Bo Liu, PhD
- Division of Vascular Surgery
Wisconsin Institutes for Medical Research (WIMR) BLDG. 1485
1111 Highland Avenue
Madison, WI 53705-2275
- MS, Biology, Beijing University, Beijing, China, 1986
- PhD, Biochemistry, SUNY Downstate, New York, NY, 1993
- Postdoctoral fellow, Signal transduction; protein degradation, Columbia University, New York, NY, 1994-1996
- Postdoctoral fellow, Transcription regulation; signal transduction, Memorial Sloan-Kettering Cancer Center, New York, NY, 1996-1999
The primary focus of Dr. Liu’s research is the biology of blood vessels. Specifically, Dr. Liu and her trainees study the cellular and molecular pathologies of restenosis and abdominal aortic aneurysm, two common vascular disorders that are in critical need of effective pharmacological treatments. Their experimental approach combines in vitro molecular and biochemical methodologies with transgenic, gene knockout, adenoviral and surgical technologies. Current research topics include cell apoptosis, programmed necrosis, vascular inflammation, progenitor cell recruitment, as well as matrix biology. Additional research interests are gene therapy and nanotechnology. To effectively study human disease, Dr. Liu has established productive collaborations with basic scientists and clinicians from a wide range of scientific and medical disciplines. Dr. Liu is also a devoted mentor, whose lab environment fosters creative thinking, multidisciplinary approaches, independence, and collaboration.
Stimuli-Responsive Polymer Coatings for the Rapid and Tunable Contact Transfer of Plasmid DNA to Soft Surfaces.
Appadoo V, Carter MCD, Jennings J, Guo X, Liu B, Hacker TA, Lynn DM
ACS Biomater Sci Eng 2022 Oct 10; 8(10): 4390-4401
[PubMed ID: 36130280]
pH-Responsive Polyelectrolyte Coatings that Enable Catheter-Mediated Transfer of DNA to the Arterial Wall in Short and Clinically Relevant Inflation Times.
Yu Y, Appadoo V, Ren J, Hacker TA, Liu B, Lynn DM
ACS Biomater Sci Eng 2022 Oct 10; 8(10): 4377-4389
[PubMed ID: 36121432]
Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL.
Gupta K, Brown KA, Hsieh ML, Hoover BM, Wang J, Khoury MK, Pilli VSS, Beyer RSH, Voruganti NR, Chaudhary S, Roberts DS, Murphy RM, Hong S, Ge Y, Liu B
J Extracell Vesicles 2022 Sep; 11(9): e12261
[PubMed ID: 36063142]
Deciphering Cell-Cell Communication in Abdominal Aortic Aneurysm From Single-Cell RNA Transcriptomic Data.
Yang H, DeRoo E, Zhou T, Liu B
Front Cardiovasc Med 2022; 9: 831789
[PubMed ID: 35187133]
DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.
Wang SB, Narendran S, Hirahara S, Varshney A, Pereira F, Apicella I, Ambati M, Ambati VL, Yerramothu P, Ambati K, Nagasaka Y, Argyle D, Huang P, Baker KL, Marion KM, Gupta K, Liu B, Hinton DR, Canna SW, Sallam T, Sadda SR, Kerur N, Gelfand BD, Ambati J
Sci Immunol 2021 Dec 03; 6(66): eabi4493
[PubMed ID: 34860583]