Skip to Content
Authors Pinchot SN, Sippel R, Chen H
Author Profile(s)
Journal World J Surg Oncol Volume: 7 Pages: 39
Publish Date 2009 Apr 08
PubMed ID 19356251
PMC ID 2678126

Pituitary carcinomas are rare neuroendocrine tumors affecting the adenohypophysis. The hallmark of these lesions is the demonstration of distant metastatic spread. To date, few well-documented cases have been reported in the literature.Here, we report the case of a fatal pituitary carcinoma evolving within two years from an adrenocorticotrophic hormone (ACTH)-secreting macroadenoma and review the global literature regarding this rare neuroendocrine tumor.Pituitary carcinomas are extremely rare neoplasms, representing only 0.1% to 0.2% of all pituitary tumors. To date, little is understood about the molecular basis of malignant transformation. The latency period between initial presentation of a pituitary adenoma and the development of distal metastases marking carcinoma is extremely variable, and some patients may live well over 10 years with pituitary carcinoma.

Full Text Full text available on PubMed Central Copyright © 2017 The Board of Regents of the University of Wisconsin System