University of Wisconsin–Madison

David P. Al-Adra, MD, PhD

Assistant Professor

  • Division of Transplantation 

aladra@surgery.wisc.edu
(608) 265-6471

600 Highland Avenue
Madison WI 53792-7375

Education

  • MD, University of Alberta, 2007
  • PhD, Clinical Investigator Program in the Department of Surgery, University of Alberta, 2012
  • Residency, General Surgery, University of Alberta, 2015
  • Abdominal Organ Transplant Fellowship, University of Toronto, 2017

Clinical Specialties

Dr. Al-Adra is certified by the American Board of Surgery (ABS), the American Society of Transplant Surgeons (ASTS), the Royal College of Surgeons of Canada, and the Americas Hepato-Pancreato-Biliary Association (AHPBA). He specializes in liver, kidney, pancreas and pediatric transplantation, live donor liver transplantation (LDLT), and hepatobiliary surgery.

Research Interests

Dr. Al-Adra aims to investigate the mechanisms of immunological tolerance and attempt to induce tolerance to transplanted organs through organ pre-treatment and recipient preconditioning. The overall goal is to decrease immunity and promote tolerance towards solid organ transplants in order to decrease the need for immunosuppressive therapy. Specifically, this would involve investigating the cell surface expression of co-inhibitory and co-stimulatory structures of hepatocytes using flow cytometry. Modification of the expression of these surface molecules will then be done to promote co-inhibition and enhance immunological regulation. Ex-vivo perfusion technologies will allow investigation of different reagents and delivery systems used for whole organ modification. Further investigation would include evaluating the effect on the vascular microenvironment and local immune infiltration using cellular imaging.

Recent Publications

    • Live donor liver transplantation with older donors: Increased long-term graft loss due to HCV recurrence.
    • Goldaracena N, Barbas AS, Galante A, Sapisochin G, Al-Adra D, Selzner N, Galvin Z, Cattral MS, Greig PD, Lilly L, Bhat M, McGilvray ID, Ghanekar A, Levy G, Grant DR, Selzner M
    • Clin Transplant 2018 Aug; 32(8): e13304
    • [PubMed ID: 29947154]
    • Liver Transplantation Without Venovenous Bypass: Does Surgical Approach Matter?
    • Barbas AS, Levy J, Mulvihill MS, Goldaracena N, Dib MJ, Al-Adra DP, Cattral MS, Ghanekar A, Greig PD, Grant DR, Sapisochin G, Selzner M, McCluskey SA, McGilvray ID
    • Transplant Direct 2018 May; 4(5): e348
    • [PubMed ID: 29796419]
    • Liver Transplantation is Equally Effective as a Salvage Therapy for Patients with Hepatocellular Carcinoma Recurrence Following Radiofrequency Ablation or Liver Resection with Curative Intent.
    • Muaddi H, Al-Adra DP, Beecroft R, Ghanekar A, Moulton CA, Doyle A, Selzner M, Wei A, McGilvray ID, Gallinger S, Grant DR, Cattral MS, Greig PD, Kachura J, Cleary SP, Sapisochin G
    • Ann. Surg. Oncol. 2018 Apr; 25(4): 991-999
    • [PubMed ID: 29327179]
    • Pancreas Transplantation With Portal-Enteric Drainage for Patients With Endocrine and Exocrine Insufficiency From Extensive Pancreatic Resection.
    • Barbas AS, Al-Adra DP, Goldaracena N, Dib MJ, Selzner M, Sapisochin G, Cattral MS, McGilvray ID
    • Transplant Direct 2017 Sep; 3(9): e203
    • [PubMed ID: 28894791]
    • Preserving the Pancreas Graft: Outcomes of Surgical Repair of Duodenal Leaks in Enterically Drained Pancreas Allografts.
    • Al-Adra D, McGilvray I, Goldaracena N, Spetzler V, Laurence J, Norgate A, Marquez M, Greig P, Sapisochin G, Schiff J, Singh S, Selzner M, Cattral M
    • Transplant Direct 2017 Jul; 3(7): e179
    • [PubMed ID: 28706982]

All Publications on PubMed