Research
The Division of Transplantation has earned acclaim from the international medical community for such breakthroughs as the UW-Belzer solution for organ preservation, research and clinical trials into the immunosuppressive drug mycophenolate mofetil, and improved surgical technqiues for pancreas transplantation.
Current laboratory research includes programs in organ preservation, the development of new immuosuppressants, gene therapy for diabetes as an alternative to pancreas transplantation, and induction of immunological tolerance to organ transplantation as an alternative to lifelong immunosuppression.
Active Clinical Trials
The Transplant Clinical Trials Office can be contacted at 608-263-2565.
Kidney |
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A Partially Blinded, Prospective, Randomized Multicenter Study Evaluating Efficacy, Safety and Tolerability of Oral Sotrastaurin Plus Standard or Reduced Exposure Tacrolimus vs. Mycophenolic Acid Plus Tacrolimus in de Novo Renal Transplant Recipients Principal Investigator(s): Hans W. Sollinger, MD, PhD, FACS Status: Active, not recruiting [ClinicalTrials.gov: NCT01064791] More Information |
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Controlled, Randomized, Prospective, Double-Blind, Multicenter, Phase I/II, Dose-Escalation Study of the Safety, PK, and Clinical Activity of I5NP for Prophylaxis of Delayed Graft Function in Patients Undergoing Deceased Donor Kidney Transplantation Principal Investigator(s): David P Foley, MD Status: Recruiting [ClinicalTrials.gov: NCT00802347] More Information |
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Effect of Fluoroquinolones on BK Viremia in the Renal Transplant Recipient, A Multi-Center Study Status: Recruiting [ClinicalTrials.gov: NCT01034176] More Information |
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Genomics of Chronic Renal Allograft Rejection Status: Active, not recruiting [ClinicalTrials.gov: NCT00611702] More Information |
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Mycophenolic Acid Monotherapy in Recipients of HLA-identical Living-Related Transplantation Principal Investigator(s): William J Burlingham, PhD, Hans W. Sollinger, MD, PhD, FACS Status: Recruiting [ClinicalTrials.gov: NCT01053221] More Information |
Liver |
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A 24-month Randomized Multicenter Study Evaluating Efficacy, Safety, Tolerability and Pharmacokinetics of Sotrastaurin and Tacrolimus vs. a Tacrolimus/Mycophenolate Mofetil-based Control Regimen in de Novo Liver Transplant Recipients Principal Investigator(s): Anthony M D’Alessandro, MD Status: Recruiting [ClinicalTrials.gov: NCT01128335] More Information |
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DSR-guided Tacrolimus Withdrawal to Myfortic Monotherapy in Liver Transplantation Principal Investigator(s): William J Burlingham, PhD Status: Recruiting [ClinicalTrials.gov: NCT01230502] More Information |
Pancreas / Islet |
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Calcineurin Inhibitor-free, Steroid-free Immunosuppressive Regimen in Simultaneous Islet-Kidney Transplantation for Uremic Type 1 Diabetic Patients Principal Investigator(s): Luis A Fernandez, MD Status: Recruiting [ClinicalTrials.gov: NCT01033500] More Information |
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Islet Transplantation in Type 1 Diabetic Patients Using a Steroid-free Immunosuppression Protocol and Thiazolidinedione Insulin Sensitizers Principal Investigator(s): Jon S Odorico, MD Status: Recruiting [ClinicalTrials.gov: NCT00214253] More Information |
Research Labs
Active Funding/Grants
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Mechanisms behind Thymic Involution and Immunosuppression after exposure to Dioxin
Funding Agency: Institute for Clinical and Translational Research
Principal Investigator(s): Joshua D Mezrich, MD
More Information -
TH17 Autoimmunity to Type V Collagen in Heart and Lung Transplant
Funding Agency: National Institutes of Health/Indiana University
Principal Investigator(s): William J Burlingham, PhD
More Information