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Authors Kunnimalaiyaan M, Haymart MR, Chen H
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Journal Transl Oncogenomics Volume: 2 Pages: 43-7
Publish Date 2007
PubMed ID 23641144
PMC ID 3634621
Abstract

There is a growing body of literature suggesting that signaling based therapy might be a potential approach for medullary thyroid cancer (MTC). In this review we focus on the tumor suppressor role of Notch1 and Raf-1 signaling in MTC. Interestingly these two pathways are minimally active or absent in these tumors and activation of Notch1 and Raf-1 significantly reduces tumor growth in vitro. Therefore, identification of compounds that induce these pathways could be a potential strategy to treat patients with MTC.

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