Skip to Content
Lee G Wilke, MD, FACS

Surgical Services

Contact Dr. Wilke


(608) 265-5852

600 Highland Avenue
Madison, WI 53792

Lee G Wilke, MD, FACS

Director, UW Breast Center
Section of Surgical Oncology
Division of General Surgery


  • MD, Duke University, Durham, NC, 1993
  • Residency in Surgery, University of Michigan, Ann Arbor, Michigan, 1993-2000
  • ACS Resident Research Fellow in Immunotherapy, University of Michigan, Ann Arbor, MI 1996-1998

Clinical Specialties

Dr. Wilke is certified by the American Board of Surgery and specializes in benign and malignant diseases of the breast; sentinel lymph-node mapping; neoadjuvant therapy for breast cancer; and oncoplastic breast surgery.

Dr. Wilke provides a wide range of services including Axillary Lymph Node Dissection, Core Needle Biopsy, Lumpectomy or Partial Mastectomy, Modified Radical Mastectomy, Needle-localized Biopsy, Needle-localized Excision, Sentinel Lymph Node Biopsy, Simple Mastectomy, and Skin-sparing and/or Nipple-sparing Mastectomy.

Research Interests

Dr. Wilke’s principal research interest is clinical trials seeking novel methods of treating patients with breast cancer. Dr. Wilke is a member of the Commission on Cancer. She is also a collaborator on multiple grants and trials evaluating novel treatments for breast cancer.

Recent Publications
  • Repeat Surgery After Breast Conservation for the Treatment of Stage 0 to II Breast Carcinoma: A Report From the National Cancer Data Base, 2004-2010.
    Wilke LG, Czechura T, Wang C, Lapin B, Liederbach E, Winchester DP, Yao K
    JAMA Surg 2014 Dec 1; 149(12):1296-305.
    [PubMed ID: 25390819]
    More Information
  • Tumor biology correlates with rates of breast-conserving surgery and pathologic complete response after neoadjuvant chemotherapy for breast cancer: findings from the ACOSOG Z1071 (Alliance) Prospective Multicenter Clinical Trial.
    Boughey JC, McCall LM, Ballman KV, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B, Leitch AM, Flippo-Morton T, Hunt KK
    Ann. Surg. 2014 Oct; 260(4):608-14; discussion 614-6.
    [PubMed ID: 25203877, PMC ID: 4159769]
    More Information
  • Commentary on the Canadian National Breast Screening study.
    Van Zee KJ, Hansen NM, Barrio AV, Connor CS, Danforth DN, Euhus DM, Kulkarni SA, McCready DR, McLaughlin S, Wilke LG
    Ann. Surg. Oncol. 2014 Dec; 21(13):4397-8.
    [PubMed ID: 24859935]
    More Information
  • Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles.
    Zasadil LM, Andersen KA, Yeum D, Rocque GB, Wilke LG, Tevaarwerk AJ, Raines RT, Burkard ME, Weaver BA
    Sci Transl Med 2014 Mar 26; 6(229):229ra43.
    [PubMed ID: 24670687, PMC ID: 4176609]
    More Information
  • Metastasis of primary lung carcinoma to the breast: a systematic review of the literature.
    Mirrielees JA, Kapur JH, Szalkucki LM, Harter JM, Salkowski LR, Strigel RM, Traynor AM, Wilke LG
    J. Surg. Res. 2014 May 15; 188(2):419-31.
    [PubMed ID: 24560348]
    More Information
  • Impact of the American College of Surgeons Oncology Group (ACOSOG) Z0011 trial on clinical management of the axilla in older breast cancer patients: a SEER-medicare analysis.
    Caretta-Weyer H, Greenberg CG, Wilke LG, Weiss J, LoConte NK, Decker M, Steffens NM, Smith MA, Neuman HB
    Ann. Surg. Oncol. 2013 Dec; 20(13):4145-52.
    [PubMed ID: 23959051, PMC ID: 3874252]
    More Information
  • Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial.
    Boughey JC, Suman VJ, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B, Leitch AM, Kuerer HM, Bowling M, Flippo-Morton TS, Byrd DR, Ollila DW, Julian TB, McLaughlin SA, McCall L, Symmans WF, Le-Petross HT, Haffty BG, Buchholz TA, Nelson H, Hunt KK, Alliance for Clinical Trials in Oncology
    JAMA 2013 Oct 9; 310(14):1455-61.
    [PubMed ID: 24101169, PMC ID: 4075763]
    More Information
  • Safety and efficacy of aerobic training in operable breast cancer patients receiving neoadjuvant chemotherapy: a phase II randomized trial.
    Hornsby WE, Douglas PS, West MJ, Kenjale AA, Lane AR, Schwitzer ER, Ray KA, Herndon JE, Coan A, Gutierrez A, Hornsby KP, Hamilton E, Wilke LG, Kimmick GG, Peppercorn JM, Jones LW
    Acta Oncol 2014 Jan; 53(1):65-74.
    [PubMed ID: 23957716]
    More Information
  • Optical spectral surveillance of breast tissue landscapes for detection of residual disease in breast tumor margins.
    Brown JQ, Bydlon TM, Kennedy SA, Caldwell ML, Gallagher JE, Junker M, Wilke LG, Barry WT, Geradts J, Ramanujam N
    PLoS ONE 2013; 8(7):e69906.
    [PubMed ID: 23922850, PMC ID: 3724737]
    More Information
  • Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy.
    Jones LW, Fels DR, West M, Allen JD, Broadwater G, Barry WT, Wilke LG, Masko E, Douglas PS, Dash RC, Povsic TJ, Peppercorn J, Marcom PK, Blackwell KL, Kimmick G, Turkington TG, Dewhirst MW
    Cancer Prev Res (Phila) 2013 Sep; 6(9):925-37.
    [PubMed ID: 23842792, PMC ID: 3800005]
    More Information Copyright © 2015 The Board of Regents of the University of Wisconsin System