To understand how the Per-Arnt-Sim family of ‘environmental sensor’ proteins impacts aggressive cancers including pancreatic cancer and Fibrolamellar carcinoma; and to exploit this class of proteins for therapeutic effect.
- Understanding how circadian biology plays a role in pancreas cancer and how circadian rhythm disruption contributes to pancreatic cancer development and spread.
- Evaluating the extent to which the aryl hydrocarbon receptor impacts immune cell infiltration in the pancreatic cancer microenvironment and shapes the developing tumor.
- Building unique models for understanding Fibrolamellar carcinoma development and identifying efficacious therapies.
Contact Dr. Ronnekleiv-Kelly
Sean Ronnekleiv-Kelly, MD, FACS
Madison, WI 53792