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Authors Vivek K, Mustafa MM, Rodriguez E, Redfield RR, Parsons RF, Rostami S, Migone TS, Cancro MP, Naji A, Noorchashm H
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Journal Immunol. Res. Volume: 51 Issue: 1 Pages: 1-4
Publish Date 2011 Oct
PubMed ID 21948256

Transplantation tolerance remains an elusive goal as B-cell-initiated chronic humoral rejection evades current immunosuppression. B-cell-directed therapy is thus emerging as a key component in achieving transplantation tolerance and long-term graft survival. Here, we propose strategies of B-cell repertoire remodeling to achieve humoral unresponsiveness to donor antigens with implementation of fundamental B-cell immunobiology and use of newly developed B-cell-directed agents. Copyright © 2016 The Board of Regents of the University of Wisconsin System