The following are selected humanized mouse publications from the Brown lab, highlighting the NeoThy model, as well as other commonly used models available through the Core.
Publications
Brown ME, Zhou Y, McIntosh BE, Norman IG, Lou HE, Biermann M, Sullivan JA, Kamp TJ, Thomson JA, Anagnostopoulos PV, Burlingham WJ. A Humanized Mouse Model Generated Using Surplus Neonatal Tissue. Stem Cell Reports 2018 Apr 10;10(4):1175-1183.
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Del Rio NM, Huang L, Murphy L, Babu JS, Daffada CM, Haynes WJ, Keck JG, Brehm MA, Shultz LD, Brown ME. Generation of the NeoThy Mouse Model for Human Immune System Studies. Lab Animal 2023 June Vol52, 149–168.
Del Rio NM, Huang L, Holm AM, Blashka W, Smith NA, Saha S, Bell AJ, Richardson J, Badior KE, Kastrup CJ, Brown ME. Neonatal and Pediatric Thymic Grafts Generate Similar Human T-cell Chimerism in Humanized Mice. Front Immunol (Sec Alloimmunity and Transplantation) 2026 July Vol 17.
Ling C, Li Q, Brown ME, Kishimoto Y, Toya Y, Devine EE, Choi KO, Nishimoto K, Norman IG, Tsegyal T, Jiang JJ, Burlingham WJ, Gunasekaran S, Smith LM, Frey BL, Welham NV. Bioengineered vocal fold mucosa for voice restoration. Sci Transl Med 2015 Nov 18;7(314):314ra187.
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McIntosh BE, Brown ME. No irradiation required: The future of humanized immune system modeling in murine hosts. Chimerism 2015 Apr 3;6(1-2):40-5.
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McIntosh BE, Brown ME, Duffin BM, Maufort JP, Vereide DT, Slukvin II, Thomson JA. Nonirradiated NOD,B6.SCID Il2rγ-/- Kit(W41/W41) (NBSGW) mice support multilineage engraftment of human hematopoietic cells. Stem Cell Reports 2015 Feb 10; 4(2):171-80.
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Funding
The Humanized Mouse Core is funded by fees for service. Additionally, the Core is generously supported by the University of Wisconsin Department of Surgery, the School of Medicine and Public Health, University of Wisconsin Department of Medicine [hyperlink to http://www.medicine.wisc.edu/ ], and the UW Stem Cell and Regenerative Medicine Center.
The content of this website is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.