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Authors Schneider DF, Palmer JL, Tulley JM, Speicher JT, Kovacs EJ, Gamelli RL, Faunce DE
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Journal J. Surg. Res. Volume: 168 Issue: 2 Pages: 325-33.e1
Publish Date 2011 Jun 15
PubMed ID 20089261
PMC ID 3324973
Abstract

Here, we report the novel observation that natural killer T (NKT) cells contribute to the cutaneous wound repair process. Using an excisional wound model in wild-type versus NKT cell-deficient mice, this report shows that when NKT cells are absent, initial wound closure is markedly accelerated. We report here for the first time that NKT cells are a significant constituent of early wound inflammation and that they regulate the local production of a key subset of neutrophil and monocyte/macrophage chemokines, as well as TGF-β1 content and collagen deposition. Together, our findings support the concept that NKT cells regulate the early inflammatory and fibroproliferative phases of nonpathologic healing wounds, positioning the NKT cell as an attractive potential therapeutic target for modulation of impaired wound healing.

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