|Authors||Vivek K, Mustafa MM, Rodriguez E, Redfield RR, Parsons RF, Rostami S, Migone TS, Cancro MP, Naji A, Noorchashm H|
|Journal||Immunol. Res. Volume: 51 Issue: 1 Pages: 1-4|
|Publish Date||2011 Oct|
Transplantation tolerance remains an elusive goal as B-cell-initiated chronic humoral rejection evades current immunosuppression. B-cell-directed therapy is thus emerging as a key component in achieving transplantation tolerance and long-term graft survival. Here, we propose strategies of B-cell repertoire remodeling to achieve humoral unresponsiveness to donor antigens with implementation of fundamental B-cell immunobiology and use of newly developed B-cell-directed agents.