medical Imaging Reviews. 2008; 4:250-254.
  47. Ning L, Sippel RS, Schaefer S, Chen H. What is the clinical significance of an elevated parathyroid hormone level after curative surgery for primary hyperparathyroidism? Annals of Surgery. 2009; 249:469-472.
  48. Chen H, Sippel RS, Schaefer S. Is Radioguided Parathyroidectomy Effective in Patients with negative sestamibi scans? Archives of Surgery. 2009; 144:643-648.
  49. Pitt SC, Panneerselvan R, Sippel RS, Chen H. Radioguided Parathyroidectomy for Hyperparathyroidism in the Reoperative Neck. Surgery. 2009; 146:592-598.
  50. Repplinger D, Schaefer S, Chen H, Sippel RS. Neurocognitive dysfunction: a risk factor for parathyroid hyperplasia. Surgery. 2009; 146:1138-1143.
  51. Pitt SC, Panneerselvan R, Chen H, Sippel RS. Tertiary hyperparathyroidism: Is less than a subtotal resection ever appropriate? A study of long-term outcomes. Surgery. 2009; 146:1130-1137.
  52. Pitt SC, Sippel RS, Chen H. Secondary and Tertiary Hyperparathyroidism, State of the Art Management. Surg Oncol Clin N Am. 2009; 89: 1227-1239.
  53. Pinchot SN, Chen H. Non-operative management of primary hyperparathyroidism: The exception rather than the rule. Expert Reviews in Endocrinology and Metabolism. 2009; 4:553-563.
  54. Pitt SC, Panneerselvan R, Sippel RS, Chen H. Influence of Morbid Obesity on Parathyroidectomy Outcomes in Primary Hyperparathyroidism. Am. J. Surg. 2010; 199:410-4.
  55. Cayo AK, Sippel RS, Schaefer S, Chen H. The Utility of Intra-Operative PTH for Primary Hyperparathyroidism due to Multi-Gland Disease. Annals of Surgical Oncology. 2009; 16:3450-3455.
  56. Lairmore TC, Chen H. The Role of Menin in Neuroendocrine Tumorigenesis. In: Balogh K, Patócs A, eds. Advances in Experimental Medicine and Biology. Vol.668; Super MEN1. New York, NY: Springer. 2009; pp 87-95.
  57. Kelly KJ, Chen H, Sippel RS. Primary Hyperparathyroidism. Cancer Treat Res. 2010; 153:87-103.
  58. Cook MR, Pitt SC, Schaefer S, Sippel RS, Chen H. A Rising IoPTH Level Immediately After Parathyroid Resection: Are Additional Hyperfunctioning Glands Always Present? An application of the “Wisconsin Criteria”. Annals of Surgery. 2010; 251:1127-30.
  59. Durkin ET, Nichol PF, Lund DP, Chen H, Sippel RS. What is the optimal treatment for children with primary hyperparathyroidism? Journal of Pediatric Surgery. 2010; 45:1142-1146.
  60. Pitt SC, Panneerselvan R, Chen H, Sippel RS. Secondary and Tertiary Hyperparathyroidism: The Utility of ioPTH Monitoring. World Journal of Surgery. 2010; 34(6):1343-9. NIHMSID #216005
  61. Adler JT, Sippel RS, Chen H. 25-hydroxyvitamin D status does not affect intraoperative parathyroid hormone dynamics in patients with primary hyperparathyroidism. Annals of Surgical Oncology. 2010; 17:2958-2962.
  62. Chen H, Wang TS, Yen TW, Doffek K, Krzywd E, Schaefer S, Sippel RS, Wilson SD. Operative Failures after Parathyroidectomy for Hyperparathyroidism: the Influence of Surgical Volume. Annals of Surgery. 2010; 252:691-695.
  63. Adler JT, Chen H, Schaefer S, Sippel RS. Does routine use of ultrasound result in additional thyroid procedures in patients with primary hyperparathyroidism? Journal of the American College of Surgeons. 2010; 211:536-539.
