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Lee G Wilke, MD, FACS

Surgical Services

Contact Dr. Wilke


(608) 263-1387

600 Highland Avenue
Madison, WI 53792

Lee G Wilke, MD, FACS

Interim Chief, Section of General Surgery
Director, UW Breast Center
Division of Surgical Oncology


  • MD, Duke University, Durham, NC, 1993
  • Residency in Surgery, University of Michigan, Ann Arbor, Michigan, 1993-2000
  • ACS Resident Research Fellow in Immunotherapy, University of Michigan, Ann Arbor, MI 1996-1998

Clinical Specialties

Dr. Wilke is certified by the American Board of Surgery and specializes in benign and malignant diseases of the breast; sentinel lymph-node mapping; neoadjuvant therapy for breast cancer; and oncoplastic breast surgery.

Dr. Wilke provides a wide range of services including Axillary Lymph Node Dissection, Core Needle Biopsy, Lumpectomy or Partial Mastectomy, Modified Radical Mastectomy, Needle-localized Biopsy, Needle-localized Excision, Sentinel Lymph Node Biopsy, Simple Mastectomy, and Skin-sparing and/or Nipple-sparing Mastectomy.

Research Interests

Dr. Wilke’s principal research interest is clinical trials seeking novel methods of treating patients with breast cancer. Dr. Wilke is a member of the Commission on Cancer. She is also a collaborator on multiple grants and trials evaluating novel treatments for breast cancer.

Active Clinical Trials

Recent Publications
  • Breast Cancer Survivor Advocacy at a University Hospital: Development of a Peer Support Program with Evaluation by Patients, Advocates, and Clinicians.
    Mirrielees JA, Breckheimer KR, White TA, Denure DA, Schroeder MM, Gaines ME, Wilke LG, Tevaarwerk AJ
    J Cancer Educ 2015 Oct 19.
    [PubMed ID: 26477478]
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  • Oncologists' Perspectives of Their Roles and Responsibilities During Multi-disciplinary Breast Cancer Follow-Up.
    Neuman HB, Steffens NM, Jacobson N, Tevaarwerk A, Anderson B, Wilke LG, Greenberg CC
    Ann. Surg. Oncol. 2015 Oct 16.
    [PubMed ID: 26474556]
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  • Correction: differential CARM1 isoform expression in subcellular compartments and among malignant and benign breast tumors.
    Shlensky D, Mirrielees JA, Zhao Z, Wang L, Mahajan A, Yu M, Sherer NM, Wilke LG, Xu W
    PLoS ONE 2015; 10(6):e0131955.
    [PubMed ID: 26110850, PMC ID: 4482405]
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  • A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins.
    Nichols BS, Schindler CE, Brown JQ, Wilke LG, Mulvey CS, Krieger MS, Gallagher J, Geradts J, Greenup RA, Von Windheim JA, Ramanujam N
    PLoS ONE 2015; 10(6):e0127525.
    [PubMed ID: 26076123, PMC ID: 4468201]
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  • Differential CARM1 Isoform Expression in Subcellular Compartments and among Malignant and Benign Breast Tumors.
    Shlensky D, Mirrielees JA, Zhao Z, Wang L, Mahajan A, Yu M, Sherer NM, Wilke LG, Xu W
    PLoS ONE 2015; 10(6):e0128143.
    [PubMed ID: 26030442, PMC ID: 4451767]
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  • Factors affecting sentinel lymph node identification rate after neoadjuvant chemotherapy for breast cancer patients enrolled in ACOSOG Z1071 (Alliance).
    Boughey JC, Suman VJ, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B, Leitch AM, Flippo-Morton TS, Kuerer HM, Bowling M, Hunt KK, Alliance for Clinical Trials in Oncology
    Ann. Surg. 2015 Mar; 261(3):547-52.
    [PubMed ID: 25664534, PMC ID: 4324533]
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  • Axillary Ultrasound After Neoadjuvant Chemotherapy and Its Impact on Sentinel Lymph Node Surgery: Results From the American College of Surgeons Oncology Group Z1071 Trial (Alliance).
    Boughey JC, Ballman KV, Hunt KK, McCall LM, Mittendorf EA, Ahrendt GM, Wilke LG, Le-Petross HT
    J. Clin. Oncol. 2015 Oct 20; 33(30):3386-93.
    [PubMed ID: 25646192, PMC ID: 4606058]
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  • Repeat surgery after breast conservation for the treatment of stage 0 to II breast carcinoma: a report from the National Cancer Data Base, 2004-2010.
    Wilke LG, Czechura T, Wang C, Lapin B, Liederbach E, Winchester DP, Yao K
    JAMA Surg 2014 Dec; 149(12):1296-305.
    [PubMed ID: 25390819]
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  • Tumor biology correlates with rates of breast-conserving surgery and pathologic complete response after neoadjuvant chemotherapy for breast cancer: findings from the ACOSOG Z1071 (Alliance) Prospective Multicenter Clinical Trial.
    Boughey JC, McCall LM, Ballman KV, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B, Leitch AM, Flippo-Morton T, Hunt KK
    Ann. Surg. 2014 Oct; 260(4):608-14; discussion 614-6.
    [PubMed ID: 25203877, PMC ID: 4159769]
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  • Commentary on the Canadian National Breast Screening study.
    Van Zee KJ, Hansen NM, Barrio AV, Connor CS, Danforth DN, Euhus DM, Kulkarni SA, McCready DR, McLaughlin S, Wilke LG
    Ann. Surg. Oncol. 2014 Dec; 21(13):4397-8.
    [PubMed ID: 24859935]
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