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Lee G Wilke, MD, FACS

Surgical Services

Contact Dr. Wilke


(608) 265-5852

600 Highland Avenue
Madison, WI 53792

Lee G Wilke, MD, FACS

Interim Chief, Section of General Surgery
Director, UW Breast Center
Division of Surgical Oncology


  • MD, Duke University, Durham, NC, 1993
  • Residency in Surgery, University of Michigan, Ann Arbor, Michigan, 1993-2000
  • ACS Resident Research Fellow in Immunotherapy, University of Michigan, Ann Arbor, MI 1996-1998

Clinical Specialties

Dr. Wilke is certified by the American Board of Surgery and specializes in benign and malignant diseases of the breast; sentinel lymph-node mapping; neoadjuvant therapy for breast cancer; and oncoplastic breast surgery.

Dr. Wilke provides a wide range of services including Axillary Lymph Node Dissection, Core Needle Biopsy, Lumpectomy or Partial Mastectomy, Modified Radical Mastectomy, Needle-localized Biopsy, Needle-localized Excision, Sentinel Lymph Node Biopsy, Simple Mastectomy, and Skin-sparing and/or Nipple-sparing Mastectomy.

Research Interests

Dr. Wilke’s principal research interest is clinical trials seeking novel methods of treating patients with breast cancer. Dr. Wilke is a member of the Commission on Cancer. She is also a collaborator on multiple grants and trials evaluating novel treatments for breast cancer.

Active Clinical Trials

Recent Publications
  • Contralateral Prophylactic Mastectomy Consensus Statement from the American Society of Breast Surgeons: Additional Considerations and a Framework for Shared Decision Making.
    Boughey JC, Attai DJ, Chen SL, Cody HS, Dietz JR, Feldman SM, Greenberg CC, Kass RB, Landercasper J, Lemaine V, MacNeill F, Margenthaler JA, Song DH, Staley AC, Wilke LG, Willey SC, Yao KA
    Ann. Surg. Oncol. 2016 Jul 28.
    [PubMed ID: 27469118]
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  • Contralateral Prophylactic Mastectomy (CPM) Consensus Statement from the American Society of Breast Surgeons: Data on CPM Outcomes and Risks.
    Boughey JC, Attai DJ, Chen SL, Cody HS, Dietz JR, Feldman SM, Greenberg CC, Kass RB, Landercasper J, Lemaine V, MacNeill F, Song DH, Staley AC, Wilke LG, Willey SC, Yao KA, Margenthaler JA
    Ann. Surg. Oncol. 2016 Jul 28.
    [PubMed ID: 27469117]
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  • Oncologists' perceived barriers to an expanded role for primary care in breast cancer survivorship care.
    Neuman HB, Jacobs EA, Steffens NM, Jacobson N, Tevaarwerk A, Wilke LG, Tucholka J, Greenberg CC
    Cancer Med 2016 Jun 30.
    [PubMed ID: 27356781]
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  • Current Trends in the Management of Phyllodes Tumors of the Breast.
    Adesoye T, Neuman HB, Wilke LG, Schumacher JR, Steiman J, Greenberg CC
    Ann. Surg. Oncol. 2016 Jun 22.
    [PubMed ID: 27334214]
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  • Correlation of breast tissue histology and optical signatures to improve margin assessment techniques.
    Kennedy S, Caldwell M, Bydlon T, Mulvey C, Mueller J, Wilke L, Barry W, Ramanujam N, Geradts J
    J Biomed Opt 2016 Jun 1; 21(6):66014.
    [PubMed ID: 27327487, PMC ID: 4914603]
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  • Identification and Resection of Clipped Node Decreases the False-negative Rate of Sentinel Lymph Node Surgery in Patients Presenting With Node-positive Breast Cancer (T0-T4, N1-N2) Who Receive Neoadjuvant Chemotherapy: Results From ACOSOG Z1071 (Alliance).
    Boughey JC, Ballman KV, Le-Petross HT, McCall LM, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B, Feliberti EC, Hunt KK
    Ann. Surg. 2016 Apr; 263(4):802-7.
    [PubMed ID: 26649589, PMC ID: 4777661]
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  • The Role of Intraoperative Pathologic Assessment in the Surgical Management of Ductal Carcinoma In Situ.
    Decker MR, Trentham-Dietz A, Loconte NK, Neuman HB, Smith MA, Punglia RS, Greenberg CC, Wilke LG
    Ann. Surg. Oncol. 2016 Sep; 23(9):2788-94.
    [PubMed ID: 27026436, PMC ID: 4974137]
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  • COX-2 modulates mammary tumor progression in response to collagen density.
    Esbona K, Inman D, Saha S, Jeffery J, Schedin P, Wilke L, Keely P
    Breast Cancer Res. 2016; 18(1):35.
    [PubMed ID: 27000374, PMC ID: 4802888]
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  • Dissemination and implementation: Translating cancer guidelines and clinical trial outcomes into everyday practice.
    Wilke LG, Dickson-Witmer D, Boughey JC
    Bull Am Coll Surg 2016 Feb; 101(2):33-4.
    [PubMed ID: 26995861]
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  • Analysis of Immune Cells from Human Mammary Ductal Epithelial Organoids Reveals Vδ2+ T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate.
    Zumwalde NA, Haag JD, Sharma D, Mirrielees JA, Wilke LG, Gould MN, Gumperz JE
    Cancer Prev Res (Phila) 2016 Apr; 9(4):305-16.
    [PubMed ID: 26811335, PMC ID: 4818696]
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