Education

• MD, Duke University, Durham, NC, 1993
• Residency in Surgery, University of Michigan, Ann Arbor, Michigan, 1993-2000
• ACS Resident Research Fellow in Immunotherapy, University of Michigan, Ann Arbor, MI 1996-1998

Clinical Specialties

Dr. Wilke is certified by the American Board of Surgery and specializes in benign and malignant diseases of the breast; sentinel lymph-node mapping; neoadjuvant therapy for breast cancer; and laparoscopic abdominal surgery.

Dr. Wilke provides a wide range of services including Axillary Lymph Node Dissection, Core Needle Biopsy, Lumpectomy or Partial Mastectomy, Modified Radical Mastectomy, Needle-localized Biopsy, Needle-localized Excision, Sentinel Lymph Node Biopsy, Simple Mastectomy, and Skin-sparing and/or Nipple-sparing Mastectomy.

Research Interests

Dr. Wilke’s principal research interest is clinical trials seeking novel methods of treating patients with breast cancer. Dr. Wilke is a member of the executive committee of the American College of Surgeons Oncology Group. She is also a collaborator and investigator evaluating the use of optical spectroscopy to evaluate breast tumor margins and aid in the diagnosis and evaluation of solid tumors.

Recent Publications

• Impact of axillary ultrasound and core needle biopsy on the utility of intraoperative frozen section analysis and treatment decision making in women with invasive breast cancer.
  Caretta-Weyer H, Sisney GA, Beckman C, Burnside ES, Salkowsi LR, Strigel RM, Wilke LG, Neuman HB
  American journal of surgery 2012 Apr 6.
  [PubMed ID: 22483606]
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• Survival analysis of cancer risk reduction strategies for BRCA1/2 mutation carriers.
  Latosinsky S, Cheifetz RE, Wilke LG,
  J. Am. Coll. Surg. 2011 Sep; 213(3):447-50.
  [PubMed ID: 21871383]
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• Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways.
  Ibarra-Drendall C, Troch MM, Barry WT, Broadwater G, Petricoin EF, Wulfkuhle J, Liotta LA, Lem S, Baker JC, Ford AC, Wilke LG, Zalles C, Kuderer NM, Hoffman AW, Shivraj M, Mehta P, Williams J, Tolbert N, Lee LW, Pilie PG, Yu D, Seewaldt VL
  Breast Cancer Res. Treat. 2012 Apr; 132(2):487-98.
  [PubMed ID: 21647677]
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• Protein microarray analysis of mammary epithelial cells from obese and nonobese women at high risk for breast cancer: feasibility data.
  Pilie PG, Ibarra-Drendall C, Troch MM, Broadwater G, Barry WT, Petricoin EF, Wulfkuhle JD, Liotta LA, Lem S, Baker JC, Stouder A, Ford AC, Wilke LG, Zalles CM, Mehta P, Williams J, Shivraj M, Su Z, Geradts J, Yu D, Seewaldt VL
  Cancer Epidemiol. Biomarkers Prev. 2011 Mar; 20(3):476-82.
  [PubMed ID: 21242333, PMC ID: 3051011]
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• Early results from a novel quality outcomes program: the American Society Of Breast Surgeons' Mastery of Breast Surgery.
  Clifford EJ, De Vol EB, Pockaj BA, Wilke LG, Boughey JC
  Ann. Surg. Oncol. 2010 Oct; 17 Suppl 3():233-41.
  [PubMed ID: 20853039]
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• Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins.
  Bydlon TM, Kennedy SA, Richards LM, Brown JQ, Yu B, Junker MK, Gallagher J, Geradts J, Wilke LG, Ramanujam N
  Opt Express 2010 Apr 12; 18(8):8058-76.
  [PubMed ID: 20588651, PMC ID: 2939901]
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• Adherence to the National Quality Forum (NQF) breast cancer measures within cancer clinical trials: a review from ACOSOG Z0010.
  Wilke LG, Ballman KV, McCall LM, Giuliano AE, Whitworth PW, Blumencranz PW, Reintgen DS, Burak WE, Leitch AM, Hunt KK
  Ann. Surg. Oncol. 2010 Aug; 17(8):1989-94.
  [PubMed ID: 20309640, PMC ID: 2950006]
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• Promoting patient safety through peer review.
  Wilke LG, Nelson H, Ota DM
  Bull Am Coll Surg 2010 Mar; 95(3):45-6.
  [PubMed ID: 21456407]
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• Breast self-examination: defining a cohort still in need.
  Wilke LG, Broadwater G, Rabiner S, Owens E, Yoon S, Ghate S, Scott V, Walsh R, Baker J, Soo MS, Ibarra-Drendall C, Stouder A, Robertson S, Barron A, Seewaldt V
  Am. J. Surg. 2009 Oct; 198(4):575-9.
  [PubMed ID: 19800471]
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• Rapid noninvasive optical imaging of tissue composition in breast tumor margins.
  Wilke LG, Brown JQ, Bydlon TM, Kennedy SA, Richards LM, Junker MK, Gallagher J, Barry WT, Geradts J, Ramanujam N
  Am. J. Surg. 2009 Oct; 198(4):566-74.
  [PubMed ID: 19800470, PMC ID: 2764289]
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