Education

• MD, Gunma University, Japan, 2000
• PhD, Gunma University, Japan, 2006
• Surgical Internship and Residency, Gunma University Hospital, Japan, 2000-2003
• Surgical Residency, Saiseikai Maebashi Hospital, Japan, 2001-2002
• Research Fellowship, Nagoya University Graduate School of Medicine, Japan, 2003-2004
• Clinical Fellowship in Vascular Surgery, Nagoya University Hospital, Japan, 2004-2007
• Research Fellowship, Weill Cornell Medical College, New York, NY, 2007-2008
• Fellowship in Advanced Endovascular Surgery, University of Wisconsin Madison, Madison, WI, 2009-2010

Clinical Specialties

Dr. Yamanouchi specializes in vascular and endovascular surgery. He is board certified in surgery in Japan.

Dr. Yamanouchi provides a wide range of services including Adbominal Aortic Aneurysm (AAA) Repair – Endovascular, Adbominal Aortic Aneurysm (AAA) Repair – Open, Amputation, Angioplasty With Stent Placement, Carotid Endartecotomy, Peripheral Artery Bypass, Thoracic Aortic Aneursym – Endovascular, Thoracic Outlet Syndrome Treatment, and Varicose Vein Treatment.

Dr. Yamanouchi provides a wide range of services including Adbominal Aortic Aneurysm (AAA) Repair - Endovascular, Adbominal Aortic Aneurysm (AAA) Repair - Open, Amputation, Angioplasty With Stent Placement, Carotid Endartecotomy, Carotid Stenting, Peripheral Artery Bypass, Thoracic Aortic Aneursym - Endovascular, Thoracic Aortic Aneursym - Open, Thoracic Outlet Syndrome Treatment, and Varicose Vein Treatment.

Research Interests

Dr. Yamanouchi’s research interests include the pathogenesis of abdominal aortic aneurysm and restenosis after angioplasty including balloon angioplasty and stent placement. He is also devoted to the development of novel materials for vascular bypass graft and gene delivery method to treat the patients who suffers peripheral arterial disease.

Dr. Yamanouchi's Lab

Funding/Grants

• The Role of Osteoclastogenesis in Abdominal Aortic Aneurym
  Funding Agency: American Heart Association
  Principal Investigator(s): Dai Yamanouchi, MD, PhD
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Recent Publications

• Accelerated aneurysmal dilation associated with apoptosis and inflammation in a newly developed calcium phosphate rodent abdominal aortic aneurysm model.
  Yamanouchi D, Morgan S, Stair C, Seedial S, Lengfeld J, Kent KC, Liu B
  Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 2012 May 4.
  [PubMed ID: 22560311]
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• Transforming growth factor-β increases vascular smooth muscle cell proliferation through the Smad3 and extracellular signal-regulated kinase mitogen-activated protein kinases pathways.
  Suwanabol PA, Seedial SM, Shi X, Zhang F, Yamanouchi D, Roenneburg D, Liu B, Kent KC
  Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 2012 Apr 20.
  [PubMed ID: 22521802]
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• Results of carotid artery stenting with distal embolic protection with improved systems: Protected Carotid Artery Stenting in Patients at High Risk for Carotid Endarterectomy (PROTECT) trial.
  Matsumura JS, Gray W, Chaturvedi S, Yamanouchi D, Peng L, Verta P
  J. Vasc. Surg. 2012 Apr; 55(4):968-976.e5.
  [PubMed ID: 22236885]
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• Delivery of plasmid DNA to vascular tissue in vivo using catheter balloons coated with polyelectrolyte multilayers.
  Saurer EM, Yamanouchi D, Liu B, Lynn DM
  Biomaterials 2011 Jan; 32(2):610-8.
  [PubMed ID: 20933275, PMC ID: 2991550]
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• Eicosapentaenoic acid as the gold standard for patients with peripheral artery disease? - subanalysis of the JELIS trial -.
  Yamanouchi D, Komori K
  Circ. J. 2010 Jul; 74(7):1298-9.
  [PubMed ID: 20558888]
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• The novel function of advanced glycation end products in regulation of MMP-9 production.
  Zhang F, Banker G, Liu X, Suwanabol PA, Lengfeld J, Yamanouchi D, Kent KC, Liu B
  J. Surg. Res. 2011 Dec; 171(2):871-6.
  [PubMed ID: 20638679]
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• Effects of caspase inhibitor on angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice.
  Yamanouchi D, Morgan S, Kato K, Lengfeld J, Zhang F, Liu B
  Arterioscler. Thromb. Vasc. Biol. 2010 Apr; 30(4):702-7.
  [PubMed ID: 20075419]
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• Caspase-mediated protein kinase C-delta cleavage is necessary for apoptosis of vascular smooth muscle cells.
  Kato K, Yamanouchi D, Esbona K, Kamiya K, Zhang F, Kent KC, Liu B
  Am. J. Physiol. Heart Circ. Physiol. 2009 Dec; 297(6):H2253-61.
  [PubMed ID: 19837952, PMC ID: 2793135]
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• Protein kinase C delta mediates arterial injury responses through regulation of vascular smooth muscle cell apoptosis.
  Yamanouchi D, Kato K, Ryer EJ, Zhang F, Liu B
  Cardiovasc. Res. 2010 Feb 1; 85(3):434-43.
  [PubMed ID: 19808702, PMC ID: 2860709]
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• Anti-receptor for advanced glycation end products therapies as novel treatment for abdominal aortic aneurysm.
  Zhang F, Kent KC, Yamanouchi D, Zhang Y, Kato K, Tsai S, Nowygrod R, Schmidt AM, Liu B
  Ann. Surg. 2009 Sep; 250(3):416-23.
  [PubMed ID: 19652591, PMC ID: 2921961]
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