Skip to Content
Authors Neidlinger NA, Sollinger HW
Author Profile(s)
Journal Transplant. Proc. Volume: 42 Issue: 5 Pages: 1402-7
Publish Date 2010 Jun
PubMed ID 20620444

The use of an antibody induction agent in kidney transplantation lowers the risk of an acute rejection episode and may improve graft outcomes. Antithymocyte globulin (ATG) is the most commonly used antibody induction agent for kidney transplantation in the United States, despite its significant side effect profile and cost compared to the interleukin-2 receptor antagonists (IL2-RA). Our review suggests the IL2-RA are safe and well tolerated, and provide equal clinical benefit to ATG at a lower cost. We propose that there is insufficient evidence to justify the use of ATG induction in kidney transplantation. Copyright © 2017 The Board of Regents of the University of Wisconsin System