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William J. Burlingham, PhD
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Professor, Division of Transplantation
H4/749 Clinical Science Center
600 Highland Avenue
Madison, WI 53792-7375
Office: (608) 263-0119
FAX: (608) 263-7652
Lab Website
burlingham@surgery.wisc.edu
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Education
- PhD, Biology, Syracuse University, Syracuse, NY, 1979
- Postdoctoral Research Fellowship, National Cancer Institute, Mayo Clinic
and Mayo Medical School, Rochester, MN, 1980-1983
Research Interests
Dr. Burlingham has developed a highly respected transplant basic research program
that focuses on acquired immunologic tolerance. His laboratory hopes to gain
insight into graft acceptance by studying transplant recipients who have survived
even though they have stopped taking immunosuppressive drugs.
Specifically, his research focuses on the natural exchange of soluble antigens
and low numbers of white blood cells that occurs between mother and child during
pregnancy and nursing. The lab's working hypothesis is that this exchange, which
leads to persistence of bone marrow-derived maternal blood cells within the
offspring ("microchimerism") may induce a "natural" form
of tolerance. This tolerance, if harnessed, may allow for drug-free acceptance
of transplanted grafts.
Link to Dr. Burlingham's Delayed Type HyperSensitivity Lab page
Active Grants
Professional Activities
Dr. Burlingham serves on the editorial board of Transplantation. He is also
the chairman of the University of Wisconsin Spring Immunology Seminar Series.
Recent Publications
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Dutta P, Molitor-Dart M, Bobadilla JL, Roenneburg DA, Yan Z, Torrealba JR, Burlingham WJ.
Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice.,
Blood.
2009 Oct 22;114(17):3578-87.
[PubMed ID: 19700665]
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Hegde S, Jankowska-Gan E, Roenneburg DA, Torrealba J, Burlingham WJ, Gumperz JE.
Human NKT cells promote monocyte differentiation into suppressive myeloid antigen-presenting cells.,
J. Leukoc. Biol.
2009 Oct;86(4):757-68.
[PubMed ID: 19465641]
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van Halteren AG, Jankowska-Gan E, Joosten A, Blokland E, Pool J, Brand A, Burlingham WJ, Goulmy E.
Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members.,
Blood.
2009 Sep 10;114(11):2263-72.
[PubMed ID: 19506299]
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Jankowska-Gan E, Sollinger HW, Pirsch JD, Cai J, Pascual J, Haynes LD, Munoz del Rio A, Burlingham WJ.
Successful reduction of immunosuppression in older renal transplant recipients who exhibit donor-specific regulation.,
Transplantation.
2009 Aug 27;88(4):533-41.
[PubMed ID: 19696637]
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Dutta P, Burlingham WJ.
Tolerance to noninherited maternal antigens in mice and humans.,
Current opinion in organ transplantation.
2009 Aug;14(4):439-47.
[PubMed ID: 19512930]
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Transplantation
- University of Wisconsin Department of Surgery
First published: 07/15/02 Last updated: 11/07/09
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Copyright © 2006 The Board of Regents of the University of Wisconsin System
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