Bo Liu, PhD

Professor

  • Division of Vascular Surgery

liub@surgery.wisc.edu
(608) 263-5931

Wisconsin Institutes for Medical Research (WIMR) BLDG. 1485
1111 Highland Avenue
Madison, WI 53705-2275

Education

  • MS, Biology, Beijing University, Beijing, China, 1986
  • PhD, Biochemistry, SUNY Downstate, New York, NY, 1993
  • Postdoctoral fellow, Signal transduction; protein degradation, Columbia University, New York, NY, 1994-1996
  • Postdoctoral fellow, Transcription regulation; signal transduction, Memorial Sloan-Kettering Cancer Center, New York, NY, 1996-1999

Research Interests

The primary focus of Dr. Liu’s research is the biology of blood vessels. Specifically, Dr. Liu and her trainees study the cellular and molecular pathologies of restenosis and abdominal aortic aneurysm, two common vascular disorders that are in critical need of effective pharmacological treatments. Their experimental approach combines in vitro molecular and biochemical methodologies with transgenic, gene knockout, adenoviral and surgical technologies. Current research topics include cell apoptosis, programmed necrosis, vascular inflammation, progenitor cell recruitment, as well as matrix biology. Additional research interests are gene therapy and nanotechnology. To effectively study human disease, Dr. Liu has established productive collaborations with basic scientists and clinicians from a wide range of scientific and medical disciplines. Dr. Liu is also a devoted mentor, whose lab environment fosters creative thinking, multidisciplinary approaches, independence, and collaboration.

Dr. Bo Liu’s Lab

Recent Publications

  • Deciphering Cell-Cell Communication in Abdominal Aortic Aneurysm From Single-Cell RNA Transcriptomic Data.
    Yang H, DeRoo E, Zhou T, Liu B
    Front Cardiovasc Med 2022; 9: 831789
    [PubMed ID: 35187133]

  • DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.
    Wang SB, Narendran S, Hirahara S, Varshney A, Pereira F, Apicella I, Ambati M, Ambati VL, Yerramothu P, Ambati K, Nagasaka Y, Argyle D, Huang P, Baker KL, Marion KM, Gupta K, Liu B, Hinton DR, Canna SW, Sallam T, Sadda SR, Kerur N, Gelfand BD, Ambati J
    Sci Immunol 2021 Dec 03; 6(66): eabi4493
    [PubMed ID: 34860583]

  • MLKL and CaMKII Are Involved in RIPK3-Mediated Smooth Muscle Cell Necroptosis.
    Zhou T, DeRoo E, Yang H, Stranz A, Wang Q, Ginnan R, Singer HA, Liu B
    Cells 2021 09 12; 10(9)
    [PubMed ID: 34572045]

  • Targeted Thrombospondin-1 Expression in Ocular Vascular Development and Neovascularization.
    Sorenson CM, Wang S, Darjatmoko SR, Gurel Z, Liu B, Sheibani N
    Front Cell Dev Biol 2021; 9: 671989
    [PubMed ID: 33968943]

  • Illuminating the Importance of Studying Interventions on the Propagation Phase of Experimental Mouse Abdominal Aortic Aneurysms.
    Lu HS, Owens AP, Liu B, Daugherty A
    Arterioscler Thromb Vasc Biol 2021 04; 41(4): 1518-1520
    [PubMed ID: 33760631]

All Publications on PubMed