  64. Zarebczan B, Rajamanickam V, Leverson G, Chen H, Sippel RS. Training our Future Endocrine Surgeons: A Look at the Endocrine Surgery Operative Experience of U.S. Surgical Residents. Surgery. 2010; 148:1075-1081.
  65. Roy M, Rajamanickam V, Chen H, Sippel RS Is DVT Prophylaxis Necessary for Thyroidectomy and Parathyroidectomy? Surgery. 2010; 148:1163-1169.
  66. Adler JA, Stack BC, Chen H. Radioguided Parathyroid Exploration. In Randolph GW, ed. Surgery of the Thyroid and Parathyroid Glands (in press).
  67. Adler JA, Sippel RS, Chen H. New Trends in Parathyroid Surgery. Current Problems in Surgery. 2010; Mosby, NY:NY pp949-1020.
  68. Chen H, Sippel RS. Sometimes Less is More. Archives of Surgery. 2011; 146:710.
  69. Chen H. Primary Hyperparathyroidism. In: Cameron A, Cameron JL, eds. Current Surgical Therapy 10th ed. St. Louis, MO. 2011; pp610-613.
  70. Woll M, Sippel RS, Chen H. Does Previous Head and Neck Irradiation Increase the Chance of Multi-gland Disease in Patients with Hyperparathyroidism? Annals of Surgical Oncology. 2011; 18:2240-2244.
  71. Gabr E, Carter Y, Alhefdhi A, Sippel RS, Chen H. The Use of Radioguided Technology to Localize Intrathyroidal Parathyroid Glands. Journal of Dialog in Endocrinology. 2011; 8:35-38.
  72. Zarebczan B, Chen H. Influence of Surgical Volume on Operative Failures for Hyperparathyroidism. In: Cameron JL, ed. Advances in Surgery. Philadelphia, PA: Elsevier, Inc. 2011; 45:231-248.
  73. Adler JA, Sippel RS, Chen H. Clinical Management of Primary Hyperparathyroidism. In: Sippel RS, Chen H, eds. Handbook of Endocrine Surgery. Hackensack, NJ: World Scientific. 2011.
  74. Mazeh H, Chen H. Intraoperative Adjuncts for Parathyroid Surgery. Expert Rev Endocrinol Metab 2011; 6(2):245-253.
  75. Alhefdhi A, Pinchot SN, Davis R, Sippel RS, Chen H. The Necessity and Reliability of Intraoperative Parathyroid Hormone (PTH) Testing in Patients with Mild Hyperparathyroidism and PTH Levels in the Normal Range. World J Surg. 2011; 35:2006-2009.
  76. Bargren AE, Repplinger D, Chen H, Sippel RS. Can Biochemical Abnormalities Predict Symptomatology in Patients with Primary Hyperparathyroidism? Journal of the American College of Surgeons. 2011; 213:410-414.
  77. Adler JT, Chen H, Schaefer S, Sippel RS. What is the added benefit of cervical ultrasound to 99mTc-sestamibi scanning in primary hyperparathyroidism? Annals of Surgical Oncology. 2011; 18:2907-2911.
  78. Grayev AM, Gentry LR, Hartman MJ, Chen H, Perlman S, Reeder SB. Presurgical Localization of Parathyroid Adenomas with Magnetic Resonance Imaging at 3.0T: An Adjunct Method to Supplement Traditional Imaging. Annals of Surgical Oncology. 2012; 19:981-989.
  79. Mazeh H, Sippel RS, Chen H. Three large functioning cystic parathyroid adenomas. Endocrine Practice. 2011; 8:1-11.
  80. Mazeh H, Stoll SJ, Robbins J, Sippel RS, Chen H. Validation of the “Perrier” parathyroid adenoma location nomenclature. World J Surg.. 2012; 36:612-616.
  81. Woll ML, Mazeh H, Anderson BM, Chen H, Sippel RS. Breast radiation correlates with side of parathyroid adenoma. World J Surg. 2012; 36:607-11.
  82. Prichard RS, O’Neill, CJ, Oucharek JJ, Sippel RS, Delbridge LW, Sidhu SB, Chen H. Is Focused Minimally Invasive Parathyroidectomy Appropriate for Patients With Familial Primary Hyperparathyroidism? Annals of Surgical Oncology. 2012; 19:1264-1268.
