Research
Research in the Division of General Surgery has grown tremendously over the past several years. Our portfolio of research grants has become even more diversified with the addition of several new productive faculty members with laboratory research programs. Our clinical and basic science research programs are investigating causes and treatments for various cancers including colorectal, endocrine, hepatic, and thyroid. In addition, novel treatments and nutrition for trauma patients, intimal hyperplasia, and pulmonary edema represent other current research initiatives.
The Division of General Surgery is also home to two NIH-funded institutional training grants, offering research training opportunities for post-doctoral fellows in the field of surgical oncology, as well as short-term summer research opportunities for medical students in programs related to diabetes, digestive diseases, and kidney diseases.
Research Labs
Active Funding/Grants
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AAS Courses to Increase Women and Minorities in Academic Surgery
Funding Agency: National Institutes of Health (NIH)
Principal Investigator(s): Herbert Chen, MD
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Co-delivery of siRNA and Anticancer Drug Using Multifunctional Au NR-based Nanocarriers for Targeted Neuroendocrine Cancer Therapy
Funding Agency: UWCCC/Wisconsin Discovery Institute
Principal Investigator(s): Herbert Chen, MD
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Genetic Insight into AH Receptor-Mediated Promotion of Hepatocarcinogeneses
Funding Agency: National Institutes of Health
Principal Investigator(s): Gregory D Kennedy, MD, PhD
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GSK3β Signaling in Medullary Thyroid Cancer
Funding Agency: National Institutes of Health
Principal Investigator(s): Herbert Chen, MD
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Identification and Characterization of Gastrointestinal Mucosal Immune Defects in Hirschsprung’s Disease
Funding Agency: Central Surgical Association
Principal Investigator(s): Ankush Gosain, MD, PhD
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Medullary Thyroid Carcinoma Surveillance Study: a Case Series Registry
Funding Agency: Novo Nordisk
Principal Investigator(s): Herbert Chen, MD
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MEN2 Thyroid Cancer Professorship
Funding Agency: American Cancer Society
Principal Investigator(s): Herbert Chen, MD
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Modulating Raf-1 Signaling in Carcinoid Cancer
Funding Agency: Carcinoid Cancer Foundation
Principal Investigator(s): Herbert Chen, MD
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Notch Signaling in Medullary Thyroid Cancer
Funding Agency: American Cancer Society
Principal Investigator(s): Herbert Chen, MD
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Novel Nanomedicines for Targeted Neuroendocrine Cancer Therapy
Funding Agency: UW Madison/Milwaukee
Principal Investigator(s): Herbert Chen, MD
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Route of Nutrition and Enteric Nervous System Effects on Innate Mucosal Defenses
Funding Agency: VA Office of Research and Development
Principal Investigator(s): Kenneth Allan Kudsk, MD
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Surgery Clinical Research Experiences for High School Students
Funding Agency: Doris Duke Charitable Foundation
Principal Investigator(s): Herbert Chen, MD
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Surgery Summer Experience for Medical Students
Funding Agency: NIH/NIDDK
Principal Investigator(s): Herbert Chen, MD
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Surgical Oncology Research Training Program
Funding Agency: NIH/NCI
Principal Investigator(s): Herbert Chen, MD
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T Cell Homeostasis and Melanoma
Funding Agency: Department of Veterans Affairs – Career Development Award (CDA-2)
Principal Investigator(s): Clifford S Cho, MD
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The Role of GSK3β in Carcinoid and Other Neuroendocrine Cancers
Funding Agency: The Doctors Cancer Foundation
Principal Investigator(s): Herbert Chen, MD
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Active Clinical Trials
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A Phase II Study of Preoperative Gemcitabine and Erlotinib Plus Pancreatectomy and Postoperative Gemcitabine and Erlotinib for Patients With Operable Pancreatic Adenocarcinoma
Principal Investigator(s):Sharon M Weber, MD
Status: Recruiting
[ClinicalTrials.gov: NCT00733746]
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A Phase III Multicenter Randomized Trial of Sentinel Lymphadenectomy and Complete Lymph Node Dissection Versus Sentinel Lymphadenectomy Alone in Cutaneous Melanoma Patients With Molecular or Histopathological Evidence of Metastases in the Sentinel Node
Principal Investigator(s): Heather B Neuman, MD, MS
Status: Recruiting
[ClinicalTrials.gov: NCT00297895]
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A Phase III Study of Chemotherapy and Chemoradiotherapy With or Without HyperAcute®-Pancreas (Algenpantucel-L) Immunotherapy in Subjects With Surgically Resected Pancreatic Cancer
Principal Investigator(s): Clifford S Cho, MD
Status: Recruiting
[ClinicalTrials.gov: NCT01072981]
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A Prognostic Study of Sentinel Node and Bone Marrow Micrometastases in Women With Clinical T1-2 N0 Breast Cancer
Principal Investigator(s): Sharon M Weber, MD
Status: Active, not recruiting
[ClinicalTrials.gov: NCT00003854]
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A Randomized Trial of Axillary Node Dissection in Women With Clinical T1-2 N0-1 M0 Breast Cancer Who Have a Positive Sentinel Node
Principal Investigator(s): Sharon M Weber, MD
Status: Active, not recruiting
[ClinicalTrials.gov: NCT00003855]
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A Randomized, Open Label, Parallel-group, Multi-center Trial to Compare the Efficacy and Safety of TachoSil® Versus Surgicel® Original for the Secondary Treatment of Local Bleeding in Adult and Pediatric Patients Undergoing Hepatic Resection Surgery
Principal Investigator(s): Sharon M Weber, MD
Status: Active, not recruiting
[ClinicalTrials.gov: NCT01192022]
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An Open-Label, Controlled, Randomized, Multicenter, Dose Escalation Study Evaluating the Safety and Efficacy of StrataGraft® Skin Tissue in Promoting the Healing of the Deep Partial-Thickness Component of Complex Skin Defects as an Alternative to Autografting
Principal Investigator(s): Lee D Faucher, MD
Status: Active, not recruiting
[ClinicalTrials.gov: NCT01437852]
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Phase III Study on the Efficacy of Glutamine Dipeptide-Supplemented Parenteral Nutrition in Surgical ICU Patients
Principal Investigator(s): Kenneth Allan Kudsk, MD
Status: Active, not recruiting
[ClinicalTrials.gov: NCT00248638]
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