Lee G Wilke, MD, FACS


  • Senior Medical Director, Clinical Cancer Services; UW Health/UW Carbone Cancer Center
  • Associate Director, Clinical Research; UW Carbone Cancer Center
  • Professor, Division of Surgical Oncology
  • Hendricks Chair in Breast Cancer Surgery Research
  • Vice Chair of Research; UW Department of Surgery

(608) 263-7064

  • Administrative Assistant: (608) 262-2025

600 Highland Avenue
Box 7375 Clinical Science Center
Madison, WI 53792


  • MD, Duke University, Durham, NC, 1993
  • Residency in Surgery, University of Michigan, Ann Arbor, Michigan, 1993-2000
  • ACS Resident Research Fellow in Immunotherapy, University of Michigan, Ann Arbor, MI 1996-1998

Clinical Specialties

Dr. Wilke is certified by the American Board of Surgery and specializes in benign and malignant diseases of the breast; sentinel lymph-node mapping; neoadjuvant therapy for breast cancer; and oncoplastic breast surgery.

Research Interests

Dr. Wilke’s principal research interest is in clinical trials seeking novel methods of treating patients with breast cancer. Dr. Wilke is lead Principal investigator for the UW Carbone Cancer Center NCTN Lead Academic Program UG1 Grant, is Research Chair for the American Society of Breast Surgeons and a Board member for the NCCN and NAPBC. She is a collaborator on multiple grants and trials evaluating novel medical and surgical treatments for breast cancer.

Recent Publications

  • Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer.
    Hu Y, Manasrah BK, McGregor SM, Lera RF, Norman RX, Tucker JB, Scribano CM, Yan RE, Humayun M, Wisinski KB, Tevaarwerk AJ, O'Regan RM, Wilke LG, Weaver BA, Beebe DJ, Jin N, Burkard ME
    Mol Cancer Ther 2021 12; 20(12): 2553-2567
    [PubMed ID: 34583980]

  • Creating a healthy community after the pandemic: Reinvigorating routine cancer screening with community support systems.
    Wilke LG
    Cancer 2021 12 01; 127(23): 4365-4367
    [PubMed ID: 34436764]

  • Analysis of the Impact of the COVID-19 Pandemic on the Multidisciplinary Management of Breast Cancer: Review from the American Society of Breast Surgeons COVID-19 and Mastery Registries.
    Wilke LG, Nguyen TT, Yang Q, Hanlon BM, Wagner KA, Strickland P, Brown E, Dietz JR, Boughey JC
    Ann Surg Oncol 2021 Oct; 28(10): 5535-5543
    [PubMed ID: 34431019]

  • ASO Authors Reflection: Lessons Learned from the COVID-19 Pandemic-Should We Change Surgical Management of Patients with Breast Cancer?
    Boughey JC, Nguyen TT, Dietz JR, Wilke LG
    Ann Surg Oncol 2021 Aug 11;
    [PubMed ID: 34379253]

  • The Impact of Radiotherapy Delay in Breast Conservation Patients Not Receiving Chemotherapy and the Rationale for Dichotomizing the Radiation Oncology Time-Dependent Standard into Two Quality Measures.
    Bleicher RJ, Moran MS, Ruth K, Edge SB, Dietz JM, Wilke LG, Stearns V, Kurtzman SH, Klein J, Yao KA
    Ann Surg Oncol 2022 Jan; 29(1): 469-481
    [PubMed ID: 34324114]

All Publications on PubMed