The major focus of Dr. Yamanouchi’s lab is to understand the pathogenesis of abdominal aortic aneurysm and restenosis after angioplasty including balloon angioplasty and stent placement, especially through the calcium regulation in the arteriosclerotic disease.
Arterial calcification, commonly associated with aging and atherosclerosis, has recently attracted significant attention in the research community. Arterial calcification displays features of the highly organized processes seen in bone formation. Bone homeostasis is a carefully controlled system relying upon a delicate balance between mineral deposition and resorption as mediated by osteoblasts and osteoclasts, respectively. The presence of osteoclast-like cells (OLCs), which are derived from the monocyte/macrophage lineage and share osteoclast features such as the ability to dissolve extracellular matrix, has been noted in calcified arteries. Calcification is seldom considered a major feature of abdominal aortic aneurysm (AAA) and thus has remained a poorly explored avenue of study. This grant is aimed to explore the role of osteoclastogenesis, the development of OLCs, in AAA.
They are also devoted to the development of novel materials for vascular bypass graft and gene delivery method to treat the patients who suffers peripheral arterial disease.
Additional Research Interests
- Ultrasound image analysis of arterial stiffness – software to diagnose and monitor cardiovascular disease in collabolation with Echometrix
- Drug Delivery – Development of Target Drug Delivery System
- Gene Therapy – Development of Gene Therapy for Peripheral Vascular Disease