University of Wisconsin–Madison

Archive: Dr. Guo’s Lab

Dr. Lian-Wang Guo’s laboratory is interested in identifying novel causative processes in the development of restenosis, a common recurrent vascular disease. The long-term goal is to find better interventional avenues for effective amelioration of restenosis, through translational endeavor in close association with Dr. Craig Kent’s lab and investigators across other disciplines such as biomedical engineering and drug screening.

Dr. Guo had developed a strong record in his previous studies of PDE6-mediated molecular interactions in photoreceptor signaling critical for normal vision. Supported by NIH funding, his lab continues to investigate the potential of the sigma-1 receptor chaperone in protecting against retinal neurodegeneration as well as in preserving stem cell-derived photoreceptor progenitors transplanted for retinal regeneration, in collaboration with experts at the McPherson Eye Research Institute.