Tanja Dominko, DVM, PhD
Professor
- Faculty Director, Center for Biomedical Swine Research and Innovation
- Division of Transplantation
dominko@wisc.edu
(608) 265-6437
5151 Wisconsin Institutes for Medical Research
1111 Highland Avenue
Madison, WI 53705
Education
- Postdoctoral fellow, Oregon National Primate Research Center
- PhD, Endocrinology-Reproductive Physiology, University of Wisconsin-Madison, Madison, WI
- MS, Reproduction and Obstetrics, University of Ljubljana School of Veterinary Medicine, Ljubljana, Slovenia
- DVM, Veterinary Medicine, University of Ljubljana School of Veterinary Medicine, Ljubljana, Slovenia
Research Interests
The Dominko Lab focuses on the effects of tissue environment on fibroblast behaviors during wound healing. We are interested in the molecular mechanisms responsible for oxygen and growth factor signaling during switching between pro-fibrotic and pro-regenerative cell phenotype, the role of extracellular matrix in cell fate determination, and cell-cell and cell-material interactions in three-dimensional tissue constructs. Our goals are to better understand the pathways leading to functional tissue regeneration, develop clinically relevant therapies for regenerative medicine, and accelerate translation of promising discoveries into large animal models.
Recent Publications
Differential Anti-Fibrotic and Remodeling Responses of Human Dermal Fibroblasts to Artemisia sp., Artemisinin, and Its Derivatives.
Weathers P, Towler M, Kiani BH, Dolivo D, Dominko T
Molecules 2024 May 02; 29(9)
[PubMed ID: 38731597]Decellularization: Leveraging a Tissue Engineering Technique for Food Production.
Jones JD, Thyden R, Perreault LR, Varieur BM, Patmanidis AA, Daley L, Gaudette GR, Dominko T
ACS Biomater Sci Eng 2023 May 08; 9(5): 2292-2300
[PubMed ID: 37126371]Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics.
Dolivo D, Weathers P, Dominko T
Acta Pharm Sin B 2021 Feb; 11(2): 322-339
[PubMed ID: 33643815]Artesunate inhibits myofibroblast formation via induction of apoptosis and antagonism of pro-fibrotic gene expression in human dermal fibroblasts.
Larson SA, Dolivo DM, Dominko T
Cell Biol Int 2019 Nov; 43(11): 1317-1322
[PubMed ID: 31441159]Crosstalk between mitogen-activated protein kinase inhibitors and transforming growth factor-β signaling results in variable activation of human dermal fibroblasts.
Dolivo DM, Larson SA, Dominko T
Int J Mol Med 2019 Jan; 43(1): 325-335
[PubMed ID: 30365043]