  83. Wood K, Dhital S, Chen H, Sippel RS. What is the utility of distal forearm DXA in primary hyperparathyroidism? The Oncologist. 2012; 17:322-325.
  84. Reiher AE, Schaefer S, Chen H, Sippel RS. Does the final intra-operative PTH level really have to fall into the normal range to signify cure? Annals of Surgical Oncology. 2012; 322-325.
  85. Mazeh H, Chen H, Leverson G, Sippel RS. Creation of a “Wisconsin Index” nomogram to predict the likelihood of additional hyperfunctioning parathyroid glands during parathyroidectomy. Annals of Surgery. 2013; 257:138-142.
  86. Mazeh H, Sippel RS, Chen H. The Role of Gender in Primary Hyperparathyroidism: Same Disease, Different Presentation. Annals of Surgical Oncology. 2012; 19:2958-2962.
  87. Murray S, Sippel RS, Chen H. The Incidence of Concomitant Hyperparathyroidism in Patients with Thyroid Disease Requiring Surgery. Journal of Surgical Research. 2012; 178:264-267.
  88. Adler JA, Stack BC, Chen H. Radioguided Parathyroid Exploration. In Randolph GW, ed. Surgery of the Thyroid and Parathyroid Glands. Philadelphia, PA. Elsevier. 2013; 613-619.
  89. Lubitz C, Chen H. Sestamibi-negative patients: To operate or image? Annals of Surgical Oncology. 2012; 19:2086-2087
  90. Mazeh H, Kouniavsky G, Schneider DF, Makris KI, Sippel RS, Dackiw, Chen H, Zeiger MA. Intra-thyroidal Parathyroid Glands; Small, but Mighty (A Napoleon Phenomenon). Surgery. 2012; 6:1211-1217.
  91. Reiher AE, Mazeh H, Schaefer S, Gould J, Chen H, Sippel RS. Gastro-esophageal reflux disease (GERD) symptoms improve significantly after parathyroidectomy. Surgery. 2012; 6:1232-1237.
  92. Schneider DF, Mazeh H, Sippel RS, Chen H. Is Minimally Invasive Parathyroidectomy Associated with Higher Recurrence Compared to Bilateral Exploration? Analysis of over 1000 cases. Surgery. 2012; 6:1008-1015.
  93. Pinchot SN, Youngwirth L, Rajamanickam V, Schaefer S, Sippel RS, Chen H. Changes in swallowing-related quality of life after parathyroidectomy for hyperparathyroidism: A prospective cohort study. The Oncologist. 2012; 17:1271-1276.
  94. Zia S, Sippel RS, Chen H. Sestamibi Imaging for Primary Hyperparathyroidism: the Impact of Surgeon Interpretation and Radiologist Volume. Annals of Surgical Oncology. 2012; 19:3827-3831.
  95. Roy M, Mazeh H, Chen H, Sippel RS. Incidence and Localization of Ectopic Parathyroid Adenomas in Previously Unexplored Patients. World J Surg. 2013; 37:102-106.
  96. Mazeh H, Chen H. Intra-operative Parathyroid Hormone Monitoring. In: Kountakis S. (Ed.). Encyclopedia of Otolaryngology, Head and Neck Surgery. New York, NY: Springer. 2013; 323.
  97. Lee J, Mazeh H, Serpell JW, Delbridge L, Chen H, Sidhu S. Adenomas of cervical maldescended parathyroid glands-pearls and pitfalls. ANZ Journal of Surgery (in press).
  98. Burke JF, Naraharisety K, Schneider DF, Sippel RS, Chen H. Early Phase Technetium 99m-Sestamibi Scintigraphy Can Improve Preoperative Localization in Primary Hyperparathyroidism. Am. J. Surg.. 2013; 205:269-273.
