Sean Ronnekleiv-Kelly, MD, FACS

Assistant Professor

  • Endowed Professor, Ronald E. and Patricia A. Kissinger Surgical Oncology Research Professorship 
  • Division of Surgical Oncology

  • Administrative Assistant: (608) 262-2025

600 Highland Avenue
Clinical Science Center
Madison WI 53792-7375


  • MD, University of Colorado School of Medicine, 2008
  • General Surgery Residency, University of Wisconsin School of Medicine and Public Health, 2015
  • Complex General Surgical Oncology Fellowship, Johns Hopkins Hospital, 2017

Clinical Specialties

Certified by the American Board of Surgery in General Surgery and specializes in malignant disease of the pancreas, liver, gallbladder and biliary tree, stomach and small intestine, neuroendocrine tumors and retroperitoneal sarcoma.

Research Interests

Principal research interest is pancreatic cancer. My lab focuses on formation and progression of pancreatic cancer as well as understanding communication within the tumor microenvironment.

Dr. Ronnekleiv-Kelly’s Lab >>

Recent Publications

  • NCCN Guidelines® Insights: Biliary Tract Cancers, Version 2.2023.
    Benson AB, D'Angelica MI, Abrams T, Abbott DE, Ahmed A, Anaya DA, Anders R, Are C, Bachini M, Binder D, Borad M, Bowlus C, Brown D, Burgoyne A, Castellanos J, Chahal P, Cloyd J, Covey AM, Glazer ES, Hawkins WG, Iyer R, Jacob R, Jennings L, Kelley RK, Kim R, Levine M, Palta M, Park JO, Raman S, Reddy S, Ronnekleiv-Kelly S, Sahai V, Singh G, Stein S, Turk A, Vauthey JN, Venook AP, Yopp A, McMillian N, Schonfeld R, Hochstetler C
    J Natl Compr Canc Netw 2023 Jul; 21(7): 694-704
    [PubMed ID: 37433432]

  • The circadian clock is disrupted in pancreatic cancer.
    Schwartz PB, Nukaya M, Berres ME, Rubinstein CD, Wu G, Hogenesch JB, Bradfield CA, Ronnekleiv-Kelly SM
    PLoS Genet 2023 Jun; 19(6): e1010770
    [PubMed ID: 37262074]

  • Pdx1 expression in hematopoietic cells activates Kras-mutation to drive leukemia in KC (Pdx1-Cre; LSL-KrasG12D/+) mice.
    Walcheck MT, Nukaya M, Ranheim EA, Matkowskyj KA, Ronnekleiv-Kelly S
    Leuk Lymphoma 2023 Jun; 64(6): 1112-1122
    [PubMed ID: 37081806]

  • Chronic jetlag accelerates pancreatic neoplasia in conditional Kras-mutant mice.
    Schwartz PB, Walcheck MT, Nukaya M, Pavelec DM, Matkowskyj KA, Ronnekleiv-Kelly SM
    Chronobiol Int 2023 Apr; 40(4): 417-437
    [PubMed ID: 36912021]

  • Aryl hydrocarbon receptor knockout accelerates PanIN formation and fibro-inflammation in a mutant Kras -driven pancreatic cancer model.
    Walcheck MT, Schwartz PB, Carrillo ND, Matkowsky KA, Nukaya M, Bradfield CA, Ronnekleiv-Kelly SM
    bioRxiv 2023 Feb 03;
    [PubMed ID: 36778364]

All Publications on PubMed