Luis Hidalgo, PhD, D(ABHI)
Associate Professor
- Histocompatibility Lab Director
- Division of Transplantation
hidalgo@surgery.wisc.edu
(608) 265-0428
HLA Lab
448 Science Drive
Madison WI 53711
Education
- PhD, Immunology, University of Alberta
- Diplomate - American Board of Histocompatibility and Immunogenetics
Research Interests
The focus of my research laboratory aims at elucidating the various mechanisms used by the human immune system to damage transplanted organs with specific focus on antibody-mediated rejection (ABMR). The immunologic understanding of ABMR that we have thus far identified points to a limited number of players. These players include donor-specific antibodies (DSA) (primarily targeting HLA), endothelial cell targets, and NK cell and monocyte effector cells working in concert to maximize their damage.
The laboratory’s projects are therefore split into two principal areas: immune effector cells in ABMR, and endothelial cell biology. The immune effector projects have a strong focus on assessing immune function of NK cells and monocytes particularly as it relates to activation through their Fc-gamma receptors. Endothelial cell studies relate to endothelial susceptibility to immune damage in ABMR and regulation of HLA surface expression. Findings within either of these areas have clinical implications as all of our studies are based on human immunology using primary cells. Our ultimate goal is to identify donor and recipient characteristics that define immunologic risk beyond the limited characteristics currently used.
Recent Publications
The Impact of HLA-DQαβ Heterodimer Mismatch on Living Donor Kidney Allograft Outcomes.
Charnaya O, Ishaque T, Hallett A, Morris GP, Coppage M, Schmitz JL, Timofeeva O, Lázár-Molnár E, Zhang A, Krummey S, Hidalgo L, Segev DL, Tambur AR, Massie AB
Transplantation 2024 Sep 05;
[PubMed ID: 39233325]Chronic Rejection After Kidney Transplantation.
Diebold M, Mayer KA, Hidalgo L, Kozakowski N, Budde K, Böhmig GA
Transplantation 2024 Aug 28;
[PubMed ID: 39192468]Natural Killer Cell Presence in Antibody-Mediated Rejection.
Diebold M, Farkash EA, Barnes J, Regele H, Kozakowski N, Schatzl M, Mayer KA, Haindl S, Vietzen H, Hidalgo LG, Halloran PF, Eskandary F, Böhmig GA
Transpl Int 2024; 37: 13209
[PubMed ID: 38979120]Novel Tools for the Study of HLA Class II Cross-isotype Pairings.
Hidalgo LG
Transplantation 2024 May 01; 108(5): 1058-1059
[PubMed ID: 38659116]Islet transplantation outcomes in type 1 diabetes and transplantation of HLA-DQ8/DR4: results of a single-centre retrospective cohort in Canada.
Forbes S, Halpin A, Lam A, Grynoch D, Parker R, Hidalgo L, Bigam D, Anderson B, Dajani K, Kin T, O'Gorman D, Senior PA, Campbell P, Shapiro AMJ
EClinicalMedicine 2024 Jan; 67: 102333
[PubMed ID: 38169703]