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Transplantation, University of Wisconsin - Madison
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Yolanda T. Becker, MD
William Burlingham, PhD
Anthony M. D'Alessandro, MD
Anthony M. D'Alessandro, MD
Niloo M. Edwards, MD
Luis A. Fernandez, MD
David Foley, MD
Stuart J. Knechtle, MD
Josh Mezrich, MD
Jon S. Odorico, MD
John D. Pirsch, M.D.
Hans W. Sollinger, M.D., Ph.D.
James Southard, M.D.
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William J. Burlingham, PhD

Photo of William J. Burlingham, PhD

Professor, Division of Transplantation

H4/749 Clinical Science Center
600 Highland Avenue
Madison, WI 53792-7375

Office: (608) 263-0119

FAX: (608) 263-7652

Lab Website

Send an email to William J. Burlingham, PhD burlingham@surgery.wisc.edu

Education

  • PhD, Biology, Syracuse University, Syracuse, NY, 1979
  • Postdoctoral Research Fellowship, National Cancer Institute, Mayo Clinic and Mayo Medical School, Rochester, MN, 1980-1983

Research Interests

Dr. Burlingham has developed a highly respected transplant basic research program that focuses on acquired immunologic tolerance. His laboratory hopes to gain insight into graft acceptance by studying transplant recipients who have survived even though they have stopped taking immunosuppressive drugs.

Specifically, his research focuses on the natural exchange of soluble antigens and low numbers of white blood cells that occurs between mother and child during pregnancy and nursing. The lab's working hypothesis is that this exchange, which leads to persistence of bone marrow-derived maternal blood cells within the offspring ("microchimerism") may induce a "natural" form of tolerance. This tolerance, if harnessed, may allow for drug-free acceptance of transplanted grafts.

Link to Dr. Burlingham's Delayed Type HyperSensitivity Lab page

Active Grants

Professional Activities

Dr. Burlingham serves on the editorial board of Transplantation. He is also the chairman of the University of Wisconsin Spring Immunology Seminar Series.

Recent Publications

  • Hayney MS, Moran J, Wiegert NA, Burlingham WJ. Lung transplant patients' T cell responses to influenza vaccine viruses between seasons., Vaccine. 2008 May 19;26(21):2596-600.
    [PubMed ID: 18420314]
  • Bobadilla JL, Love RB, Jankowska-Gan E, Xu Q, Haynes LD, Braun RK, Hayney MS, Munoz del Rio A, Meyer K, Greenspan DS, Torrealba J, Heidler KM, Cummings OW, Iwata T, Brand D, Presson R, Burlingham WJ, Wilkes DS. Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation., Am. J. Respir. Crit. Care Med. 2008 Mar 15;177(6):660-8.
    [PubMed ID: 18174545]
  • Kwun J, Hu H, Schadde E, Roenneburg D, Sullivan KA, DeMartino J, Burlingham WJ, Knechtle SJ. Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients., J. Immunol. 2007 Dec 15;179(12):8016-25.
    [PubMed ID: 18056341]
  • Molitor-Dart ML, Andrassy J, Kwun J, Kayaoglu HA, Roenneburg DA, Haynes LD, Torrealba JR, Bobadilla JL, Sollinger HW, Knechtle SJ, Burlingham WJ. Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance., J. Immunol. 2007 Nov 15;179(10):6749-61.
    [PubMed ID: 17982065]
  • Burlingham WJ, Love RB, Jankowska-Gan E, Haynes LD, Xu Q, Bobadilla JL, Meyer KC, Hayney MS, Braun RK, Greenspan DS, Gopalakrishnan B, Cai J, Brand DD, Yoshida S, Cummings OW, Wilkes DS. IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants., J. Clin. Invest. 2007 Nov;117(11):3498-506.
    [PubMed ID: 17965778]
  • All Publications

 

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Transplantation - University of Wisconsin Department of Surgery
First published: 07/15/02 Last updated: 07/25/08 webmaster@surgery.wisc.edu
Copyright © 2006 The Board of Regents of the University of Wisconsin System