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Authors Parsons RF, Redfield RR, Rodriguez E, Mustafa MM, Vivek K, Murayama M, Naji A, Noorchashm H
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Journal Semin. Immunol. Volume: 24 Issue: 2 Pages: 109-14
Publish Date 2012 Apr
PubMed ID 21978627

The current mainstay of immunotherapy in clinical transplantation is T lymphocyte directed. However, it has long been appreciated that the emergence of an alloimmune response mounted by the B lymphocyte compartment and detectable as donor-specific antibodies is a critical challenge to long-term graft survival. Thus, achieving robust transplantation tolerance will require induction of tolerance in both the T- and B-cell compartments. Here we propose that the natural developmental propensity of the B-lymphocyte compartment acquisition of tolerance to self-antigens can be recapitulated to achieve humoral transplantation tolerance. It is our contention B-lymphocyte directed induction immunotherapy would be an important component of emerging strategies for induction of Transplantation tolerance. Copyright © 2016 The Board of Regents of the University of Wisconsin System