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Authors Bodi I, Mikala G, Koch SE, Akhter SA, Schwartz A
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Journal J. Clin. Invest. Volume: 115 Issue: 12 Pages: 3306-17
Publish Date 2005 Dec
PubMed ID 16322774
PMC ID 1297268

Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.

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