  99. Oltmann SC, Chen H. Minimally Invasive Radioguided Parathyroidectomy. Curr Surg Rep. DOI 10.1007/s40137-012-0001-y.
  100. Shepet K, Alhefdhi A, Usedom R, Sippel RS, Chen H. Parathyroid cryopreservation following parathyroidectomy: a worthwhile practice? Annals of Surgical Oncology. 2013; 20:2256-2260. NIHMSID #449393
  101. Schneider DF, Ojomo KA, Mazeh H, Oltmann SC, Sippel RS, Chen H. Significance of rebounding parathyroid hormone levels during parathyroidectomy. Journal of Surgical Research. 2013; 184:265-268.
  102. Clark N, Schneider DF, Vrabec S, Bauer P, Chen H, Sippel RS. Increased Efficiency of Endocrine Procedures Performed in an Ambulatory Room. Journal of Surgical Research. 2013; 184:200-203.
  103. Burke JF, Jacobson K, Gosain A, Sippel RS, Chen H. Radioguided Parathyroidectomy Effective in Pediatric Patients. Journal of Surgical Research. 2013; 184:312-317.
  104. Mazeh H, Chen H (2013). Minimally Invasive Parathyroidectomy. In: Stilianos E. Kountakis (Ed.). Encyclopedia of Otolaryngology, Head and Neck Surgery. New York, NY: Springer, p 1699.
  105. Mazeh H, Chen H (2013). Multi-gland Disease. In: Stilianos E. Kountakis (Ed.). Encyclopedia of Otolaryngology, Head and Neck Surgery. New York, NY: Springer, p 1716.
  106. Mazeh H, Chen H (2013). Preoperative Localization Studies. In: Stilianos E. Kountakis (Ed.). Encyclopedia of Otolaryngology, Head and Neck Surgery. New York, NY: Springer, p 2187.
  107. Mazeh H, Chen H (2013). Primary Hyperparathyroidism. In: Stilianos E. Kountakis (Ed.). Encyclopedia of Otolaryngology, Head and Neck Surgery. New York, NY: Springer, p 2200.
  108. Schneider DF, Burke JF, Ojomo KA, Clark N, Mazeh H, Sippel, RS, Chen H. Multigland Disease and Slower Decline in Intraoperative PTH Characterize Mild Primary Hyperparathyroidism. Annals of Surgical Oncology. 2013; 20:4205-4211.
  109. Oltmann, SC, Schneider DF, Sippel RS, Chen H. Presentation, Management and Outcomes of Hyperparathyroidism in Octogenarians and Nonagenarians. Annals of Surgical Oncology. 2013; 20:4195-4199.
  110. Ahmed K, Alhefdhi A, Schneider DF, Ojomo KA, Sippel RS, Chen H, Mazeh H. Minimal benefit to subsequent intraoperative parathyroid hormone testing after all four glands have been identified. Annals of Surgical Oncology. 2013; 20:4200-4204.
  111. Schneider DF, Chen H, Mazeh H, Sippel RS. Predictors of Recurrences in Primary Hyperparathyroidism: an Analysis of 1,386 Cases. Annals of Surgery. 2014; 259:563-568.
  112. Sippel RS, Chen H. Radioguided Parathyroid Surgery. In: Terris DJ, Duke WS, Pasieka J, eds. Parathyroid Surgery: Fundamental and Advanced Concepts. San Diego, CA: Plural Publishing Inc. (in press).
  113. Murray SE, Pathak PR, Pontes DS, Schaefer SC, Chen H, Sippel RS. Improvement of Sleep Disturbance and Insomnia Following Parathyroidectomy for Primary Hyperparathyroidism. World J Surg. 2014; 38:542-548. NIHMSID#528575.
  114. Murray SE, Pathak PR, Pontes DS, Schneider DF, Schaefer SC, Chen H, Sippel RS. Timing of Symptom Improvement After Parathyroidectomy for Primary Hyperparathyroidism. Surgery. 2013; 154:1463-1469.
  115. Alhefdhi A, Schneider DF, Sippel RS, Chen H. Recurrent and Persistence Primary Hyperparathyroidism Occurs More Frequently in Patients with Double Adenomas. Journal of Surgical Research. 2014; 190:198-202.
