|Authors||Chen H, Kunnimalaiyaan M, Van Gompel JJ|
|Journal||Thyroid Volume: 15 Issue: 6 Pages: 511-21|
|Publish Date||2005 Jun|
Medullary thyroid cancer (MTC) is a prototypic neuroendocrine tumor of the thyroid C cells. Other than surgery, there are no curative therapies for MTC. In this review, we detail recent studies that suggest that targeting specific signaling pathways may be a viable strategy to control MTC tumor progression. Specifically, we discuss the role of the raf-1 and achaete-scute homologue-1 pathways in the MTC tumor growth and differentiation.