Regenerative Medicine Program – Immunology/Pathology Core
Funding:
Wisconsin Partnership Fund for a Healthy Future
Principal Investigator:
Co-Investigators:
Debra A. Hullett, PhD
Jose Torrealba, MD
Lab Website:
(Lab website not available at this time)
Project Summary:
The aim of the Regenerative Medicine Program is the development of core facilities necessary to overcome roadblocks to the application of stem cell biology to clinical medicine. The program will consist of four core facilities: Stem Cell Resources, Immunology/Pathology, Non-Human Primate, and Imaging. MERC funding supports the Immunology/Pathology and Imaging cores. The core facilities will provide interdisciplinary resources to researchers, foster collaborations, and bring the promise of regenerative medicine to fruition in the form of treatments for various diseases.
The rationale for the Immunology/Pathology core is to provide investigators with assay systems to evaluate the immunogenicity of ES-derived tissue transplants. To that end the core provides services in immunology and pathology, based on 3 Aims/strategies: 1) Production of Humanized Rag2-/-,?c-/- Mice; 2) The Trans-Vivo DTH Assay; and 3) Immunohistopathology. The latter two aims complement the first, allowing a detailed analysis of cellular and humoral immunity to the ES-derived neural, cardiac, islet, and hematopoeitic cell transplants. Monkey ES cell transplant trials will also be evaluated using the techniques outlined in Aims 2 &3, adapted to the Rhesus model. The significance of the core is that it provides pre-clinical testing of the transplantability and possible immune privileges of embryonic stem cells and their progeny.
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Transplantation
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First published: 07/15/02 Last updated: 11/24/09
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