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Lee G Wilke, MD, FACS

Surgical Services

Contact Dr. Wilke


(608) 265-5852

600 Highland Avenue
Madison, WI 53792

Lee G Wilke, MD, FACS

Interim Chief, Section of General Surgery
Director, UW Breast Center
Division of Surgical Oncology


  • MD, Duke University, Durham, NC, 1993
  • Residency in Surgery, University of Michigan, Ann Arbor, Michigan, 1993-2000
  • ACS Resident Research Fellow in Immunotherapy, University of Michigan, Ann Arbor, MI 1996-1998

Clinical Specialties

Dr. Wilke is certified by the American Board of Surgery and specializes in benign and malignant diseases of the breast; sentinel lymph-node mapping; neoadjuvant therapy for breast cancer; and oncoplastic breast surgery.

Dr. Wilke provides a wide range of services including Axillary Lymph Node Dissection, Core Needle Biopsy, Lumpectomy or Partial Mastectomy, Modified Radical Mastectomy, Needle-localized Biopsy, Needle-localized Excision, Sentinel Lymph Node Biopsy, Simple Mastectomy, and Skin-sparing and/or Nipple-sparing Mastectomy.

Research Interests

Dr. Wilke’s principal research interest is clinical trials seeking novel methods of treating patients with breast cancer. Dr. Wilke is a member of the Commission on Cancer. She is also a collaborator on multiple grants and trials evaluating novel treatments for breast cancer.

Active Clinical Trials

Recent Publications
  • Oncologists' perceived barriers to an expanded role for primary care in breast cancer survivorship care.
    Neuman HB, Jacobs EA, Steffens NM, Jacobson N, Tevaarwerk A, Wilke LG, Tucholka J, Greenberg CC
    Cancer Med 2016 Jun 30.
    [PubMed ID: 27356781]
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  • Current Trends in the Management of Phyllodes Tumors of the Breast.
    Adesoye T, Neuman HB, Wilke LG, Schumacher JR, Steiman J, Greenberg CC
    Ann. Surg. Oncol. 2016 Jun 22.
    [PubMed ID: 27334214]
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  • Identification and Resection of Clipped Node Decreases the False-negative Rate of Sentinel Lymph Node Surgery in Patients Presenting With Node-positive Breast Cancer (T0-T4, N1-N2) Who Receive Neoadjuvant Chemotherapy: Results From ACOSOG Z1071 (Alliance).
    Boughey JC, Ballman KV, Le-Petross HT, McCall LM, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B, Feliberti EC, Hunt KK
    Ann. Surg. 2016 Apr; 263(4):802-7.
    [PubMed ID: 26649589, PMC ID: 4777661]
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  • The Role of Intraoperative Pathologic Assessment in the Surgical Management of Ductal Carcinoma In Situ.
    Decker MR, Trentham-Dietz A, Loconte NK, Neuman HB, Smith MA, Punglia RS, Greenberg CC, Wilke LG
    Ann. Surg. Oncol. 2016 Mar 29.
    [PubMed ID: 27026436]
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  • Dissemination and implementation: Translating cancer guidelines and clinical trial outcomes into everyday practice.
    Wilke LG, Dickson-Witmer D, Boughey JC
    Bull Am Coll Surg 2016 Feb; 101(2):33-4.
    [PubMed ID: 26995861]
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  • Analysis of Immune Cells from Human Mammary Ductal Epithelial Organoids Reveals Vδ2+ T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate.
    Zumwalde NA, Haag JD, Sharma D, Mirrielees JA, Wilke LG, Gould MN, Gumperz JE
    Cancer Prev Res (Phila) 2016 Apr; 9(4):305-16.
    [PubMed ID: 26811335, PMC ID: 4818696]
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  • Breast Cancer Survivor Advocacy at a University Hospital: Development of a Peer Support Program with Evaluation by Patients, Advocates, and Clinicians.
    Mirrielees JA, Breckheimer KR, White TA, Denure DA, Schroeder MM, Gaines ME, Wilke LG, Tevaarwerk AJ
    J Cancer Educ 2015 Oct 19.
    [PubMed ID: 26477478, PMC ID: 4837082]
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  • Oncologists' Perspectives of Their Roles and Responsibilities During Multi-disciplinary Breast Cancer Follow-Up.
    Neuman HB, Steffens NM, Jacobson N, Tevaarwerk A, Anderson B, Wilke LG, Greenberg CC
    Ann. Surg. Oncol. 2016 Mar; 23(3):708-14.
    [PubMed ID: 26474556, PMC ID: 4749446]
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  • Correction: differential CARM1 isoform expression in subcellular compartments and among malignant and benign breast tumors.
    Shlensky D, Mirrielees JA, Zhao Z, Wang L, Mahajan A, Yu M, Sherer NM, Wilke LG, Xu W
    PLoS ONE 2015; 10(6):e0131955.
    [PubMed ID: 26110850, PMC ID: 4482405]
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  • A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins.
    Nichols BS, Schindler CE, Brown JQ, Wilke LG, Mulvey CS, Krieger MS, Gallagher J, Geradts J, Greenup RA, Von Windheim JA, Ramanujam N
    PLoS ONE 2015; 10(6):e0127525.
    [PubMed ID: 26076123, PMC ID: 4468201]
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