  116. Pathak PR, Holden SE, Schaefer SC, Leverson G, Chen H, Sippel RS. Elevated PTH After Parathyroidectomy Delays Symptom Improvement. Journal of Surgical Research. 2014; 190:119-125. NIHMSID#571292
  117. Weiss DM, Chen H. Role of Cervical Ultrasound in Detecting Thyroid Pathology in Primary Hyperparathyroidism. Journal of Surgical Research. 2014; 190:575-578.
  118. Oltmann SC, Rajaei MH, Sippel RS, Chen H, Schneider DF. Primary hyperparathyroidism throughout the ages: Disease presentation, characteristics and outcomes. Journal of Surgical Research. 2014; 190:185-190.
  119. Rajaei MH, Oltmann SC, Adkisson CD, Elfenbein DM, Chen H, Carty SE, McCoy KL. Is intraoperative parathyroid hormone monitoring necessary with ipsilateral gland visualization during anticipated unilateral exploration for primary hyperparathyroidism: a multi-institutional analysis of over 2000 patients? Surgery (in press).
  120. Oltmann SC, Brekke AV, Macatangay JD, Schneider DF, Chen H, Sippel RS. Surgeon and staff radiation exposure during radioguided parathyroidectomy at a high volume institution. Annals of Surgical Oncology (in press).
  121. Hsu KT, Sippel RS, Chen H, Schneider DF. Is Central Lymph Node Dissection Necessary for Parathyroid Carcinoma? Surgery (in press). NIHMSID#60366.
  122. Burke JF, Chen H, Gosain A. Parathyroid conditions in childhood. Seminars in Pediatric Surgery. 2014; 23:66-70.
  123. Rajaei MH, Bentz AM, Schneider DF, Sippel RS, Chen H, Oltmann SC. Justified follow-up: A final ioPTH over 40 pg/mL is associated with an increased risk of persistence and recurrence in primary hyperparathyroidism. Annals of Surgical Oncology (in press).
  124. Rajaei MH, Oltmann SC, Schneider DF, Sippel RS, Chen H. Outcomes after Subtotal Parathyroidectomy for Primary Hyperparathyroidism due to Hyperplasia: Significance of Whole vs. Partial Gland Remnant. Annals of Surgical Oncology (in press).
  125. Elfenbein DM, Weber S, Schneider DF, Sippel RS, Chen H. CaPTHUS Scoring Model in Primary Hyperparathyroidism: Can it Eliminate the need for ioPTH? Annals of Surgical Oncology (in press). NIHMSID#623467.
  126. Burke JA, Chen H, Gosain A. Parathyroid Surgery in Children. Seminars in Pediatric Surgery. 2014.
  127. Oltmann SC, Chen H. Radioguided Parathyroidectomy. In: TerrisDJ, Singer MC, eds. Minimally Invasive and Robotic Thyroid and Parathyroid Surgery. New York, NY: Springer 2014. pp 151-156.
Recent UW Adrenal Surgery Publications
  1. Chen H, Doppman JL, Chrousos GP, Norton JA, Nieman LK, Udelsman R. Adrenocorticotropic hormone-secreting pheochromocytomas: the exception to the rule. Surgery. 1995; 118:988-995.
  2. Raza SA, DeWitt RT, Chen H, Warner TF, Blank RD. Catecholamine Excess in Pheochromocytoma Inducing Insulin Resistance. Endocrine Practice. 2004; 10: 149-152.
  3. Sippel RS, Chen H. Subclinical Cushing's Syndrome in Adrenal Incidentalomas. Surg Clin North America. 2004; 84: (3) 875-885.
  4. Kappes A, Vaccaro A, Kunnimalaiyaan M, Chen H. ZM336372, a Raf-1 Activator, Inhibits Growth of Pheochromocytoma Cells. Journal of Surgical Research. 2006; 133:43-45.
  5. Adler JT, Mack E, Chen H. Equal oncologic results for laparoscopic and open resection of adrenal metastases. Journal of Surgical Research. 2007; 140: 159-164.
  6. Kappes A, Vaccaro A, Kunnimalaiyaan M, Chen H. Lithium ions: A novel treatment for pheochromocytomas and paragangliomas. Surgery. 2007; 141:(2) 161-165.
