|Authors||Kunnimalaiyaan M, Haymart MR, Chen H|
|Journal||Transl Oncogenomics Volume: 2 Pages: 43-7|
There is a growing body of literature suggesting that signaling based therapy might be a potential approach for medullary thyroid cancer (MTC). In this review we focus on the tumor suppressor role of Notch1 and Raf-1 signaling in MTC. Interestingly these two pathways are minimally active or absent in these tumors and activation of Notch1 and Raf-1 significantly reduces tumor growth in vitro. Therefore, identification of compounds that induce these pathways could be a potential strategy to treat patients with MTC.
|Full Text||Full text available on PubMed Central|