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Authors Nichol PF, Reeder A, Botham R
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Journal J. Gastrointest. Surg. Volume: 15 Issue: 4 Pages: 694-700
Publish Date 2011 Apr
PubMed ID 21116726
PMC ID 3299083

Intestinal atresias have long been hypothesized to result from either failure of recanalization of the intestinal lumen or in utero vascular accidents. Recent work in animal models is now calling for a reassessment of these widely held paradigms.In this review, we will examine the data that led to the original hypotheses and then evaluate more recent work challenging these hypotheses. Furthermore, we will discuss how defining the mechanism of atresia formation in animal models may provide insight into early intestinal development and the mechanism of lengthwise intestinal growth.Such insight will be critical in developing regenerative therapies for patients with intestinal failure.

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