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November 7, 2003
Medical School Update
A National Institutes of Health (NIH) grant for more than $4 million
was recently awarded to the UW to fund a George M. O'Brien Urology Research
Center.
Wade Bushman, MD, PhD, is the
principal investigator of the grant entitled "Mechanisms for Acquired
Changes in Prostate Growth Regulation."
The UW O'Brien Center, funded by the National Institute of Diabetes
and Digestive and Kidney Diseases and the National Cancer Institute,
seeks to attract new scientists to investigate the mechanisms of urologic
diseases and disorders, encourage multidisciplinary research focused
on the causes of urologic diseases, and generate developmental research
that will lead to new approaches to study urologic diseases. The grant's
unifying hypothesis is that aging and the environment produce acquired
changes in prostate growth control that predispose to neoplasia. The
grant involves collaboration among investigators from the Medical School,
School of Pharmacy and School of Veterinary Medicine; includes initiatives
to attract researchers with common interests; and funds two to three
developmental projects annually.
In addition to Bushman, key investigators include David
Jarrard, MD, associate professor of surgery; Hasan Mukhtar, PhD,
professor of dermatology; Terry Oberley, MD, PhD, professor of pathology
and laboratory medicine; Richard Peterson, PhD, professor of pharmacy;
John Svaren, PhD, assistant professor of comparative biosciences; and
George Wilding, MD, professor of medicine.
F. Michael Hoffman, PhD, professor of oncology and medical genetics,
and Douglas McNeel, PhD, assistant professor of medicine, received competitive
awards for developmental projects at the onset of the grant. Funding
will be available in future years for additional developmental/pilot
and feasibility projects. Junior investigators, as well as established
investigators with new research interests related to prostate growth,
are encouraged to consider this opportunity.
Anyone with research interests that complement those of the O'Brien
Center group is encouraged to contact Bushman or one of the other investigators.
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