Scientist
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Manabu Nukaya, PhD
Manabu Nukaya, PhD
Scientist
(June 2019 – Present)
Associate scientist in the laboratory with extensive experience in liver pathology, liver metabolism, cloning, and gene-editing techniques for novel model development. Manabu has worked to generate unique models for understanding Fibrolamellar carcinoma including cell lines to investigate pathway analysis and to identify new therapeutic combinations through small molecule screening and CRISPR screens. Manabu has also developed novel in vivo models for understanding development of FLC.
Post-Doctoral Fellows
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Patrick Carney, MD, PhD
Patrick Carney, MD, PhD
Graduate Student
(June 2021 – Present)
Graduate student / medical student who is interested in identifying sequencing methods to characterize Fibrolamellar carcinoma. This includes adaptive sequencing and CRISPR sequencing to identify structural variants such as fusion / re-arrangement events, whole genome sequencing to identify concomitant mutations. Patrick is also defining FLC pre-cursor lesions in a mouse model of FLC using immunohistochemistry and in-situ hybridization.
Awards:
- ICTR-MSTP Pilot Award – Development of a Novel Sequencing Protocol for Detection of and Mechanistic Insight into Fibrolamellar Carcinoma (July 2019)
- UWCCC Pilot Grant – Elucidation of the Role of the Aryl Hydrocarbon Receptor in Colorectal Tumorigenesis and Development of Novel Chemoprevention Strategies (Bradfield co-PI)
- UWCCC GI Disease Oriented Team Trainee Grant – While Genome and CRISPR Sequencing of Fibrolamellar Carcinoma (July 2021)
Ksenija Korac, PhD
Graduate Students
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Austin Stram
Undergraduate Students
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Matthew Shen
Matthew Shen
Undergraduate Student
Matthew Shen is an undergraduate at the University of Wisconsin-Madison who is interested in cancer biology. He is studying the role of the circadian clock in pancreatic cancer, with a focus on the role of BMAL1 in pancreas cancer growth and spread.
Awards: The University of Wisconsin Sophomore Research Fellowship Award 2023