Specialties
Education
- MD, University of Illinois at Urbana-Champaign, Champaign, IL
- PhD, University of Illinois at Urbana-Champaign, Champaign, IL
- Residency, The Johns Hopkins School of Medicine, Baltimore, MD
- Cardiothoracic Surgery Fellowship, Washington University in St. Louis, St. Louis, MO
Clinical Specialties
Dr. Harris is a thoracic surgeon specializing in lung transplant and general thoracic surgery. He has expertise in minimally invasive approaches including robotic techniques for benign and malignant disease of the chest and esophagus.
Dr. Harris provides a wide range of services including Lung Transplant, Bronchoscopy, Esophagectomy, Thoracoscopic Lobectomy, Segmentectomy, Thymectomy, Chest Wall Tumor Resection, Chest Wall and Thoracic Reconstruction, Tracheal Resection, Thoracoscopic Talc Pleurodesis, Pleurectomy and Decortication, Laparoscopic and Robotic Paraesophageal Hernia Repair.
Research Interests
Dr. Harris is interested in the development of new therapies for the management of immune suppression in lung transplant patients. He has particular interest in studying mechanisms of immune rejection and the use of adoptive therapies to provide long term suppression.
Recent Publications
An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes.
Singh NK, Alonso JA, Harris DT, Anderson SD, Ma J, Hellman LM, Rosenberg AM, Kolawole EM, Evavold BD, Kranz DM, Baker BM
Biochemistry 2020 Nov 03; 59(43): 4163-4175
[PubMed ID: 33074657]T-cell Receptors Engineered De Novo for Peptide Specificity Can Mediate Optimal T-cell Activity without Self Cross-Reactivity.
Sharma P, Harris DT, Stone JD, Kranz DM
Cancer Immunol Res 2019 Dec; 7(12): 2025-2035
[PubMed ID: 31548259]Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains.
Harris DT, Hager MV, Smith SN, Cai Q, Stone JD, Kruger P, Lever M, Dushek O, Schmitt TM, Greenberg PD, Kranz DM
J Immunol 2018 Feb 01; 200(3): 1088-1100
[PubMed ID: 29288199]Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex.
Harris DT, Wang N, Riley TP, Anderson SD, Singh NK, Procko E, Baker BM, Kranz DM
J Biol Chem 2016 Nov 18; 291(47): 24566-24578
[PubMed ID: 27681597]An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.
Harris DT, Singh NK, Cai Q, Smith SN, Vander Kooi C, Procko E, Kranz DM, Baker BM
Structure 2016 Jul 06; 24(7): 1142-1154
[PubMed ID: 27238970]