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Dai  Yamanouchi, MD, PhD

Contact Dr. Yamanouchi


(608) 265-4420

600 Highland Ave
Madison, WI 53792

Dai Yamanouchi, MD, PhD

Assistant Professor
Division of Vascular Surgery


  • MD, Gunma University, Japan, 2000
  • PhD, Gunma University, Japan, 2006
  • Surgical Internship and Residency, Gunma University Hospital, Japan, 2000-2003
  • Surgical Residency, Saiseikai Maebashi Hospital, Japan, 2001-2002
  • Research Fellowship, Nagoya University Graduate School of Medicine, Japan, 2003-2004
  • Clinical Fellowship in Vascular Surgery, Nagoya University Hospital, Japan, 2004-2007
  • Research Fellowship, Weill Cornell Medical College, New York, NY, 2007-2008
  • Fellowship in Advanced Endovascular Surgery, University of Wisconsin Madison, Madison, WI, 2009-2010

Clinical Specialties

Dr. Yamanouchi specializes in vascular and endovascular surgery. He is board certified in angiology and endovascular surgery in Japan.

Dr. Yamanouchi specializes in open and endovascular techniques for the treatment of vascular diseases. His expertise includes treatments for aortic aneurysms, carotid disease, aortic dissection, peripheral arterial disease, and other vascular disorders.

Dr. Yamanouchi provides a wide range of services including Abdominal Aortic Aneurysm (AAA) Repair - Endovascular, Abdominal Aortic Aneurysm (AAA) Repair - Open, Amputation, Angioplasty With Stent Placement, Carotid Endartecotomy, Carotid Stenting, Extended Efforts in Limb Salvage, Peripheral Artery Bypass, Thoracic Aortic Aneursym - Endovascular, Thoracic Aortic Aneursym - Open, Thoracic Outlet Syndrome Treatment, and Varicose Vein Treatment.

Research Interests

Dr. Yamanouchi’s research interests include the pathogenesis of abdominal aortic aneurysm and restenosis after angioplasty including balloon angioplasty and stent placement. He is also devoted to the development of novel materials for vascular bypass graft and gene delivery method to treat the patients who suffers peripheral arterial disease. In addition, Dr. Yamanouchi serves as principal investigator on a number of clinical trials.

Dr. Yamanouchi's Lab

Wisconsin Vascular and Endovascular Research Network (WiVERN)

Active Clinical Trials
  • A Multicenter, Open Label, Prospective, Non-randomized Study of the InCraft® Stent Graft System in Subjects With Abdominal Aortic Aneurysms (INSPIRATION)
    Principal Investigator(s): Dai Yamanouchi, MD, PhD
    Status: Active, not recruiting
    [ NCT01664078]
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  • Multicenter, Post-Market Study to Assess Outcomes of Patients Treated With the AFX System Compared to Other EVAR Devices for Endovascular Abdominal Aortic Aneurysm Repair: LEOPARD
    Principal Investigator(s): Dai Yamanouchi, MD, PhD
    Status: Enrolling by invitation
    [ NCT02407457]
    More Information

Recent Publications
  • Hyperglycemia Suppresses Calcium Phosphate-Induced Aneurysm Formation Through Inhibition of Macrophage Activation.
    Tanaka T, Takei Y, Yamanouchi D
    J Am Heart Assoc 2016 Mar; 4(3):e003062.
    [PubMed ID: 27021877]
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  • Case Report of Percutaneous Retrograde Transcollateral Recanalization of the Superior Mesenteric Artery via the Celiac Artery for Acute Mesenteric Ischemia.
    Gupta PK, Smith BK, Yamanouchi D
    Medicine (Baltimore) 2015 Dec; 94(50):e2036.
    [PubMed ID: 26683911]
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  • Postdischarge outcomes after endovascular abdominal aortic aneurysm repair.
    Gupta PK, Engelbert TL, Ramanan B, Fang X, Yamanouchi D, Hoch JR, Acher CW
    J. Vasc. Surg. 2014 Apr; 59(4):903-8.
    [PubMed ID: 24360236]
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  • Current status of medical treatment for abdominal aortic aneurysm.
    Kurosawa K, Matsumura JS, Yamanouchi D
    Circ. J. 2013; 77(12):2860-6.
    [PubMed ID: 24161907]
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  • Aneurysmal disease: the abdominal aorta.
    Takayama T, Yamanouchi D
    Surg. Clin. North Am. 2013 Aug; 93(4):877-91, viii.
    [PubMed ID: 23885935]
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  • The United States StuDy for EvalUating EndovasculaR TreAtments of Lesions in the Superficial Femoral Artery and Proximal Popliteal By usIng the Protégé EverfLex NitInol STent SYstem II (DURABILITY II).
    Matsumura JS, Yamanouchi D, Goldstein JA, Pollock CW, Bosiers M, Schultz GA, Scheinert D, Rocha-Singh KJ
    J. Vasc. Surg. 2013 Jul; 58(1):73-83.e1.
    [PubMed ID: 23642924]
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  • Balanced mineralization in the arterial system: possible role of osteoclastogenesis/osteoblastogenesis in abdominal aortic aneurysm and stenotic disease.
    Yamanouchi D, Takei Y, Komori K
    Circ. J. 2012; 76(12):2732-7.
    [PubMed ID: 23117745]
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  • Elevated protein kinase C-δ contributes to aneurysm pathogenesis through stimulation of apoptosis and inflammatory signaling.
    Morgan S, Yamanouchi D, Harberg C, Wang Q, Keller M, Si Y, Burlingham W, Seedial S, Lengfeld J, Liu B
    Arterioscler. Thromb. Vasc. Biol. 2012 Oct; 32(10):2493-502.
    [PubMed ID: 22879584, PMC ID: 3442600]
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  • Accelerated aneurysmal dilation associated with apoptosis and inflammation in a newly developed calcium phosphate rodent abdominal aortic aneurysm model.
    Yamanouchi D, Morgan S, Stair C, Seedial S, Lengfeld J, Kent KC, Liu B
    J. Vasc. Surg. 2012 Aug; 56(2):455-61.
    [PubMed ID: 22560311, PMC ID: 3408782]
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  • Transforming growth factor-β increases vascular smooth muscle cell proliferation through the Smad3 and extracellular signal-regulated kinase mitogen-activated protein kinases pathways.
    Suwanabol PA, Seedial SM, Shi X, Zhang F, Yamanouchi D, Roenneburg D, Liu B, Kent KC
    J. Vasc. Surg. 2012 Aug; 56(2):446-54.
    [PubMed ID: 22521802, PMC ID: 3408812]
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