Specialties
Sean Ronnekleiv-Kelly, MD, FACS
Associate Professor
- Endowed Professor, Ronald E. and Patricia A. Kissinger Surgical Oncology Research Professorship
- Division of Surgical Oncology
ronnekleiv-kelly@surgery.wisc.edu
- Administrative Assistant: (608) 262-2025
600 Highland Avenue
Clinical Science Center
Madison WI 53792-7375
Education
- MD, University of Colorado School of Medicine
- General Surgery Residency, University of Wisconsin School of Medicine and Public Health
- Complex General Surgical Oncology Fellowship, Johns Hopkins Hospital
Clinical Specialties
Certified by the American Board of Surgery in General Surgery and specializes in malignant disease of the pancreas, liver, gallbladder and biliary tree, stomach and small intestine, neuroendocrine tumors and retroperitoneal sarcoma.
Research Interests
Principal research interest is pancreatic cancer. My lab focuses on formation and progression of pancreatic cancer as well as understanding communication within the tumor microenvironment.
Dr. Sean Ronnekleiv-Kelly was awarded a two-year, $276,000 grant from the Fibrolamellar Cancer Foundation. Read more here.
Dr. Ronnekleiv-Kelly received a two-year, $528,000 grant from the Fibrolamellar Cancer Foundation. Read more here.
Recent Publications
Single-Cell RNA Sequencing of Murine Liver Reveals an Aligned Circadian Clock and Cell-Population-Specific Circadian-Regulated Pathways.
Veltri AJ, Nukaya M, Korac K, Schwartz PB, Ronnekleiv-Kelly SM
J Biol Rhythms 2026 Jul 03; 7487304261453628
[PubMed ID: 42397025]Identifying Novel Estrogenic Mitochondrial Targets in Hypothalamic Proopiomelanocortin Neurons by Chemoproteomics.
Qiu J, Bosch MA, Wolfe M, Korac K, Rizzo S, Stincic TL, Farley SE, Fitzgerald W, Rajendran M, Laguerre A, Stein F, Copenhaver PF, Rønnekleiv OK, Rønnekleiv-Kelly SM, Rostovtseva TK, Bezrukov SM, Schultz C, Kelly MJ
bioRxiv 2026 Jun 22;
[PubMed ID: 42395377]The DNAJB1-PRKACA Oncogenic Fusion Drives Stepwise Biliary and Pancreatic Carcinogenesis from Intraductal Precursor Lesions.
Carney PR, Nukaya M, Carter JA, Veltri AJ, Matkowskyj KA, Stram A, Rubinstein CD, Veith AC, Pillarisetty VG, Bradfield CA, Ronnekleiv-Kelly SM
bioRxiv 2026 May 27;
[PubMed ID: 42244708]Single-cell Transcriptomic Variance Analysis Reveals Intercellular Circadian Desynchrony in the Alzheimer's Affected Human Brain.
Hollis HC, Veltri A, Korac K, Menon V, Bennett DA, Ronnekleiv-Kelly SM, Kim J, Anafi RC
bioRxiv 2026 Mar 25;
[PubMed ID: 41929229]Correction: DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma.
Ma RK, Tsai PY, Farghli AR, Shumway A, Kanke M, Gordan JD, Gujral TS, Vakili K, Nukaya M, Noetzli L, Ronnekleiv-Kelly S, Broom W, Barrow J, Sethupathy P
PLoS Genet 2026 Feb; 22(2): e1012054
[PubMed ID: 41746900]