  7. Adler JT. Mack E. Chen H. Isolated adrenal mass in patients with a history of cancer: remember pheochromocytoma. Annals of Surgical Onclogy. 2007; 14:2358-2362.
  8. Greenblatt DY, Shenker Y, Chen H. The Utility of Metaiodobenzylguanidine (MIBG) Scintigraphy in Patients with Pheochromocytoma. Annals of Surgical Oncology. 2008; 15:900-905.
  9. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H.  Histone deacetylase inhibitors upregulate Notch1 and inhibit growth in pheochromocytoma cells.  Surgery. 2008; 144:956-961.
  10. Adler JT, Meyer-Rochow GY, Chen H, Benn DE, Robinson BG, Sippel RS, Sidhu SB. Pheochromocytoma: current approaches and future directions. The Oncologist. 2008; 13:779-793.
  11. Cayo MA, Cayo AK, Jarjour SM, Chen H. Sodium butyrate activates Notch1 signaling, reduces tumor markers, and induces cell cycle arrest and apoptosis in pheochromocytoma. American Journal of Translational Research. 2009; 249: 469-472.
  12. Ballian N, Adler JT, Sippel RS, Chen H. Revisiting adrenal mass size as an indication for adrenalectomy. Journal of Surgical Research. 2009; 156:16-20.
  13. Pinchot SN, Sippel RS, Chen H. ACTH-producing carcinoma of the pituitary with refractory Cushing's Disease and hepatic metastases: A case report and review of the literature. World Journal of Surgical Oncology. 2009; 7: 39-42.
  14. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Inhibition of the PI3K pathway suppresses hormonal secretion and limits growth in pheochromocytoma cells. World Journal of Surgery. 2009; 33:2452-2457.
  15. Sippel RS, Elaraj DM, Kebebew E, Lindsay S, Tyrrell JB, Duh QY. Waiting for change: symptom resolution after adrenalectomy for Cushing's syndrome. Surgery. 2008 Dec; 144(6):1054-60; discussion 1060-1.
  16. Chen H, Sippel RS, O’Dorisio MS, Vinik AI, Lloyd RV, Pacak K. The NANETS Consensus Guideline for the Diagnosis and Management of Neuroendocrine Tumors: Pheochromocytoma, Paraganglioma, and Medullary Thyroid Cancer. Pancreas. 2010; 39:775-783.
  17. Meyer-Rochow GY, Jackson NE, Conaglen JV, Whittle DE, Kunnimalaiyaan M, Chen H, Westin G, Sandberg J, Stålberg P, Barker C, Khanafshar E, Shibru D, Duh QY, Clark OH, Kebebew E, Gill AJ, Clifton-Bligh R, Robinson BG, Benn DE, Sidhu SB. MicroRNA profiling of pheochromocytoma tumors identifies novel diagnostic and therapeutic targets. Endocrine-Related Cancers. 2010; 17:835-846.
  18. Alhefdhi A, Chen H. Pheochromocytoma. Encyclopedia of Cancer, 3rd ed. Springer-Verlag. 2010.
  19. Carter Y, Mazeh H, Sippel RS, Chen H. Laparoscopic resection is safe and feasible for large (>6cm) pheochromocytomas without suspicion of malignancy. Endocrine Practice. 2012; 18:720-726.
  20. Mazeh H, Froyshteter AB, Wang T, Amin A, Evans D, Sippel RS, Chen H, Yen T. Is Prior Same Quadrant Surgery a Contraindication to Laparoscopic Adrenalectomy? Surgery. 2012; 6:1211-1217.
  21. Carter Y, Roy M, Sippel RS, Chen H. Persistent hypertension after adrenalectomy for an aldosterone-producing adenoma: weight as a critical prognostic factor for aldosterone's lasting effect on the cardiac and vascular systems. Journal of Surgical Research. 2012; 177:241-247.
  22. Oltmann SC, Chen H. Doing Away with the Rule of 10%. Annals of Surgical Oncology. 2013; 20:1403–1404.

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