Sharon M Weber, MD, FACS
Professor
- Chair, Division of Surgical Oncology
- Medical Director of Surgical Oncology, UW Carbone Cancer Center
- Endowed Professor, Tim and Mary Ann McKenzie Professorship in Surgical Oncology
webers@surgery.wisc.edu
(608) 262-2025
- Administrative Assistant: (608) 262-2025
600 Highland Avenue
Clinical Science Center
Madison, Wisconsin 53792-7375
Education
- MD, University of Wisconsin Medical School, Madison, WI
- Residency in General Surgery, University of Wisconsin Hospital and Clinics, Madison, WI
- Research Fellowship in Tumor Immunotherapy, University of Wisconsin Medical School, Madison, WI
- Surgical Oncology Fellowship, Memorial Sloan-Kettering Cancer Center, New York, NY
- Hepatobiliary Fellowship, Memorial Sloan-Kettering Cancer Center, New York, NY
Clinical Specialties
Dr. Weber is actively involved in minimally invasive approaches to cancer treatment, including both laparoscopic pancreas and liver surgery. She has been invited as a speaker/moderator at many national meetings, including the American College of Surgeons, the American Hepatopancreaticobiliary Association, Society of Surgical Oncology, and Society of University Surgeons.
Dr. Weber provides a wide range of services including Bile Duct Resection, Caudate Resection, Cryoablation, Cyst Fenestration (Unroof Liver Cyst), Cytoreductive Surgery with HIPEC, Frey Procedure, Gastrectomy – Partial or Total, Hemihepatectomy (Hepatectomy), Laparoscopic Liver Resection, Liver Resection, Liver Tumor Ablations, Melanoma Completion Lymph Node Dissection (Axillary and Groin), Melanoma Sentinel Lymph Node Biopsy, Melanoma Wide Local Excision and Skin Closure, Obstructed Pancreatic Duct Drainage (Peustow Procedure), Pancreatic Head Resection, Pancreaticoduodenectomy, Pancreatic Pseudocysts Drainage, Pancreatic Resections, Radical Cholecystectomy, Radiofrequency Ablation, Right Hemihepatectomy, Right / Left Extended Hemihepatectomy (Hepatectomy), Wedge Resection of the Liver, Whipple Procedure.
Research Interests
Dr. Weber conducts translational research at the UW Carbone Cancer Center evaluating novel tumor selective agents which may be promising for imaging and/or treating tumors. She also conducts clinical research evaluating prognosticators of outcome in patients with liver, bile duct, and liver tumors. Dr. Weber’s research interests also include mixed methods evaluation of risk factors for readmission using a systems engineering approach with a focus on the transition of care and outcomes research evaluating preoperative predictors of postoperative complications.
Recent Publications
Assessing the Evidence for Neoadjuvant Chemotherapy in Patients with Resectable Pancreatic Adenocarcinoma Using the Robustness of Inference to Replacement.
Cher BAY, Lin Q, Frank KA, Weber SM, Minter RM, Balentine CJ, Zafar SN
Ann Surg Oncol 2026 Mar 12;
[PubMed ID: 41817933]Characterizing Social Determinants of Health in GI Cancer Surgery: Insights From the All of Us Research Program.
Al Rubaye MZ, Ahmed KS, Issaka SM, Ali MM, Cher BA, Awan AH, Owusu-Brackett N, Weber SM, Zafar SN
Cancer Rep (Hoboken) 2026 Mar; 9(3): e70518
[PubMed ID: 41856922]Tumor matrix proteoglycan accumulation and processing alters T cell effector function and the response to immunotherapy in patients with oligometastatic colorectal cancer.
Deming DA, Kraus SG, Brand J, Johnson KA, Abbott D, Kratz J, Turk AA, Emmerich P, Carchman E, Lubner SJ, LoConte NK, Uboha NV, Chaudhuri S, Shah R, Field A, Field E, Pasch CA, Kim DH, Weber S, Heise C, Lawson E, Sanger C, Matkowskyj K, Asimakopoulos F, Eickhoff J, Dinh HQ, Bassetti MF
Clin Cancer Res 2026 Feb 11;
[PubMed ID: 41671077]Novel Electronic Health Record-Based Data Commons for Pancreatic Cancer.
Ahmed KS, Marcinak CT, Ali MM, Issaka SM, Yan Y, McMahan G, Callaci T, LoConte NK, Shiefelbein A, Weber S, Afshar M, Churpek MM, Mathew J, Zafar SN
JCO Clin Cancer Inform 2026 Jan; 10: e2400265
[PubMed ID: 41512230]ASO Visual Abstract: Perineural Invasion Worsens Long-Term Outcome of Pancreatic Neuroendocrine Tumors following Surgical Resection.
Xu H, Hou JJ, Xiang JX, Lopez-Aguiar AG, Poultsides G, Rocha F, Weber S, Fields R, Idrees K, Cho C, Maithel SK, Lv Y, Zhang XF, Pawlik TM
Ann Surg Oncol 2026 Feb; 33(2): 1655-1656
[PubMed ID: 41217677]